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Gene Review

Cnp  -  2',3'-cyclic nucleotide 3' phosphodiesterase

Rattus norvegicus

Synonyms: 2',3'-cyclic-nucleotide 3'-phosphodiesterase, CNP, CNPF, CNPI, CNPII, ...
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Disease relevance of Cnp1

  • Biochemical properties of cyclic nucleotide phosphodiesterase in metastasizing and nonmetastasizing rat mammary carcinomas [1].
  • Analysis of cyclic nucleotide phosphodiesterase (PDE) activity in cellular fractions from cultured rat pheochromocytoma (PC12) cells has shown that the predominant hydrolytic activity in both cytosolic and particulate compartments is characteristic of a PDE II, the cGMP-activatable family of PDE isozymes [2].
  • After removal of mitogens and addition of thyroid hormone, Rb stopped being expressed and CNPase expression was activated with a temporal course similar to that of oligodendrocytes infected with a control adenovirus [3].
  • The relationship between cell density and the activity of 2':3'-cyclic nucleotide 3'-phosphohydrolase (CNP), an enzyme believed to be specific to oligodendroglial cells and myelin in the brain, has been studied in cultured C-6 glioma cells [4].
  • CONCLUSIONS: In conclusion, this study shows that the natriuretic response to pharmacological doses of CNP and BNP is blunted in rats with cirrhosis [5].

