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Chemical Compound Review

NSC-137     N-methyl-N-phenyl-nitrous amide

Synonyms: CCRIS 400, NSC137, CHEMBL266169, AG-G-23708, ACMC-209mse, ...
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Disease relevance of N-methyl-N-phenyl-nitrous amide

  • RESULTS: Morphological features of the chronic esophagitis in this patient were similar to the precancerous lesions from high-risk areas for esophageal squamous cancer and the precancerous lesions induced in rats by N-methyl-N-nitrosoaniline [1].
  • The time to death of the NMA-NMEA group was not affected by the NMA treatment, but many of the animals had esophageal neoplasms [2].
  • The present study examines the feasibility of using the Salmonella typhimurium plate-incorporation assay of Ames for detecting target-organ specificity with N-nitroso-N-methylaniline (NMA), a compound for which the target site for tumour formation in the rat is the oesophagus [3].

High impact information on N-methyl-N-phenyl-nitrous amide


Biological context of N-methyl-N-phenyl-nitrous amide


Anatomical context of N-methyl-N-phenyl-nitrous amide


Associations of N-methyl-N-phenyl-nitrous amide with other chemical compounds


  1. Chronic esophagitis evolving to verrucous squamous cell carcinoma: possible role of exogenous chemical carcinogens. Kavin, H., Yaremko, L., Valaitis, J., Chowdhury, L. Gastroenterology (1996) [Pubmed]
  2. Carcinogenic effects of sequential administration of two nitrosamines in Fischer 344 rats. Michejda, C.J., Kroeger-Koepke, M.B., Kovatch, R.M. Cancer Res. (1986) [Pubmed]
  3. The effects of S9 mix from rat oesophagus, salivary gland, and liver on the mutagenicity of the rat oesophageal carcinogen N-nitroso-N-methylaniline in the Salmonella typhimurium assay. Anderson, D., Blowers, S.D., Craddock, V.M. Mutat. Res. (1985) [Pubmed]
  4. Greater effectiveness of hepatocyte and liver S9 preparations from hamsters than rat preparations in activating N-nitroso compounds to metabolites mutagenic to Salmonella. Raineri, R., Poiley, J.A., Andrews, A.W., Pienta, R.J., Lijinsky, W. J. Natl. Cancer Inst. (1981) [Pubmed]
  5. Evidence for several demethylase enzymes in the oxidation of dimethylnitrosamine and phenylmethylnitrosamine by rat liver fractions. Kroeger-Koepke, M.B., Michejda, C.J. Cancer Res. (1979) [Pubmed]
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  7. Oxidation of xenobiotics by plant microsomes, a reconstituted cytochrome P450 system and peroxidase: a comparative study. Stiborová, M., Schmeiser, H.H., Frei, E. Phytochemistry (2000) [Pubmed]
  8. Carcinogenicity tests of acetoxymethylphenylnitrosamine and benzenediazonium tetrafluoroborate in Syrian hamsters. Gold, B., Salmasi, S. Cancer Lett. (1982) [Pubmed]
  9. Oxidative dealkylation and reductive denitrosation of nitrosomethylaniline in vitro. Appel, K.E., Rühl, C.S., Hildebrandt, A.G. Chem. Biol. Interact. (1985) [Pubmed]
  10. Metabolic denitrosation of N-nitroso-N-methylaniline: detection of amine-metabolites. Scheper, T., Appel, K.E., Schunack, W., Somogyi, A., Hildebrandt, A.G. Chem. Biol. Interact. (1991) [Pubmed]
  11. An investigation of the metabolism of N-nitroso-N-methylaniline by phenobarbital- and pyrazole-induced Sprague-Dawley rat liver and esophagus derived S-9. Gold, B., Farber, J., Rogan, E. Chem. Biol. Interact. (1987) [Pubmed]
  12. Isolation of plant cytochrome P-450 and NADPH: cytochrome P-450 reductase from tulip bulbs (Tulipa fosteriana L.) oxidizing xenobiotics. Hansíková, H., Frei, E., Anzenbacher, P., Stiborová, M. Gen. Physiol. Biophys. (1994) [Pubmed]
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