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Gene Review

Ccl2  -  chemokine (C-C motif) ligand 2

Rattus norvegicus

Synonyms: C-C motif chemokine 2, Immediate-early serum-responsive protein JE, Je, MCP-1, Mcp1, ...
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Disease relevance of Ccl2


Psychiatry related information on Ccl2


High impact information on Ccl2


Chemical compound and disease context of Ccl2


Biological context of Ccl2


Anatomical context of Ccl2


Associations of Ccl2 with chemical compounds

  • Macrophage infiltration occurred in parallel with the expression of VCAM-1 and MCP-1, and these inflammatory cells were present on the luminal surface of injured vessels during intimal lesion formation [19].
  • However, simultaneous blockade of the ERK1/2 and ROS pathways by using PD098059 combined with diphenylene iodonium or N-acetylcysteine potently enhanced the ability of MAPK kinase inhibitors to abrogate MCP-1 mRNA expression (100+/-2% inhibition) [20].
  • CONCLUSION: These data suggest that glomerular macrophage recruitment in experimental diabetes is largely determined by angiotensin-stimulated MCP-1 expression [3].
  • Expression of vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1 adhesion molecules involved in SMCs migration was enhanced by AA, whereas EPA and DHA had no similar effects [21].
  • Pretreatment of VSMCs with p38 MAPK inhibitors, SB203580 and SB202190, resulted in a dose-dependent inhibition of chylomicron remnants-induced MCP-1 mRNA and protein expression, whereas a MAPK kinase inhibitor, PD98059, had no effect on these responses [22].

