Chemical Compound Review:
Cpodpmb 3-cyclopentyloxy-N-(3,5- dichloropyridin-4...
Synonyms:
Piclamilast, CHEMBL42126, SureCN26573, CCRIS 8304, CHEBI:47619, ...
- Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways. Parrella, E., Gianni', M., Cecconi, V., Nigro, E., Barzago, M.M., Rambaldi, A., Rochette-Egly, C., Terao, M., Garattini, E. J. Biol. Chem. (2004)
- Effects of the phosphodiesterase 4 inhibitor RPR 73401 in a model of immunological inflammation. Ehinger, A.M., Gorr, G., Hoppmann, J., Telser, E., Ehinger, B., Kietzmann, M. Eur. J. Pharmacol. (2000)
- Inhibition of phosphodiesterase activity, airway inflammation and hyperresponsiveness by PDE4 inhibitor and glucocorticoid in a murine model of allergic asthma. Sun, J.G., Deng, Y.M., Wu, X., Tang, H.F., Deng, J.F., Chen, J.Q., Yang, S.Y., Xie, Q.M. Life Sci. (2006)
- Toxicologic and carcinogenic effects of the type IV phosphodiesterase inhibitor RP 73401 on the nasal olfactory tissue in rats. Pino, M.V., Valerio, M.G., Miller, G.K., Larson, J.L., Rosolia, D.L., Jayyosi, Z., Crouch, C.N., Trojanowski, J.Q., Geiger, L.E. Toxicologic pathology. (1999)
- Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram. Zhao, Y., Zhang, H.T., O'Donnell, J.M. J. Pharmacol. Exp. Ther. (2003)
- The selective phosphodiesterase 4 inhibitor RP 73-401 reduced matrix metalloproteinase 9 activity and transforming growth factor-beta release during acute lung injury in mice: the role of the balance between Tumor necrosis factor-alpha and interleukin-10. Corbel, M., Germain, N., Lanchou, J., Molet, S., R e Silva, P.M., Martins, M.A., Boichot, E., Lagente, V. J. Pharmacol. Exp. Ther. (2002)
- Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer. Souness, J.E., Griffin, M., Maslen, C., Ebsworth, K., Scott, L.C., Pollock, K., Palfreyman, M.N., Karlsson, J.A. Br. J. Pharmacol. (1996)
- Human liver CYP2B6-catalyzed hydroxylation of RP 73401. Stevens, J.C., White, R.B., Hsu, S.H., Martinet, M. J. Pharmacol. Exp. Ther. (1997)
- Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling. Domanski, T.L., Schultz, K.M., Roussel, F., Stevens, J.C., Halpert, J.R. J. Pharmacol. Exp. Ther. (1999)
- Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor. Raeburn, D., Underwood, S.L., Lewis, S.A., Woodman, V.R., Battram, C.H., Tomkinson, A., Sharma, S., Jordan, R., Souness, J.E., Webber, S.E. Br. J. Pharmacol. (1994)
- Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors. Saldou, N., Obernolte, R., Huber, A., Baecker, P.A., Wilhelm, R., Alvarez, R., Li, B., Xia, L., Callan, O., Su, C., Jarnagin, K., Shelton, E.R. Cell. Signal. (1998)
- Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP-specific phosphodiesterase: comparison with rolipram. Souness, J.E., Maslen, C., Webber, S., Foster, M., Raeburn, D., Palfreyman, M.N., Ashton, M.J., Karlsson, J.A. Br. J. Pharmacol. (1995)
- Anti-inflammatory activities of a new series of selective phosphodiesterase 4 inhibitors derived from 9-benzyladenine. Boichot, E., Wallace, J.L., Germain, N., Corbel, M., Lugnier, C., Lagente, V., Bourguignon, J.J. J. Pharmacol. Exp. Ther. (2000)
- Modulation of eotaxin formation and eosinophil migration by selective inhibitors of phosphodiesterase type 4 isoenzyme. Silva, P.M., Alves, A.C., Serra, M.F., Pires, A.L., Silva, J.P., Barreto, E.O., Cordeiro, R.S., Jose, P.J., Teixeira, M.M., Lagente, V., Martins, M.A. Br. J. Pharmacol. (2001)
- Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin-2 release from murine splenocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer. Souness, J.E., Houghton, C., Sardar, N., Withnall, M.T. Br. J. Pharmacol. (1997)
- Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol. Au, B.T., Teixeira, M.M., Collins, P.D., Williams, T.J. Br. J. Pharmacol. (1998)
- Suppression of anti-CD3-induced interleukin-4 and interleukin-5 release from splenocytes of Mesocestoides corti-infected BALB/c mice by phosphodiesterase 4 inhibitors. Souness, J.E., Houghton, C., Sardar, N., Withnall, M.T. Biochem. Pharmacol. (1999)
- Effect of food and gender on the pharmacokinetics of RP 73401, a phosphodiesterase IV inhibitor. Argenti, D., Vaccaro, S.K., Shah, B., Gillen, n.u.l.l., Rohatagi, S., Jensen, B.K. International journal of clinical pharmacology and therapeutics. (2000)