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Disease relevance of Mercenaria


High impact information on Mercenaria

  • Mercenaria myosin and scallop pure hybrid myosin possessing Mercenaria regulatory light chains were reacted with various concentrations of 4-4'-dimaleimidylstilbene-2-2'-disulfonic acid (DMSDS) [5].
  • This indicates the absence of free sulfhydryl groups in the regulatory light chain homodimer and suggests, therefore, that DMSDS links the two light chains together between translationally equivalent residues (Cys-50 of the Mercenaria regulatory light chain) [5].
  • Treatment of the 14C-labeled product with alpha-fucosidase (Venus mercenaria) or weak acid at 100 degrees C for 2 h released 80-90% of the bound radioactive fucose [6].
  • Scallop regulatory light chains cross-linked extensively (20 to 50%) with Mercenaria regulatory light chains (cysteine in position approximately 50) in solutions that induce rigor in skinned fibers (no ATP) and in relaxing solutions (ATP but no Ca2+) [7].
  • An anti-cancer peptide was purified from the Mercenaria (Meretrix meretrix Linnaeus) by the method of chromatography on Sephadex G-25 and FPLC, and its molecular weight was determined to be 3147 Da by the way of MALDI-TOF mass spectrum [8].

Biological context of Mercenaria


Anatomical context of Mercenaria


Associations of Mercenaria with chemical compounds


Gene context of Mercenaria

  • A new cytochrome P450 (CYP30) family identified in the clam, Mercenaria mercenaria [21].
  • Dimers incorporating essential light chains were not formed upon reaction of DMSDS with Mercenaria myosin but some (less than 5%) essential light chain homodimers were obtained in the case of scallop hybrid myosin, probably occurring through relatively specific intermolecular associations within small myosin aggregates [5].
  • Experiments were conducted with Y-organs in vitro from the crab, Menippe mercenaria, in the presence of labeled cholesterol, with or without the steroid 5 alpha-reductase inhibitor, L-645390 (Merck) [22].
  • The activities of both the lateral and frontal cilia of Mercenaria mercenaria were unaffected, either by the two endogenous SCP-related peptides AMSFYFPRMamide and YFAFPRQamide, or by FMRFamide (all at 10(-6) M) [23].
  • PCB residues in Mercenaria mercenaria from New Bedford Harbor, 1978 [24].


