High impact information on CLOPENTHIXOL

• On the contrary, changes in alpha 1, observed 6 hr after the administration of a single test dose of either haloperidol or clopenthixol, discriminated to a very large extent between R and NR, correctly identifying 17 out of 18 R and 8 out of 10 NR [1].
• Molecular structure and dynamics of cis(Z)-and trans(E)-flupenthixol and clopenthixol [2].
• Effects of butaclamol, clopenthixol, mepromazine and cannabinol stereoisomers on apoptosis induction [3].
• The clopenthixol stereoisomers, but not the chlorprothixene isomers, inhibited colour change at concentrations lower than those which inhibited growth [4].
• Based on these results, tricyclic compounds does not seem to have stereoselectivity in methotrimeprazine and clopenthixol on the mdr reversal effect [5].

Biological context of CLOPENTHIXOL

• Rapid hydrolysis to clopenthixol in the organism was indicated by in vitro experiments and in vivo findings [6].
• Enhancement of human neutrophil chemotaxis and possibly of the antibacterial activity of these cells by CPZ and the stereo-isomeric compounds of clopenthixol may have clinical implications especially in immunocompromised hosts [7].
• The clopenthixol formed by hydrolysis appeared to be metabolized in the same way as clopenthixol given orally i.e. by dealkylation of the side chain and by S-oxide and N-oxide formation [6].

Associations of CLOPENTHIXOL with other chemical compounds

• A 5-year follow-up study of chronic schizophrenics treated with clopenthixol decanoate [8].
• The serum concentrations of cis(Z)- and trans(E)-clopenthixol have been estimated in human volunteers by an HPLC-method after administration of a clopenthixol tablet, which contains the cis(Z)- and the trans(E)-isomers in the ratio 1/2, or a cis(Z)-clopenthixol tablet [9].
• We found some differences favouring the control groups for adverse effects.One study (Ahlfors 1980) of six months' duration (n=172), compared perphenazine enanthate to clopenthixol decanoate [10].

Analytical, diagnostic and therapeutic context of CLOPENTHIXOL

• In addition serum data are presented for patients treated with intramuscular injections of 100-600 mg clopenthixol decanoate in Viscoleo every second week [11].

References