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MeSH Review:

Lymphoma, Small Noncleaved-Cell

Bernstein, J.I. et al., Jones, D. et al., Breen, E.C. et al., Carbone, A. et al., Brecher, M.L. et al., et al.

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Disease relevance of Lymphoma, Small Noncleaved-Cell

CXCR3 immunohistochemical or flow cytometric expression was seen in 37 of 39 cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (diffusely positive in 33 cases), whereas mantle cell lymphoma (30 cases), follicular lymphoma (27 cases), and small noncleaved cell lymphoma (8 cases) were negative in all but 2 cases [1].
Patients with lymphoblastic lymphoma or diffuse undifferentiated lymphoma did poorly with CBV and should be offered alternative therapy [2].
A total of 34 AIDS-NHL biopsies, including 16 AIDS-related diffuse large-cell lymphomas (AIDS-DLCLs) and 18 AIDS-related small-noncleaved-cell lymphomas (AIDS-SNCCLs) as well as 7 AIDS-SNCCL cell lines were immunostained with a BCL-6-specific monoclonal antibody [3].
Serum IL6 was significantly elevated in subjects who developed Burkitt's/small noncleaved cell lymphoma (BL/SNC, P = 0.01), but not in those subjects who developed large cell, immunoblastic, or central nervous system lymphomas, compared to CD4-matched AIDS controls who did not have lymphoma [4].

High impact information on Lymphoma, Small Noncleaved-Cell

Between June 1979 and June 1984 18 adult patients with small noncleaved cell lymphoma (SNCL) (diffuse undifferentiated lymphoma, Burkitt's and non-Burkitt's types of the Rappaport classification) were treated with high-dose cyclophosphamide, doxorubicin, vincristine, prednisone, midcycle high-dose methotrexate, and intrathecal methotrexate [5].
In these lesions, monotypic cytoplasmic immunoglobulin is not detected, and the CD44 and LFA-1 molecules usually are not expressed, particularly in small noncleaved cell lymphomas of the Burkitt type [6].
Thirty previously untreated adults with diffuse histiocytic and diffuse undifferentiated lymphoma were treated with a combination of adriamycin, vincristine, prednisolone, and L-asparaginase [7].
Fractionated cylophosphamide and back to back high dose methotrexate and cytosine arabinoside improves outcome in patients with stage III high grade small non-cleaved cell lymphomas (SNCCL): a randomized trial of the Pediatric Oncology Group [8].
New regimens incorporating high-dose cytarabine for patients with poor prognosis, small noncleaved-cell lymphoma seem to improve survival [9].

References

The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia. Jones, D., Benjamin, R.J., Shahsafaei, A., Dorfman, D.M. Blood (2000) [Pubmed]
Prognostic factors for treatment outcome in autotransplantation of intermediate-grade and high-grade non-Hodgkin's lymphoma with cyclophosphamide, carmustine, and etoposide. Wheeler, C., Strawderman, M., Ayash, L., Churchill, W.H., Bierer, B.E., Elias, A., Gilliland, D.G., Antman, K., Guinan, E.C., Eder, J.P. J. Clin. Oncol. (1993) [Pubmed]
BCL-6 protein expression in AIDS-related non-Hodgkin's lymphomas: inverse relationship with Epstein-Barr virus-encoded latent membrane protein-1 expression. Carbone, A., Gaidano, G., Gloghini, A., Pastore, C., Saglio, G., Tirelli, U., Dalla-Favera, R., Falini, B. Am. J. Pathol. (1997) [Pubmed]
The development of AIDS-associated Burkitt's/small noncleaved cell lymphoma is preceded by elevated serum levels of interleukin 6. Breen, E.C., van der Meijden, M., Cumberland, W., Kishimoto, T., Detels, R., Martínez-Maza, O. Clin. Immunol. (1999) [Pubmed]
Combined modality therapy for adults with small noncleaved cell lymphoma (Burkitt's and non-Burkitt's types). Bernstein, J.I., Coleman, C.N., Strickler, J.G., Dorfman, R.F., Rosenberg, S.A. J. Clin. Oncol. (1986) [Pubmed]
Diffuse aggressive B-cell lymphomas of the gastrointestinal tract. An immunophenotypic and gene rearrangement analysis of 22 cases. Van Krieken, J.H., Medeiros, L.J., Pals, S.T., Raffeld, M., Kluin, P.M. Am. J. Clin. Pathol. (1992) [Pubmed]
Combination chemotherapy for advanced non-Hodgkin's lymphoma of unfavourable histology. Lister, T.A., Cullen, M.H., Brearley, R.B., Beard, M.E., Stansfeld, A.G., Whitehouse, J.M., Wrigley, P.F., Ford, J.M., Malpas, J.S., Crowther, D. Cancer Chemother. Pharmacol. (1978) [Pubmed]
Fractionated cylophosphamide and back to back high dose methotrexate and cytosine arabinoside improves outcome in patients with stage III high grade small non-cleaved cell lymphomas (SNCCL): a randomized trial of the Pediatric Oncology Group. Brecher, M.L., Schwenn, M.R., Coppes, M.J., Bowman, W.P., Link, M.P., Berard, C.W., Shuster, J.J., Murphy, S.B. Med. Pediatr. Oncol. (1997) [Pubmed]
Treatment of aggressive histology lymphoma. Bartlett, N.L. Current opinion in oncology. (1997) [Pubmed]

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