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Chemical Compound Review

PubChem13296     7-ethoxy-4- (trifluoromethyl)chromen-2- one

Synonyms: Etfc cpd, ACMC-1C8TY, CBMicro_044809, AG-D-36502, T2803_SIGMA, ...
 
 
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References

  1. Examination of purported probes of human CYP2B6. Ekins, S., VandenBranden, M., Ring, B.J., Wrighton, S.A. Pharmacogenetics (1997) [Pubmed]
  2. Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling. Spatzenegger, M., Liu, H., Wang, Q., Debarber, A., Koop, D.R., Halpert, J.R. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  3. Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling. Domanski, T.L., Schultz, K.M., Roussel, F., Stevens, J.C., Halpert, J.R. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  4. Functional characterization of cytochrome P450 2B6 allelic variants. Jinno, H., Tanaka-Kagawa, T., Ohno, A., Makino, Y., Matsushima, E., Hanioka, N., Ando, M. Drug Metab. Dispos. (2003) [Pubmed]
  5. Combined three-dimensional quantitative structure-activity relationship analysis of cytochrome P450 2B6 substrates and protein homology modeling. Wang, Q., Halpert, J.R. Drug Metab. Dispos. (2002) [Pubmed]
  6. A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Direct fluorescence monitoring of the deethylation of 7-ethoxy-4-trifluoromethylcoumarin. Buters, J.T., Schiller, C.D., Chou, R.C. Biochem. Pharmacol. (1993) [Pubmed]
  7. Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: substrate specificity with model substrates and promutagens. Penman, B.W., Chen, L., Gelboin, H.V., Gonzalez, F.J., Crespi, C.L. Carcinogenesis (1994) [Pubmed]
  8. A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function. Scott, E.E., Spatzenegger, M., Halpert, J.R. Arch. Biochem. Biophys. (2001) [Pubmed]
  9. High-performance liquid chromatographic method for measurement of cytochrome P450-mediated metabolism of 7-ethoxy-4-trifluoromethylcoumarin. Morse, M.A., Lu, J. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]
 
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