Physical interactions of Ccl2


Regulatory relationships of Ccl2


Other interactions of Ccl2


Analytical, diagnostic and therapeutic context of Ccl2


  1. Gene transfer of RANTES and MCP-1 chemokine antagonists prolongs cardiac allograft survival. Fleury, S., Li, J., Simeoni, E., Fiorini, E., von Segesser, L.K., Kappenberger, L., Vassalli, G. Gene Ther. (2006) [Pubmed]
  2. Monocyte chemoattractant protein-1 mediates monocyte/macrophage influx in anti-thymocyte antibody-induced glomerulonephritis. Wenzel, U., Schneider, A., Valente, A.J., Abboud, H.E., Thaiss, F., Helmchen, U.M., Stahl, R.A. Kidney Int. (1997) [Pubmed]
  3. Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats. Kato, S., Luyckx, V.A., Ots, M., Lee, K.W., Ziai, F., Troy, J.L., Brenner, B.M., MacKenzie, H.S. Kidney Int. (1999) [Pubmed]
  4. Dual regulation of tumor necrosis factor-alpha-induced CCL2/monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-kappaB and activator protein-1: modulation by type III phosphodiesterase inhibition. Chen, Y.M., Chiang, W.C., Lin, S.L., Wu, K.D., Tsai, T.J., Hsieh, B.S. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  5. Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha. Watanabe, T., Higuchi, K., Hamaguchi, M., Shiba, M., Tominaga, K., Fujiwara, Y., Matsumoto, T., Arakawa, T. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  6. Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain. Banisadr, G., Quéraud-Lesaux, F., Boutterin, M.C., Pélaprat, D., Zalc, B., Rostène, W., Haour, F., Parsadaniantz, S.M. J. Neurochem. (2002) [Pubmed]
  7. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. Villa, P., Bigini, P., Mennini, T., Agnello, D., Laragione, T., Cagnotto, A., Viviani, B., Marinovich, M., Cerami, A., Coleman, T.R., Brines, M., Ghezzi, P. J. Exp. Med. (2003) [Pubmed]
  8. C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis. Youssef, S., Maor, G., Wildbaum, G., Grabie, N., Gour-Lavie, A., Karin, N. J. Clin. Invest. (2000) [Pubmed]
  9. Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1. Johnston, B., Burns, A.R., Suematsu, M., Issekutz, T.B., Woodman, R.C., Kubes, P. J. Clin. Invest. (1999) [Pubmed]
  10. Regulatory roles of tumor necrosis factor-alpha and interleukin-1 beta in monocyte chemoattractant protein-1-mediated pulmonary granuloma formation in the rat. Flory, C.M., Jones, M.L., Miller, B.F., Warren, J.S. Am. J. Pathol. (1995) [Pubmed]
  11. Endogenous VEGF-A is responsible for mitogenic effects of MCP-1 on vascular smooth muscle cells. Parenti, A., Bellik, L., Brogelli, L., Filippi, S., Ledda, F. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  12. Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells. Chen, X.L., Tummala, P.E., Olbrych, M.T., Alexander, R.W., Medford, R.M. Circ. Res. (1998) [Pubmed]
  13. Prednisolone inhibits hyperosmolarity-induced expression of MCP-1 via NF-kappaB in peritoneal mesothelial cells. Matsuo, H., Tamura, M., Kabashima, N., Serino, R., Tokunaga, M., Shibata, T., Matsumoto, M., Aijima, M., Oikawa, S., Anai, H., Nakashima, Y. Kidney Int. (2006) [Pubmed]
  14. Acute excitotoxic injury induces expression of monocyte chemoattractant protein-1 and its receptor, CCR2, in neonatal rat brain. Galasso, J.M., Miller, M.J., Cowell, R.M., Harrison, J.K., Warren, J.S., Silverstein, F.S. Exp. Neurol. (2000) [Pubmed]
  15. Sequential cytokine dynamics in chronic rejection of rat renal allografts: roles for cytokines RANTES and MCP-1. Nadeau, K.C., Azuma, H., Tilney, N.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  16. Identification of an inhibitor targeting macrophage production of monocyte chemoattractant protein-1 as TGF-beta 1. Kitamura, M. J. Immunol. (1997) [Pubmed]
  17. Role of transforming growth factor-beta1 in cardiovascular inflammatory changes induced by chronic inhibition of nitric oxide synthesis. Koyanagi, M., Egashira, K., Kubo-Inoue, M., Usui, M., Kitamoto, S., Tomita, H., Shimokawa, H., Takeshita, A. Hypertension (2000) [Pubmed]
  18. Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion molecule-1 following ischemia-reperfusion of the liver in rats. Yamaguchi, Y., Matsumura, F., Takeya, M., Ichiguchi, O., Kuratsu, J.I., Horiuchi, T., Akizuki, E., Matsuda, T., Okabe, K., Ohshiro, H., Liang, J., Mori, K., Yamada, S., Takahashi, K., Ogawa, M. Hepatology (1998) [Pubmed]
  19. Activation of the NF-kappa B and I kappa B system in smooth muscle cells after rat arterial injury. Induction of vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1. Landry, D.B., Couper, L.L., Bryant, S.R., Lindner, V. Am. J. Pathol. (1997) [Pubmed]
  20. Convergence of redox-sensitive and mitogen-activated protein kinase signaling pathways in tumor necrosis factor-alpha-mediated monocyte chemoattractant protein-1 induction in vascular smooth muscle cells. De Keulenaer, G.W., Ushio-Fukai, M., Yin, Q., Chung, A.B., Lyons, P.R., Ishizaka, N., Rengarajan, K., Taylor, W.R., Alexander, R.W., Griendling, K.K. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  21. Different effects of n-6 and n-3 polyunsaturated fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. Bousserouel, S., Brouillet, A., Béréziat, G., Raymondjean, M., Andréani, M. J. Lipid Res. (2003) [Pubmed]
  22. Chylomicron remnants induce monocyte chemoattractant protein-1 expression via p38 MAPK activation in vascular smooth muscle cells. Domoto, K., Taniguchi, T., Takaishi, H., Takahashi, T., Fujioka, Y., Takahashi, A., Ishikawa, Y., Yokoyama, M. Atherosclerosis (2003) [Pubmed]
  23. AT1-receptor antagonists abolish glomerular MCP-1 expression in a model of mesangial proliferative glomerulonephritis. Wolf, G., Schneider, A., Helmchen, U., Stahl, R.A. Exp. Nephrol. (1998) [Pubmed]
  24. Synergistic induction of monocyte chemoattractant protein-1 (MCP-1) by platelet-derived growth factor and interleukin-1. Goppelt-Struebe, M., Stroebel, M. FEBS Lett. (1995) [Pubmed]
  25. Developmental expression of cytokine genes in the cortex and hippocampus of the rat central nervous system. Pousset, F. Brain Res. Dev. Brain Res. (1994) [Pubmed]
  26. Halogenated anesthetics reduce interleukin-1beta-induced cytokine secretion by rat alveolar type II cells in primary culture. Giraud, O., Molliex, S., Rolland, C., Leçon-Malas, V., Desmonts, J.M., Aubier, M., Dehoux, M. Anesthesiology (2003) [Pubmed]
  27. Increased expression of interleukin-1 beta and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload. Shioi, T., Matsumori, A., Kihara, Y., Inoko, M., Ono, K., Iwanaga, Y., Yamada, T., Iwasaki, A., Matsushima, K., Sasayama, S. Circ. Res. (1997) [Pubmed]
  28. Role of CC chemokines (macrophage inflammatory protein-1 beta, monocyte chemoattractant protein-1, RANTES) in acute lung injury in rats. Bless, N.M., Huber-Lang, M., Guo, R.F., Warner, R.L., Schmal, H., Czermak, B.J., Shanley, T.P., Crouch, L.D., Lentsch, A.B., Sarma, V., Mulligan, M.S., Friedl, H.P., Ward, P.A. J. Immunol. (2000) [Pubmed]
  29. Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin. Satofuka, S., Ichihara, A., Nagai, N., Yamashiro, K., Koto, T., Shinoda, H., Noda, K., Ozawa, Y., Inoue, M., Tsubota, K., Suzuki, F., Oike, Y., Ishida, S. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  30. The sources of inflammatory mediators in the lung after silica exposure. Rao, K.M., Porter, D.W., Meighan, T., Castranova, V. Environ. Health Perspect. (2004) [Pubmed]
  31. Increased monocyte chemoattractant protein-1 in knee joints of rats with adjuvant-induced arthritis: in vivo microdialysis. Liu, S.H., Wong, C.S., Chang, D.M. J. Rheumatol. (2005) [Pubmed]
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