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Chemical Compound Review

Lopac-S-003     1-naphthalen-1-ylpiperazine

Synonyms: CHEMBL277120, SureCN240244, SureCN3166780, CHEBI:121432, CCG-205255, ...
 
 
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High impact information on Lopac-S-003

 

Anatomical context of Lopac-S-003

 

Associations of Lopac-S-003 with other chemical compounds

 

Gene context of Lopac-S-003

 

Analytical, diagnostic and therapeutic context of Lopac-S-003

  • The enhancing effect of non-selective serotonergic autoreceptor antagonists, methiothepin (100 microM) or 1-(1-naphthyl)piperazine (NP) (10 microM), administered through the microdialysis probe, after 24 h washout, was similar in both control and chronically treated groups [10].

References

  1. Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats. Cohen, M.L., Fuller, R.W., Kurz, K.D. Hypertension (1983) [Pubmed]
  2. 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. Jorand-Lebrun, C., Pauwels, P.J., Palmier, C., Moret, C., Chopin, P., Perez, M., Marien, M., Halazy, S. J. Med. Chem. (1997) [Pubmed]
  3. 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. Glennon, R.A., Slusher, R.M., Lyon, R.A., Titeler, M., McKenney, J.D. J. Med. Chem. (1986) [Pubmed]
  4. Further evidence that the guinea pig tracheal contractile serotonergic receptor is a 5-hydroxytryptamine2 receptor: use of 5-methyltryptamine and dipropyl-5-carboxamidotryptamine. Watts, S.W., Cohen, M.L. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  5. Role of 5-HT2 receptors in serotonin-induced contractions of nonvascular smooth muscle. Cohen, M.L., Schenck, K.W., Colbert, W., Wittenauer, L. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  6. Serotonin-induced contraction in canine coronary artery and saphenous vein: role of a 5-HT1D-like receptor. Cushing, D.J., Baez, M., Kursar, J.D., Schenck, K., Cohen, M.L. Life Sci. (1994) [Pubmed]
  7. Serotonin-antagonist effects of 1-(1-naphthyl)piperazine on operant behavior of squirrel monkeys. McKearney, J.W. Neuropharmacology (1989) [Pubmed]
  8. Serotonergic agonists inhibit calcium-activated potassium and voltage-dependent sodium currents in rat taste receptor cells. Herness, M.S., Chen, Y. J. Membr. Biol. (2000) [Pubmed]
  9. 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Lee, M., Rangisetty, J.B., Pullagurla, M.R., Dukat, M., Setola, V., Roth, B.L., Glennon, R.A. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  10. Effects of acute and repeated administration of citalopram on extracellular levels of serotonin in rat brain. Moret, C., Briley, M. Eur. J. Pharmacol. (1996) [Pubmed]
 
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