High impact information on oxonickel

• Insoluble nickel subsulfide and nickel oxide (NiO) are carcinogenic in animals by inhalation; soluble nickel sulfate is not [1].
• Human peripheral lymphocytes from whole blood cultures were exposed to either soluble form of nickel carbonate hydroxide (NiCH) (0-60 muM), or of nickel subsulfide (Ni(3)S(2)) (0-120 muM), or of nickel oxide (NiO) (0-120 muM), or nickel sulfate (NiSO(4)) (0-120 muM) for a short duration of 2 h [2].
• Nickel subsulfide (Ni3S2) and nickel oxide (NiO) penetrated into cells and were concentrated in vacuoles, exhibiting a particular affinity for membrane structure [3].
• In the B6 strain, exposure to nickel oxide (NiO) by instillation (40 to 1000 nm) or inhalation (50 nm) produced no changes, whereas inhalation of NiSO4 (60 or 250 nm) increased lavage proteins and neutrophils [4].
• To evaluate the effect of green nickel oxide (NiO) on the production of tumor necrosis factor (TNF) by alveolar macrophages, alveolar macrophages were exposed to NiO in vitro and in vivo [5].

Biological context of oxonickel

• To investigate the pathogenicity of nickel oxide (NiO), hamsters received life-span exposures to that compound (approximately 55 mg/m3) seven hours per day, five days per week [6].
• Alveolar macrophages recovered from rats exposed to nickel oxide (NiO) showed distinct changes in cell size and presence of viscous substances surrounding the cells [7].

Associations of oxonickel with other chemical compounds

• Insoluble nickel subsulfide (Ni3S2) and nickel oxide (NiO) are carcinogenic to rodents by inhalation [8].

Analytical, diagnostic and therapeutic context of oxonickel

• Spin trapping experiments have been carried out on solutions generated by the dissolution of nickel oxides, all of which contained NiO (bunsenite) as the predominant crystalline phase [9].

References