Disease relevance of N-methyl-N-phenyl-nitrous amide

• RESULTS: Morphological features of the chronic esophagitis in this patient were similar to the precancerous lesions from high-risk areas for esophageal squamous cancer and the precancerous lesions induced in rats by N-methyl-N-nitrosoaniline [1].
• The time to death of the NMA-NMEA group was not affected by the NMA treatment, but many of the animals had esophageal neoplasms [2].
• The present study examines the feasibility of using the Salmonella typhimurium plate-incorporation assay of Ames for detecting target-organ specificity with N-nitroso-N-methylaniline (NMA), a compound for which the target site for tumour formation in the rat is the oesophagus [3].

High impact information on N-methyl-N-phenyl-nitrous amide

• When tested with any of the S9 or hepatocyte preparations, nitrosodiphenylamine and nitrosomethylaniline, also reported to be carcinogens but not mutagens, gave no mutagenic responses [4].
• The steady state kinetics and isotope effects were examined for demethylation of dimethylnitrosamine and phenylmethylnitrosamine, as well as their deuterated analogs, using the S-9 fraction, the microsomal pellet, and postmicrosomal supernatant from rat livers [5].
• The N-demethylation of 15N-labeled N-nitrosodimethylamine (DMN) and N-nitroso-N-methylaniline (NMA) by isolated rat hepatic cells has been investigated [6].
• The effects of S9 mix from rat oesophagus, salivary gland, and liver on the mutagenicity of the rat oesophageal carcinogen N-nitroso-N-methylaniline in the Salmonella typhimurium assay [3].
• These data were used to estimate the participation of the CYP preparation and peroxidase C in oxidation of two out of the four studied xenobiotics (NMA, Sudan I) in tulip microsomes [7].

Biological context of N-methyl-N-phenyl-nitrous amide

• The metabolic activation of the esophageal carcinogen methylphenylnitrosamine (MPhN) via alpha-hydroxylation to hydroxymethylphenylnitrosamine (HO-MPhN) should afford benzenediazonium ion (BDI) as the ultimate electrophilic metabolite [8].
• Oxidative dealkylation and reductive denitrosation of nitrosomethylaniline in vitro [9].

Anatomical context of N-methyl-N-phenyl-nitrous amide

• The enzymatic denitrosation of N-nitroso-N-methylaniline (NMA) was investigated by measuring the resulting amine metabolites when NMA was incubated with liver microsomes of PB-pretreated mice [10].
• An investigation of the metabolism of N-nitroso-N-methylaniline by phenobarbital- and pyrazole-induced Sprague-Dawley rat liver and esophagus derived S-9 [11].

Associations of N-methyl-N-phenyl-nitrous amide with other chemical compounds

• Both enzymes in the presence of dilauroyl phosphatidylcholine and NADPH were able to oxidize xenobiotics (N-nitroso-N-methylaniline and N-nitroso-N-dimethylamine) in the reconstitution experiments [12].

References