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Vigano, A. et al.

Alessandra Vigano, Giorgio Bedogni, Chiara Cerini, Luca Meroni, Vania Giacomet, Sara Stucchi, Valentina Fabiano, Sonia Coletto, Mariella Catalano, Marzio Minola, Gian Vincenzo Zuccotti,

Both HIV-infection and long-term antiretroviral therapy are associated with increased common carotid intima-media thickness in HIV-infected adolescents and young adults.

OBJECTIVE: To evaluate common carotid artery intima-media thickness (CCIMT) and cardiovascular risk factors in HIV-infected adolescents on combination antiretroviral therapy (cART). METHODS: 23 HIV-infected adolescents were matched with 19 healthy subjects by gender, age and body mass index (BMI). CCIMT was measured by Echo-Doppler ultrasound. Bootstrapped multiple linear regression was used to identify potential predictors of CCIMT including HIV status, gender, age, BMI, waist circumference, HDL-cholesterol, LDL- cholesterol, triglycerides, folate, homocysteine, insulin resistance as detected by the homeostasis model assessment, mean blood pressure, and CD36 expression. RESULTS: In the pooled sample, age ranged from 17 to 23 years and BMI between 16.0 and 25.6 kg/m(2). Mean (SD) CCIMT was higher in HIV-infected than in healthy subjects [0.5 (0.1) vs. 0.1 (0.4) mm, p < 0.001]. Higher values of CCIMT were associated with HIV infection (p < 0.001) and male gender (p < 0.001). CCIMT was also associated with the duration of treatment in subjects with the longest cART exposure, i.e. those exposed to a PI-based and/or NNRTI-based regimen plus a single or double NRTI (p = 0.019). CONCLUSION: HIV infection and longer duration of cART are associated with higher CCIMT in adolescents and young adults.[1]

References

Both HIV-infection and long-term antiretroviral therapy are associated with increased common carotid intima-media thickness in HIV-infected adolescents and young adults. Vigano, A., Bedogni, G., Cerini, C., Meroni, L., Giacomet, V., Stucchi, S., Fabiano, V., Coletto, S., Catalano, M., Minola, M., Zuccotti, G.V. Curr. HIV Res. (2010) [Pubmed]

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