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Chemical Compound Review

Norsertraline     (1S,4S)-4-(3,4- dichlorophenyl)-1,2,3,4...

Synonyms: CHEMBL40733, NAP005, SureCN145234, CHEBI:154601, KST-1A9044, ...
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High impact information on Desmethylsertraline


Biological context of Desmethylsertraline


Anatomical context of Desmethylsertraline


Associations of Desmethylsertraline with other chemical compounds


Gene context of Desmethylsertraline


Analytical, diagnostic and therapeutic context of Desmethylsertraline


  1. Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression. Serebruany, V.L., Suckow, R.F., Cooper, T.B., O'Connor, C.M., Malinin, A.I., Krishnan, K.R., van Zyl, L.T., Lekht, V., Glassman, A.H. The American journal of psychiatry. (2005) [Pubmed]
  2. Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs. Wisner, K.L., Perel, J.M., Blumer, J. The American journal of psychiatry. (1998) [Pubmed]
  3. Sertraline and desmethylsertraline in human breast milk and nursing infants. Stowe, Z.N., Owens, M.J., Landry, J.C., Kilts, C.D., Ely, T., Llewellyn, A., Nemeroff, C.B. The American journal of psychiatry. (1997) [Pubmed]
  4. Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Baumann, P. Clinical pharmacokinetics. (1996) [Pubmed]
  5. Comparison of the effects of sertraline and its metabolite desmethylsertraline on blockade of central 5-HT reuptake in vivo. Sprouse, J., Clarke, T., Reynolds, L., Heym, J., Rollema, H. Neuropsychopharmacology (1996) [Pubmed]
  6. Sertraline treatment of children and adolescents with obsessive-compulsive disorder or depression: pharmacokinetics, tolerability, and efficacy. Alderman, J., Wolkow, R., Chung, M., Johnston, H.F. Journal of the American Academy of Child and Adolescent Psychiatry. (1998) [Pubmed]
  7. Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes. Xu, Z.H., Wang, W., Zhao, X.J., Huang, S.L., Zhu, B., He, N., Shu, Y., Liu, Z.Q., Zhou, H.H. British journal of clinical pharmacology. (1999) [Pubmed]
  8. Coadministration of short-term zolpidem with sertraline in healthy women. Allard, S., Sainati, S.M., Roth-Schechter, B.F. Journal of clinical pharmacology. (1999) [Pubmed]
  9. Inhibition of CYP2C9 by selective serotonin reuptake inhibitors: in vitro studies with tolbutamide and (S)-warfarin using human liver microsomes. Hemeryck, A., De Vriendt, C., Belpaire, F.M. Eur. J. Clin. Pharmacol. (1999) [Pubmed]
  10. Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors? Rasmussen, B.B., Brøsen, K. Therapeutic drug monitoring. (2000) [Pubmed]
  11. The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin. Hamelin, B.A., Turgeon, J., Vallée, F., Bélanger, P.M., Paquet, F., LeBel, M. Clin. Pharmacol. Ther. (1996) [Pubmed]
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