The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Premenopause

  • We studied the potential association between BMD and VDR genotypes in females from prepuberty to premenopause and prospectively investigated the interaction of VDR genotypes with dietary calcium and BMD changes during childhood [1].
  • Musculo-skeletal pain pre-menopause was significantly related to estradiol [2].
  • Whereas post-menopause DHEA-S levels were influenced by pain scores, no significant effect of pre-menopause hormones on post-menopause pain and distress was found [2].
  • This possibly reflects selection and modifying effects on incidence and survival of hormone dependency of a proportion of breast cancers, the growth of which could be accelerated during the premenopause and the survival favourably influenced by the decline in steroid hormone levels after the menopause [3].
  • Significant increase in serum calcium, phosphate and calcitonin and urine calcium/creatinine and TmPO4/GF were shown to precede the premenopause [4].

Biological context of Premenopause

  • CONCLUSION: This study demonstrates that the previously described sexual dimorphism in cortisol metabolism is not dependent on oestrogen, although the possibility that oestrogen exerts a permanent modifying effect on 11beta-HSD1 gene expression during the pre-menopausal period cannot be excluded [5].
  • During the premenopausal period an increasing frequency of inadequate luteal function or anovulation occurred and, in the postmenopausal years, the serum levels of progesterone (P) were invariably low [6].
  • Women in premenopause want to know what to expect; women in perimenopause want to know that their experiences fall within the range of 'normal'; women in peri- and postmenopause need help in making sensible decisions about the use of hormone therapy [7].
  • Studies were performed in younger (age 20-28 years, n = 8) and older (age 40-48 years, n = 8) subjects with normal menstrual cycles and normal gonadal steroid levels to avoid the interference of premenopause or menopause on gonadotropin secretion [8].

Associations of Premenopause with chemical compounds


Gene context of Premenopause

  • In premenopause, there was a weak negative correlation between ER and E2 levels [13].
  • At pre-menopause, obese women had lower PR levels than non obese (P<.006) [14].
  • The expression in normal ovaries was significantly higher (p < 0.01) in premenopause, suggesting the predominance of a sex steroid hormone effect on ovarian SHBG synthesis [15].
  • Menopause does not appear to be associated with differences in CYP3A4 activity, compared with premenopause [16].
  • Even in the women around the menopausal, CETP concentration in postmenopause was significantly lower than that in premenopause (1.93+/-1.33 vs. 3.42+/-1.35 mg/l, P<0.01) [17].

Analytical, diagnostic and therapeutic context of Premenopause


  1. Do dietary calcium and age explain the controversy surrounding the relationship between bone mineral density and vitamin D receptor gene polymorphisms? Ferrari, S.L., Rizzoli, R., Slosman, D.O., Bonjour, J.P. J. Bone Miner. Res. (1998) [Pubmed]
  2. Musculo-skeletal pain, psychological distress, and hormones during the menopausal transition. Finset, A., Øverlie, I., Holte, A. Psychoneuroendocrinology (2004) [Pubmed]
  3. Breast cancer survival in relation to sex and age. Levi, F., Randimbison, L., La Vecchia, C. Oncology (1992) [Pubmed]
  4. A longitudinal study of pre- and postmenopausal changes in calcium metabolism. Falch, J.A., Gautvik, K.M. Bone (1988) [Pubmed]
  5. Sexual dimorphism of cortisol metabolism is maintained in elderly subjects and is not oestrogen dependent. Toogood, A.A., Taylor, N.F., Shalet, S.M., Monson, J.P. Clin. Endocrinol. (Oxf) (2000) [Pubmed]
  6. A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density. Rannevik, G., Jeppsson, S., Johnell, O., Bjerre, B., Laurell-Borulf, Y., Svanberg, L. Maturitas. (1995) [Pubmed]
  7. Reassuring the woman facing menopause: strategies and resources. Cobb, J.O. Patient education and counseling. (1998) [Pubmed]
  8. Age-related decrease in the opioid control of LH secretion during reproductive years in normal women. Coiro, V., Volpi, R., Gramellini, D., Cigarini, C., Magotti, M.G., Caffarri, G., Chiodera, P. Gynecol. Obstet. Invest. (1997) [Pubmed]
  9. Repeated serum and urinary androgen measurements in premenopausal and postmenopausal women. Micheli, A., Muti, P., Pisani, P., Secreto, G., Recchione, C., Totis, A., Fissi, R., Cavalleri, A., Panico, S., Berrino, F. Journal of clinical epidemiology. (1991) [Pubmed]
  10. Effect of menopause and hormone replacement therapy on urinary excretion of pyridinium cross-links: a longitudinal and cross-sectional study. Hassager, C., Colwell, A., Assiri, A.M., Eastell, R., Russell, R.G., Christiansen, C. Clin. Endocrinol. (Oxf) (1992) [Pubmed]
  11. Plasma estrone sulfate levels in postmenopausal women. Roberts, K.D., Rochefort, J.G., Bleau, G., Chapdelaine, A. Steroids (1980) [Pubmed]
  12. 7-Hydroxydehydroepiandrosterone epimers in the life span. Hampl, R., Hill, M., Stárka, L. J. Steroid Biochem. Mol. Biol. (2001) [Pubmed]
  13. Changing estrogen and progesterone receptor patterns in breast carcinoma during the menstrual cycle and menopause. Pujol, P., Daures, J.P., Thezenas, S., Guilleux, F., Rouanet, P., Grenier, J. Cancer (1998) [Pubmed]
  14. Factors associated with estrogen receptors-alpha (ER-alpha) and -beta (ER-beta) and progesterone receptor abundance in obese and non obese pre- and post-menopausal women. Meza-Muñoz, D.E., Fajardo, M.E., Pérez-Luque, E.L., Malacara, J.M. Steroids (2006) [Pubmed]
  15. Expression of sex hormone-binding globulin mRNA in human ovarian cancers. Misao, R., Nakanishi, Y., Fujimoto, J., Hori, M., Ichigo, S., Tamaya, T. Eur. J. Endocrinol. (1995) [Pubmed]
  16. Cytochrome P450 3A4 activity in premenopausal and postmenopausal women, based on 6-beta-hydroxycortisol:cortisol ratios. Burstein, A.H., Reiss, W.G., Kantor, E., Anderson, G.D. Pharmacotherapy (1998) [Pubmed]
  17. Relationship between endogenous estrogen concentrations and serum cholesteryl ester transfer protein concentrations in Chinese women. Zhang, C., Zhuang, Y., Qiang, H., Liu, X., Xu, R., Wu, Y. Clin. Chim. Acta (2001) [Pubmed]
  18. Background factors influencing somatic and psychological symptoms in middle-age women with different hormonal status. A population-based study of Swedish women. Li, C., Borgfeldt, C., Samsioe, G., Lidfeldt, J., Nerbrand, C. Maturitas. (2005) [Pubmed]
  19. Differences in regional immunoreactivity during the premenopausal and postmenopausal periods in patients with carcinoma of the breast. Wernicke, M., Bazan, G.E. Surgery, gynecology & obstetrics. (1977) [Pubmed]
WikiGenes - Universities