Psychiatry related information on Cnp1


High impact information on Cnp1


Chemical compound and disease context of Cnp1


Biological context of Cnp1


Anatomical context of Cnp1


Associations of Cnp1 with chemical compounds


Physical interactions of Cnp1


Co-localisations of Cnp1


Regulatory relationships of Cnp1


Other interactions of Cnp1


Analytical, diagnostic and therapeutic context of Cnp1


  1. Biochemical properties of cyclic nucleotide phosphodiesterase in metastasizing and nonmetastasizing rat mammary carcinomas. Chatterjee, S.K., Kim, U. J. Natl. Cancer Inst. (1976) [Pubmed]
  2. Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells. Whalin, M.E., Scammell, J.G., Strada, S.J., Thompson, W.J. Mol. Pharmacol. (1991) [Pubmed]
  3. Down-regulation of the retinoblastoma protein (rb) is associated with rat oligodendrocyte differentiation. Huang, Z., Tang, X.M., Cambi, F. Mol. Cell. Neurosci. (2002) [Pubmed]
  4. Induction of an oligodendroglial enzyme in C-6 glioma cells maintained at high density or in serum-free medium. Maltese, W.A., Volpe, J.J. J. Cell. Physiol. (1979) [Pubmed]
  5. Blunted natriuresis and abnormal systemic hemodynamic responses to C-type and brain natriuretic peptides in rats with cirrhosis. Komeichi, H., Moreau, R., Cailmail, S., Gaudin, C., Lebrec, D. J. Hepatol. (1995) [Pubmed]
  6. Administration of ACTH to suckling rats results in hyperkinetic behavior. Izumi, T., Fukuyama, Y., Nomoto, T., Kato, N. Brain Dev. (1986) [Pubmed]
  7. Differential changes in the expression of cyclic nucleotide phosphodiesterase isoforms in rat brains by chronic treatment with electroconvulsive shock. Cho, C.H., Cho, D.H., Seo, M.R., Juhnn, Y.S. Exp. Mol. Med. (2000) [Pubmed]
  8. Diurnal rhythm in rat pineal cyclic nucleotide phosphodiesterase activity. Minneman, K.P., Iversen, L.L. Nature (1976) [Pubmed]
  9. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. Zhao, A.Z., Bornfeldt, K.E., Beavo, J.A. J. Clin. Invest. (1998) [Pubmed]
  10. Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype. Rybalkin, S.D., Bornfeldt, K.E., Sonnenburg, W.K., Rybalkina, I.G., Kwak, K.S., Hanson, K., Krebs, E.G., Beavo, J.A. J. Clin. Invest. (1997) [Pubmed]
  11. cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes. Rivet-Bastide, M., Vandecasteele, G., Hatem, S., Verde, I., Bénardeau, A., Mercadier, J.J., Fischmeister, R. J. Clin. Invest. (1997) [Pubmed]
  12. Inhibitors of cyclic nucleotide phosphodiesterase isozymes type-III and type-IV suppress mitogenesis of rat mesangial cells. Matousovic, K., Grande, J.P., Chini, C.C., Chini, E.N., Dousa, T.P. J. Clin. Invest. (1995) [Pubmed]
  13. Antihypertrophic actions of the natriuretic peptides in adult rat cardiomyocytes: importance of cyclic GMP. Rosenkranz, A.C., Woods, R.L., Dusting, G.J., Ritchie, R.H. Cardiovasc. Res. (2003) [Pubmed]
  14. Cyclic AMP induction of the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphohydrolase in rat oligodendrocytes. McMorris, F.A. J. Neurochem. (1983) [Pubmed]
  15. The involvement of cyclic GMP in tyrosine aminotransferase degradation in rat hepatoma tissue culture cells. Strindent, S.T., Stellwagen, R.H. J. Cell. Physiol. (1981) [Pubmed]
  16. Suppression of arterial intimal hyperplasia by cilostamide, a cyclic nucleotide phosphodiesterase 3 inhibitor, in a rat balloon double-injury model. Inoue, Y., Toga, K., Sudo, T., Tachibana, K., Tochizawa, S., Kimura, Y., Yoshida, Y., Hidaka, H. Br. J. Pharmacol. (2000) [Pubmed]
  17. Assignment of the 1H, 13C and 15N resonances of the catalytic domain of the rat 2',3'-cyclic nucleotide 3'-phosphodiesterase. Kozlov, G., Lee, J., Gravel, M., Ekiel, I., Braun, P.E., Gehring, K. J. Biomol. NMR (2002) [Pubmed]
  18. Juxtanodin: an oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking. Zhang, B., Cao, Q., Guo, A., Chu, H., Chan, Y.G., Buschdorf, J.P., Low, B.C., Ling, E.A., Liang, F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  19. Subcellular localization of cyclic nucleotide phosphodiesterase type 10A variants, and alteration of the localization by cAMP-dependent protein kinase-dependent phosphorylation. Kotera, J., Sasaki, T., Kobayashi, T., Fujishige, K., Yamashita, Y., Omori, K. J. Biol. Chem. (2004) [Pubmed]
