High impact information on splenopentin

• Splenin and splenopentin, in contrast, do not affect neuromuscular transmission, and they induce both T- and B-cell precursors [1].
• Cytofluorometric and cytomorphologic analysis of human bone marrow cells derived from stromal cultures stimulated by granulocyte-macrophage colony-stimulating factor, interferon-gamma and splenopentin pentapeptide [2].
• Augmentation of human natural killer cells by splenopentin analogs [3].
• Stimulation of IL-2 production and CD2R expression by splenopentin analogs [4].
• Splenopentin (SP-5), is a pentapeptide corresponding to the amino acid sequence 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin [4].

Biological context of splenopentin

• Effect of splenopentin (SP-5) on the antibody formation in immunosuppressed mice [5].
• Prevention of graft-vs-host reaction induced immunodeficiency by treatment with splenopentin (DAc-SP5) [6].
• Upregulation of HLA class-I gene transcription in K562 cells by analogs of splenopentin (SP-5) [7].

Anatomical context of splenopentin

• Stimulation of the recruitment of epidermal Langerhans cells by splenopentin [8].
• Splenopentin (DAc-SP-5) accelerates the restoration of myelopoietic and immune systems after sublethal radiation in mice [9].
• Early experiments had shown that splenopentin, the active part of the splenic hormone splenin, stimulates the differentiation of virgin B- and T-lymphocytes and significantly enhanced the reconstitution of immune reactions after immune suppression [6].
• Sublethally irradiated C57Bl/6 mice (whole body irradiation with 600 cGy) were treated with or without diacetyl splenopentin and compared for their capacity to produce antibodies against target sheep red blood cells [5].
• Histamine receptor-bearing lymphocytes (HRL). VIII. Splenopentin-accelerated reconstitution of the immunoresponsiveness after elimination of HRL [10].

Associations of splenopentin with other chemical compounds

• Splenopentin (DA SP-5) is a pentapeptide corresponding to the amino acid sequence 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin [11].
• Aminopeptidase N purified from human placenta actively hydrolyzed various immunomodulating peptides from their N-terminus such as splenopentin, thymopentin, thymic humoral factor gamma 2, tuftsin and rigin in vitro [12].

Analytical, diagnostic and therapeutic context of splenopentin

• Splenopentin-induced reconstitution of the immune response after total body irradiation: optimization of treatment regime [13].
• Therefore, before application of DAc-SP5 to the bone marrow transplantation in humans in order to improve the engraftment, parameters have to be found which allow an exact prediction about the influence of splenopentin on the GVHR in each single case [14].
• In former investigations our group obtained an immuno-reconstituting effect in mice treated by immunosuppression after a continuous treatment with splenopentin (SP5) [13].

References