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Chemical Compound Review

CHEMBL40998     3-(decyl-dimethyl-silyl)-N- [2-(4...

Synonyms: Sandoz 58035, AG-H-16417, SureCN4430655, Sandoz 58-035, S9318_SIGMA, ...
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Disease relevance of San 58-035

  • Compound 58-035 (3-[decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenylethyl]pro panamide) has been found to inhibit the accumulation of cholesteryl esters in both rat hepatoma (Fu5AH) cells and arterial smooth muscle cells in culture [1].

High impact information on San 58-035


Biological context of San 58-035


Anatomical context of San 58-035


Gene context of San 58-035


  1. Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035. Ross, A.C., Go, K.J., Heider, J.G., Rothblat, G.H. J. Biol. Chem. (1984) [Pubmed]
  2. Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol. Warner, G.J., Stoudt, G., Bamberger, M., Johnson, W.J., Rothblat, G.H. J. Biol. Chem. (1995) [Pubmed]
  3. Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester. Wu, X., Sakata, N., Lui, E., Ginsberg, H.N. J. Biol. Chem. (1994) [Pubmed]
  4. Role of the neutral lipid accessible pool in the regulation of secretion of apoB-100 lipoprotein particles by HepG2 cells. Avramoglu, R.K., Cianflone, K., Sniderman, A.D. J. Lipid Res. (1995) [Pubmed]
  5. Triglyceride and cholesteryl ester hydrolysis in a cell culture model of smooth muscle foam cells. Minor, L.K., Rothblat, G.H., Glick, J.M. J. Lipid Res. (1989) [Pubmed]
  6. The role of cholesterol esterification in ovarian steroidogenesis: studies in cultured swine granulosa cells using a novel inhibitor of acyl coenzyme A: cholesterol acyltransferase. Veldhuis, J.D., Strauss, J.F., Silavin, S.L., Kolp, L.A. Endocrinology (1985) [Pubmed]
  7. Cellular free cholesterol in Hep G2 cells is only partially available for down-regulation of low-density-lipoprotein receptor activity. Havekes, L.M., de Wit, E.C., Princen, H.M. Biochem. J. (1987) [Pubmed]
  8. Application of 2-hydroxypropyl-beta-cyclodextrin in the assay of acyl-CoA:cholesterol acyltransferase and neutral and acid cholesterol ester hydrolases. Liza, M., Romero, J.R., Chico, Y., Fresnedo, O., Ochoa, B. Lipids (1996) [Pubmed]
  9. Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat. Williams, R.J., McCarthy, A.D., Sutherland, C.D. Biochim. Biophys. Acta (1989) [Pubmed]
  10. Accumulation of oleate-rich cholesteryl esters by acetyl-LDL in macrophages in the presence of an acyl-CoA: cholesterol acyltransferase inhibitor (Sandoz 58-035). Shimasaki, O., Mineo, C., Mowri, H., Ohkuma, S., Takano, T. Biochem. Int. (1990) [Pubmed]
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