  20. Induction of hepatic tyrosine aminotransferase in vivo by derivatives of cyclic adenosine 3':5'-monophosphate. Miller, J.P., Beck, A.H., Simon, L.N., Meyer, R.B. J. Biol. Chem. (1975) [Pubmed]
  21. Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C. Graff, J.M., Young, T.N., Johnson, J.D., Blackshear, P.J. J. Biol. Chem. (1989) [Pubmed]
  22. Expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in the developing olfactory bulb and subventricular zone rostral extension. Gomes, S.S., Carvalho, S.L., Santiago, M.F., Lopez, L.B., Barradas, P.C., Cavalcante, L.A. J. Neurosci. Res. (2003) [Pubmed]
  23. CNPase activity in myelin from adult rat brains after prolonged lead exposure in vivo. Dabrowska-Bouta, B., Sulkowski, G., Struzyńska, L., Rafałowska, U. Chem. Biol. Interact. (2004) [Pubmed]
  24. Nonspecific association of 2',3'-cyclic nucleotide 3'-phosphodiesterase with the rat forebrain postsynaptic density fraction. Cho, S.J., Jung, J.S., Shin, S.C., Jin, I., Ko, B.H., Kim Kwon, Y., Suh-Kim, H., Moon, I.S. Exp. Mol. Med. (2003) [Pubmed]
  25. Inflammatory-mediated model of cerebral palsy with developmental sequelae. Toso, L., Poggi, S., Park, J., Einat, H., Roberson, R., Dunlap, V., Woodard, J., Abebe, D., Spong, C.Y. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  26. Evidence that parathyroid hormone-mediated calcium transport in rat brain synaptosomes is independent of cyclic adenosine monophosphate. Fraser, C.L., Sarnacki, P., Budayr, A. J. Clin. Invest. (1988) [Pubmed]
  27. Hormonally induced cell shape changes in cultured rat ovarian granulosa cells. Lawrence, T.S., Ginzberg, R.D., Gilula, N.B., Beers, W.H. J. Cell Biol. (1979) [Pubmed]
  28. Cyclic adenosine 3':5'-monophosphate and cytosolic calcium exert opposing effects on biosynthesis of tetrodotoxin-sensitive sodium channels in rat muscle cells. Sherman, S.J., Chrivia, J., Catterall, W.A. J. Neurosci. (1985) [Pubmed]
  29. Aberrant cyclic adenosine 3':5'-monophosphate metabolism in cultures of tumorigenic rat urothelium. Chlapowski, F.J., Nemecek, G.M. Cancer Res. (1985) [Pubmed]
  30. Detection of a calmodulin-sensitive cyclic nucleotide phosphodiesterase in rat parotid gland. Ku, K.Y., Butcher, F.R. Biochim. Biophys. Acta (1980) [Pubmed]
  31. Effects of insulin and insulin-like growth factor (IGF-I) on oligodendrocyte-enriched glial cultures. van der Pal, R.H., Koper, J.W., van Golde, L.M., Lopes-Cardozo, M. J. Neurosci. Res. (1988) [Pubmed]
  32. 2',3'-cyclic nucleotide 3'-phosphohydrolase activity in rat visual pathways with experimental allergic encephalomyelitis. Matsushima, S., Machi, N., Marumo, M., Mizuno, A. Jpn. J. Ophthalmol. (1986) [Pubmed]
  33. Posttranslational modulation of glucocorticoid feedback inhibition at the pituitary level. Lim, M.C., Shipston, M.J., Antoni, F.A. Endocrinology (2002) [Pubmed]
  34. Molecular mechanisms involved in the actions of apotransferrin upon the central nervous system: Role of the cytoskeleton and of second messengers. Marta, C.B., Davio, C., Pasquini, L.A., Soto, E.F., Pasquini, J.M. J. Neurosci. Res. (2002) [Pubmed]
  35. Effects of hepatocyte growth factor on cyclic nucleotide-dependent signaling and steroidogenesis in rat ovarian granulosa cells in vitro. Zachow, R.J., Woolery, J.K. Biol. Reprod. (2002) [Pubmed]
  36. Molecular cloning and characterization of rat brain 2',3'-cyclic nucleotide 3'-phosphodiesterase isoform 2. Gravel, M., DeAngelis, D., Braun, P.E. J. Neurosci. Res. (1994) [Pubmed]
  37. Embryonic expression of myelin genes: evidence for a focal source of oligodendrocyte precursors in the ventricular zone of the neural tube. Yu, W.P., Collarini, E.J., Pringle, N.P., Richardson, W.D. Neuron (1994) [Pubmed]
  38. Cellular distribution of phosphodiesterase isoforms in rat cardiac tissue. Bode, D.C., Kanter, J.R., Brunton, L.L. Circ. Res. (1991) [Pubmed]
  39. Myelin formation in rotation-mediated aggregating cell cultures: immunocytochemical, electron microscopic, and biochemical observations. Trapp, B.D., Webster, H.D., Johnson, D., Quarles, R.H., Cohen, S.R., Murray, M.R. J. Neurosci. (1982) [Pubmed]
  40. Peptide mapping of multiple forms of cyclic nucleotide phosphodiesterase. Takemoto, D.J., Hansen, J., Takemoto, L.J., Houslay, M.D. J. Biol. Chem. (1982) [Pubmed]
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