Disease relevance of Griseolic acid A

• The morphological change of several neuroblastoma cell lines induced by griseolic acid, a novel and potent inhibitor of cyclic nucleotide phosphodiesterase (PDE), was examined [1].

High impact information on Griseolic acid A

• Multiple neurite formation in neuroblastoma cell lines by griseolic acid, a potent inhibitor of cyclic nucleotide phosphodiesterases [1].
• The effects of griseolic acid (GA), a cyclic-AMP phosphodiesterase (PDE) inhibitor, and its 8'-pivaloyloxymethyl (POM) ester on intraocular pressure (IOP) in rabbits were investigated [2].
• The structure of griseolic acid, adenine nucleoside type structure, was elucidated by chemical degradation and X-ray analysis, and was shown to be structure 1 [3].
• A novel phosphodiesterase inhibitor, griseolic acid, suppresses basal phosphodiesterase activity (approximately 50%), increases cellular cAMP content, and stimulates lipolysis in intact fat cells [4].
• Effects of a cyclic AMP phosphodiesterase inhibitor, 8'-pivaloyloxymethyl ester of griseolic acid, on aqueous humor dynamics in rabbits [5].

Biological context of Griseolic acid A

• Griseolic acid derivatives having a different substituent at the N1,C6,C2' or C7' position of the natural product were synthesized and their structure activity relationship to cyclic nucleotide phosphodiesterase inhibitory activity was investigated [6].

Anatomical context of Griseolic acid A

• Effects of the new phosphodiesterase inhibitor griseolic acid on insulin release in rat pancreatic islets [7].

References