The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 production is inhibited by taurine chloramine in rat C6 glioma cells.

Taurine monochloramine (Tau-Cl) is formed through the actions of a halide-dependent myeloperoxidase system associated with polymorphonuclear leukocytes (PMN). Tau-Cl inhibits production of inflammatory mediators by activated macrophages, and PMN. Recently, Tau-Cl was shown to inhibit production of nitric oxide and prostaglandin E2 by activated C6 glioma cells. Since chemokines, secreted by activated glial cells, play a prominent role in eliciting inflammatory responses in the central nervous system, the effects of Tau-Cl on production of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) were determined in activated C6 glioma cells. Tau-Cl inhibited production of MCP-1 and MIP-2 in a concentration-dependent manner, and was most potent against MCP-1. Tau-Cl exerted a transient inhibition of the temporal expression of MCP-1 and MIP-2 mRNAs during the first 4 h of activation. Although both chemokine mRNA levels were similar to those of control cells after 8-24 h of activation, production of the chemokine proteins, especially MCP-1, remained markedly low. These results suggest that Tau-Cl inhibits production of MCP-1 and MIP-2 in activated C6 cells primarily through post-transcriptional mechanisms.[1]


WikiGenes - Universities