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Chemical Compound Review:

RPCH (2S)-N-[(1S)-1-[[(2S)-1- [(2S)-2-[[(1S)-1...

Synonyms: AC1L3XPG, CTK8D4750, AR-1G9328, AC1Q6PB2, 37933-92-9, ...

Granato, F.C. et al., Jaffe, H. et al., Martínez-Pérez, F. et al., Dickinson, P.S. et al., Yang, W.J. et al., et al.

Dickinson, Hauptman, Hetling, Mahadevan,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of p-Glu-leu-asn-phe-ser-pro-gly-trp-amide

RPCH intensifies this interaction by increasing the strength of the synaptic connections between the IV neurons and their targets in the stomatogastric ganglion [1].

High impact information on p-Glu-leu-asn-phe-ser-pro-gly-trp-amide

At 50% of embryonic development (E50), all three peptides stain the commissural ganglia and brain, but only RPCH- and proctolin-like immunoreactivities stain axonal arbors in the STG [2].
The amplitude of the excitatory postsynaptic potentials from the IV neurons to the cardiac sac dilator neuron CD2 (1 of the 2 major motor neurons in the cardiac sac system) was potentiated in the presence of both proctolin and RPCH [3].
Red pigment-concentrating hormone (RPCH) induces pigment aggregation in shrimp chromatophores via an increase in intracellular Ca(2+); however, how this increase is brought about is not known [4].
The open reading frame (ORF) of the gene for the precursor of the octapeptide Red Pigment Concentrating Hormone (RPCH) from the blue crab Callinectes sapidus was cloned by PCR with oligonucleotides targeted to the initiation and the end of the translation coding sequences [5].
The circadian rhythm of black pigment migration of melanophores of the crab Chasmagnathus granulata and the variation in responsiveness of these cells to pigment-dispersing hormone (beta-PDH), crustacean cardioactive peptide (CCAP), and red pigment-concentrating hormone (RPCH) were investigated [6].

Biological context of p-Glu-leu-asn-phe-ser-pro-gly-trp-amide

One of them was found to show pigment concentrating activity and to have an amino acid sequence identical with that of the known red pigment concentrating hormone (RPCH), and therefore it was named Pej-RPCH [7].

Anatomical context of p-Glu-leu-asn-phe-ser-pro-gly-trp-amide

Isolation of crustacean erythrophore concentrating hormone from nerve tissue of Homarus americanus [8].
Red pigment-concentrating hormone (RPCH) and Cancer borealis tachykinin-related peptide (CabTRP) are colocalized in a pair of fibers that project into the neuropil of the STG [9].

Associations of p-Glu-leu-asn-phe-ser-pro-gly-trp-amide with other chemical compounds

Two structurally related arthropod neuropeptides, red pigment concentrating hormone (RPCH) and adipokinetic hormone (AKH), are potent excitors of the heart of the clam Mercenaria mercenaria [10].

Analytical, diagnostic and therapeutic context of p-Glu-leu-asn-phe-ser-pro-gly-trp-amide

Crustacean erythrophore concentrating hormone (CECH) was isolated from lobster (Homarus americanus) eyestalks by reverse phase high-performance liquid chromatography (rp-hplc) [8].

References

RCPH modulation of a multi-oscillator network: effects on the pyloric network of the spiny lobster. Dickinson, P.S., Hauptman, J., Hetling, J., Mahadevan, A. J. Neurophysiol. (2001) [Pubmed]
Sequential developmental acquisition of neuromodulatory inputs to a central pattern-generating network. Fénelon, V.S., Kilman, V., Meyrand, P., Marder, E. J. Comp. Neurol. (1999) [Pubmed]
Neurotransmitter interactions in the stomatogastric system of the spiny lobster: one peptide alters the response of a central pattern generator to a second peptide. Dickinson, P.S., Fairfield, W.P., Hetling, J.R., Hauptman, J. J. Neurophysiol. (1997) [Pubmed]
Calcium movements during pigment aggregation in freshwater shrimp chromatophores. Ribeiro, M., McNamara, J.C. Pigment Cell Res. (2007) [Pubmed]
The genomic organization of the open reading frame of the red pigment concentrating hormone gene in the blue crab Callinectes sapidus. Martínez-Pérez, F., Valdés, J., Zinker, S., Aréchiga, H. Peptides (2002) [Pubmed]
Circadian rhythm of pigment migration induced by chromatrophorotropins in melanophores of the crab Chasmagnathus granulata. Granato, F.C., Tironi, T.S., Maciel, F.E., Rosa, C.E., Vargas, M.A., Nery, L.E. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2004) [Pubmed]
Characterization of chromatophorotropic neuropeptides from the kuruma prawn Penaeus japonicus. Yang, W.J., Aida, K., Nagasawa, H. Gen. Comp. Endocrinol. (1999) [Pubmed]
Isolation of crustacean erythrophore concentrating hormone from nerve tissue of Homarus americanus. Jaffe, H., Loeb, M., Hayes, D.K., Talbot, N., Garvick, S. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1984) [Pubmed]
Colocalized neuropeptides activate a central pattern generator by acting on different circuit targets. Thirumalai, V., Marder, E. J. Neurosci. (2002) [Pubmed]
Cross-phyletic bioactivity of arthropod neurohormones and molluscan ganglion extracts: evidence of an extended peptide family. Greenberg, M.J., Rao, K.R., Lehman, H.K., Price, D.A., Doble, K.E. J. Exp. Zool. (1985) [Pubmed]

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