  1. Detection of hepatitis A virus in Mercenaria mercenaria by coupled reverse transcription and polymerase chain reaction. Goswami, B.B., Koch, W.H., Cebula, T.A. Appl. Environ. Microbiol. (1993) [Pubmed]
  2. Patterns of energy metabolism in the stone crab, Menippe mercenaria, during severe hypoxia and subsequent recovery. Albert, J.L., Ellington, W.R. J. Exp. Zool. (1985) [Pubmed]
  3. Halophilic Vibrio spp. associated with hard clams (Mercenaria spp.) from the Calabar river estuary. Utsalo, S.J., Mboto, C.I., Gemade, E.I., Nwangwa, M.A. Trans. R. Soc. Trop. Med. Hyg. (1988) [Pubmed]
  4. Acute toxicity of tributyltin (TBT) to early life history stages of the hard shell clam, Mercenaria mercenaria. Laughlin, R.B., Gustafson, R.G., Pendoley, P. Bulletin of environmental contamination and toxicology. (1989) [Pubmed]
  5. Cross-linking between translationally equivalent sites on the two heads of myosin. Relationship to energy transfer results between the same pair of sites. Chantler, P.D., Bower, S.M. J. Biol. Chem. (1988) [Pubmed]
  6. Biosynthesis in vitro of a blood group B-active fucose-containing hexaglycosylceramide from neolactopentaosylceramide in bovine spleen. Presper, K.A., Basu, M., Basu, S. J. Biol. Chem. (1982) [Pubmed]
  7. Proximity of regulatory light chains in scallop myosin. Hardwicke, P.M., Szent-Györgyi, A.G. J. Mol. Biol. (1985) [Pubmed]
  8. Inhibitory effects of anticancer peptide from Mercenaria on the BGC-823 cells and several enzymes. Leng, B., Liu, X.D., Chen, Q.X. FEBS Lett. (2005) [Pubmed]
  9. Hemocyte-derived reactive oxygen intermediate production in four bivalve mollusks. Anderson, R.S. Dev. Comp. Immunol. (1994) [Pubmed]
  10. Bioavailability of the organophosphorous insecticide chlorpyrifos to the suspension-feeding bivalve, Mercenaria mercenaria, following exposure to dissolved and particulate matter. Bejarano, A.C., Widenfalk, A., Decho, A.W., Chandler, G.T. Environ. Toxicol. Chem. (2003) [Pubmed]
  11. Hydrogen sulfide is synthesized in the gills of the clam Mercenaria mercenaria and acts seasonally to modulate branchial muscle contraction. Gainey, L.F., Greenberg, M.J. Biol. Bull. (2005) [Pubmed]
  12. Induction of glutathione-S-transferase in the Northern quahog Mercenaria mercenaria after exposure to the polychlorinated biphenyl (PCB) mixture Aroclor 1248. Blanchette, B.N., Singh, B.R. J. Protein Chem. (2002) [Pubmed]
  13. Competitive inhibition by dimethylsulfoxide of molluscan and vertebrate acetylcholinesterase. Plummer, J.M., Greenberg, M.J., Lehman, H.K., Watts, J.A. Biochem. Pharmacol. (1983) [Pubmed]
  14. A novel putative tyrosinase involved in periostracum formation from the pearl oyster (Pinctada fucata). Zhang, C., Xie, L., Huang, J., Chen, L., Zhang, R. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  15. Calcium speciation and exchange between blood and extrapallial fluid of the quahog Mercenaria mercenaria (L.). Nair, P.S., Robinson, W.E. Biol. Bull. (1998) [Pubmed]
  16. Viscoelastic properties of very dilute paramyosin solutions. Rosser, R.W., Schrag, J.L., Ferry, J.D., Greaser, M. Macromolecules (1977) [Pubmed]
  17. Immunohistochemical localization and radioenzymatic measurements of serotonin (5-hydroxytryptamine) in hearts of Aplysia and several bivalve mollusks. Ono, J.K., Hampton, J.D., Koch, R.A. Cell Tissue Res. (1992) [Pubmed]
  18. Anticoagulantly active heparin from clam (Mercenaria mercenaria). Jordan, R.E., Marcum, J.A. Arch. Biochem. Biophys. (1986) [Pubmed]
  19. Analysis of glycosphingolipids by fluorophore-assisted carbohydrate electrophoresis using ceramide glycanase from Mercenaria mercenaria. Basu, S.S., Dastgheib-Hosseini, S., Hoover, G., Li, Z., Basu, S. Anal. Biochem. (1994) [Pubmed]
  20. Influence of alpha- and beta-adrenergic antagonists on dopamine-induced responses in the isolated heart of Mercenaria mercenaria. Mann, D.E., Gautieri, R.F. Journal of pharmaceutical sciences. (1984) [Pubmed]
  21. A new cytochrome P450 (CYP30) family identified in the clam, Mercenaria mercenaria. Brown, D.J., Clark, G.C., Van Beneden, R.J. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1998) [Pubmed]
  22. Biosynthesis of ecdysteroid hormones by crustacean Y-organs: conversion of cholesterol to 7-dehydrocholesterol is suppressed by a steroid 5 alpha-reductase inhibitor. Spaziani, E., Wang, W.L. Mol. Cell. Endocrinol. (1993) [Pubmed]
  23. An endogenous SCP-related peptide modulates ciliary beating in the gills of a venerid clam, Mercenaria mercenaria. Gainey, L.F., Vining, K.J., Doble, K.E., Waldo, J.M., Candelario-Martinez, A., Greenberg, M.J. Biol. Bull. (1999) [Pubmed]
  24. PCB residues in Mercenaria mercenaria from New Bedford Harbor, 1978. Deubert, K.H., Rule, P., Corte-Real, I. Bulletin of environmental contamination and toxicology. (1981) [Pubmed]
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