- Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. Gilmour, D.T., Lyon, G.J., Carlton, M.B., Sanes, J.R., Cunningham, J.M., Anderson, J.R., Hogan, B.L., Evans, M.J., Colledge, W.H. EMBO J. (1998)