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Chemical Compound Review

Lopac-S-003     1-naphthalen-1-ylpiperazine

Synonyms: CHEMBL277120, SureCN240244, SureCN3166780, CHEBI:121432, CCG-205255, ...
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  • The enhancing effect of non-selective serotonergic autoreceptor antagonists, methiothepin (100 microM) or 1-(1-naphthyl)piperazine (NP) (10 microM), administered through the microdialysis probe, after 24 h washout, was similar in both control and chronically treated groups [10].


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  4. Further evidence that the guinea pig tracheal contractile serotonergic receptor is a 5-hydroxytryptamine2 receptor: use of 5-methyltryptamine and dipropyl-5-carboxamidotryptamine. Watts, S.W., Cohen, M.L. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
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  7. Serotonin-antagonist effects of 1-(1-naphthyl)piperazine on operant behavior of squirrel monkeys. McKearney, J.W. Neuropharmacology (1989) [Pubmed]
  8. Serotonergic agonists inhibit calcium-activated potassium and voltage-dependent sodium currents in rat taste receptor cells. Herness, M.S., Chen, Y. J. Membr. Biol. (2000) [Pubmed]
  9. 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Lee, M., Rangisetty, J.B., Pullagurla, M.R., Dukat, M., Setola, V., Roth, B.L., Glennon, R.A. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  10. Effects of acute and repeated administration of citalopram on extracellular levels of serotonin in rat brain. Moret, C., Briley, M. Eur. J. Pharmacol. (1996) [Pubmed]
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