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Chemical Compound Review:

CHEMBL105983 (2S)-2-amino-3-[4-(4-hydroxy- 3-propan-2-yl...

Synonyms: AG-E-82941, SureCN3219487, CHEBI:276337, AC1Q5QKN, CTK4F7784, ...

Bachrach, L.K. et al., Takahashi, T., Takahashi, T., Tamagna, E.I. et al., Loireau, A. et al., et al.

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Disease relevance of 3,5-Dimethyl-3'-isopropyl-L-thyronine

Transplacental effects of 3,5-dimethyl-3'-isopropyl-L-thyronine on fetal hypothyroidism in primates [1].
Treatment of ovine cretinism in utero with 3,5-dimethyl-3'-isopropyl-L-thyronine [2].
Comparative effects of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) and 3,5-diiodo-3'-isopropylthyroacetic acid (IpTA2) on body weight gain and lipid metabolism in genetically obese Zucker rats [3].
When 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) (10 ng/(g X day] was administered to pregnant rats, their infants showed signs of hyperthyroidism with suppressed body weight, tachycardia, and tremor at the day of birth [4].

High impact information on 3,5-Dimethyl-3'-isopropyl-L-thyronine

Maternal administration of a thyroid analog 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) results in significant enhancement of fetal lung phospholipid synthesis and accelerated lung maturity [5].
The thyromimetic activity of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT), a nonhalogenated thyroid analog, was studied in adult men using suppression of TRH-induced TSH release to assess this activity [6].
In an effort to prevent both maternal and fetal hypothyroidism, we treated 131I-treated pregnant monkeys with 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT), a thyroid hormone analog with structural changes which facilitate placental transfer [1].
Maturational effect of triiodothyronine and its analog 3,5-dimethyl-3'-isopropyl-L-thyronine on sucrase activity in the small intestine of the developing rat [7].
3,5-Dimethyl-3'-isopropyl-L-thyronine (DIMIT)-induced fetal hyperthyroid rats showed a marked accumulation of intracellular tubulin content in the cerebral cortex, hypothalamus, and cerebellum at 1 day old [8].

Anatomical context of 3,5-Dimethyl-3'-isopropyl-L-thyronine

The administration of 3,5-dimethyl-3'-isopropyl-L-thyronine had no effect on the retarded fetal brain and body development of the iodine-deficient fetuses [9].

Associations of 3,5-Dimethyl-3'-isopropyl-L-thyronine with other chemical compounds

Prenatal exposure of the fetal rat to excessive L-thyroxine or 3,5-dimethyl-3'-isopropyl-thyronine produces persistent changes in the thyroid control system [10].

Analytical, diagnostic and therapeutic context of 3,5-Dimethyl-3'-isopropyl-L-thyronine

A radioimmunoassay of 3,5-dimethyl-3'-isopropyl-L-thyronine [11].

References

Transplacental effects of 3,5-dimethyl-3'-isopropyl-L-thyronine on fetal hypothyroidism in primates. Bachrach, L.K., Dibattista, D., Burrow, G.N., Holland, F.J. Endocrinology (1983) [Pubmed]
Treatment of ovine cretinism in utero with 3,5-dimethyl-3'-isopropyl-L-thyronine. Bachrach, L.K., Kudlow, J.E., Silverberg, J.D., Kent, G., Burrow, G.N. Endocrinology (1982) [Pubmed]
Comparative effects of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) and 3,5-diiodo-3'-isopropylthyroacetic acid (IpTA2) on body weight gain and lipid metabolism in genetically obese Zucker rats. Loireau, A., Autissier, N., Dumas, P., Michel, O., Jorgensen, E.C., Michel, R. Biochem. Pharmacol. (1986) [Pubmed]
Transplacental effects of 3,5-dimethyl-3'-isopropyl-L-thyronine on tubulin content in fetal brains in rats. Takahashi, T. Jpn. J. Physiol. (1984) [Pubmed]
3,5-Dimethyl-3'-isopropyl-l-thyronine therapy in diabetic pregnancy: stimulation of rabbit fetal lung phospholipids. Neufeld, N., Melmed, S. J. Clin. Invest. (1981) [Pubmed]
Thyrotropin suppression by 3,5-dimethyl-3'-isopropyl-L-thyronine in man. Tamagna, E.I., Hershman, J.M., Jorgensen, E.C. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
Maturational effect of triiodothyronine and its analog 3,5-dimethyl-3'-isopropyl-L-thyronine on sucrase activity in the small intestine of the developing rat. Vaucher, Y.E., Anna, J.A., Lindberg, R.F., Jorgensen, E.C., Krulich, L., Koldovský, O. J. Pediatr. Gastroenterol. Nutr. (1982) [Pubmed]
Effects of fetal thyroid states on RNA, DNA, and tubulin content in neonatal rat brain. Takahashi, T. Jpn. J. Physiol. (1987) [Pubmed]
The effect of thyroxine, 3, 5-dimethyl-3'isopropyl-L-thyronine and iodized oil on fetal brain development in the iodine-deficient sheep. Mano, M.T., Potter, B.J., Belling, G.B., Martin, D.M., Gragg, B.G., Chavadej, J., Hetzel, B.S. Acta Endocrinol. (1989) [Pubmed]
Prenatal exposure of the fetal rat to excessive L-thyroxine or 3,5-dimethyl-3'-isopropyl-thyronine produces persistent changes in the thyroid control system. Porterfield, S.P. Horm. Metab. Res. (1985) [Pubmed]
A radioimmunoassay of 3,5-dimethyl-3'-isopropyl-L-thyronine. Chopra, I.J., Huang, T.S., Hurd, R.E., Solomon, D.H. Endocrinology (1984) [Pubmed]

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