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Chemical Compound Review

Mesigyna     [(8R,9S,10R,13S,14S,17S)-17- ethynyl-13...

Synonyms: Hrp 102, KST-1A0265, AC1L3GZE, AR-1A0622, AC1Q5X69
 
 
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Disease relevance of Hrp 102

  • Based on the results from toxicity testing, there were no objections to the long-term therapeutic use of Mesigyna for hormonal contraception [1].
  • The duration of bleeding days as well as dysmenorrhea were less with Mesigyna [2].
 

High impact information on Hrp 102

 

Chemical compound and disease context of Hrp 102

 

Biological context of Hrp 102

  • After a single injection of Cyclofem and Mesigyna, both formulations showed equal contraceptive effect with inhibition of follicle maturation for some 30 days and ovulation, corpus luteum formation for some 60 days [4].
  • In order to attain predictable menstrual cycle control as well as high efficacy with a 30-day injection schedule, two improved once-a-month injectable formulations, Cyclofem and Mesigyna, were developed [4].
 

Associations of Hrp 102 with other chemical compounds

  • Thereafter, 50% of Mesigyna users had precisely 3 bleeding/spotting episodes every 90 days, 50% of Cyclofem users had 2-3 and 50% of Injectable No. 1 users had 3-4 episodes every 90 days [5].
 

Analytical, diagnostic and therapeutic context of Hrp 102

  • The objective of this study was to determine the effects of a once-monthly injectable contraceptive (Mesigyna) on menstrual pattern, lipoproteins, and coagulation parameters [6].
  • The incidence of bleeding anomalies was higher in the Mesigyna group, with a discontinuation rate for these reasons of 20% versus 4% for IUD (p <0.05) [2].

References

 
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