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Chemical Compound Review

NiSO4     nickel(+2) cation sulfate

Synonyms: ACMC-1CIBU, CCRIS 3732, LS-344, NCI-C60344, NICKEL SULFATE, ...
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High impact information on NICKEL SULFATE HEXAHYDRATE

  • Moreover, treatment of HRRT cells with a nontransforming dose of urethan (1 mM) for 1 hr followed by continuous exposure to nickel sulfate (40 microM) also increased cell survival in the aggregate form [6].
  • Several other agents were investigated with this approach, and no SSB were detected with nickel sulfate, 12-O-tetradecanoylphorbol-13-acetate or asbestos fibers in the presence of the polymerase inhibitor [7].
  • Transient exposure to soluble nickel sulfate failed to increase IL-8 mRNA [8].
  • Only 20% of unstimulated T cells but >40% of nickel-stimulated T cells derived from peripheral blood of the same individuals expressed these V beta elements, suggesting a selection of certain TCR-V beta elements by nickel sulfate in these patients [9].
  • Antioxidant protection from solar-simulated radiation-induced suppression of contact hypersensitivity to the recall antigen nickel sulfate in human skin [3].

Chemical compound and disease context of NICKEL SULFATE HEXAHYDRATE






Associations of NICKEL SULFATE HEXAHYDRATE with other chemical compounds



  • Exposure to nickel sulfate and SDS was investigated in more detail: similar to chemokine secretion, no difference was observed in the time- and concentration-dependent increase in pro-inflammatory cytokine [interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha)] secretion [26].
  • Therefore, IL-4 regulation was investigated in short-term cultured human T cells primed in vitro with either a superantigen or a hapten, nickel sulfate (NiSO4), for 3 days and expanded with IL-2 for another 5 days [27].
  • Maximal increase in IL-1alpha secretion occurred within 2 h after exposure to both nickel sulfate and SDS and prior to increased chemokine secretion [26].
  • E-selectin and VCAM-1 were not expressed on untreated HUVEC; 4 to 6 hours exposure to nickel sulfate and LPS resulted in a potent induction of E-selectin and VCAM-1 expression [28].
  • At 3 days after nickel sulfate, beta-endorphin, 10(-6)-10(-12) M, somatostatin, 10(-7)-10(-9) M and SP, 10(-7)-10(-11) M, gave an enhancement of the response [29].

Analytical, diagnostic and therapeutic context of NICKEL SULFATE HEXAHYDRATE


  1. Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin. Stege, H., Roza, L., Vink, A.A., Grewe, M., Ruzicka, T., Grether-Beck, S., Krutmann, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Comparative carcinogenic effects of nickel subsulfide, nickel oxide, or nickel sulfate hexahydrate chronic exposures in the lung. Dunnick, J.K., Elwell, M.R., Radovsky, A.E., Benson, J.M., Hahn, F.F., Nikula, K.J., Barr, E.B., Hobbs, C.H. Cancer Res. (1995) [Pubmed]
  3. Antioxidant protection from solar-simulated radiation-induced suppression of contact hypersensitivity to the recall antigen nickel sulfate in human skin. Fuchs, J., Packer, L. Free Radic. Biol. Med. (1999) [Pubmed]
  4. Quantitative trait analysis of nickel-induced acute lung injury in mice. Prows, D.R., Leikauf, G.D. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  5. Transformation of immortal, non-tumorigenic osteoblast-like human osteosarcoma cells to the tumorigenic phenotype by nickel sulfate. Rani, A.S., Qu, D.Q., Sidhu, M.K., Panagakos, F., Shah, V., Klein, K.M., Brown, N., Pathak, S., Kumar, S. Carcinogenesis (1993) [Pubmed]
  6. Assay for initiators and promoters of carcinogenesis based on attachment-independent survival of cells in aggregates. Eker, P., Sanner, T. Cancer Res. (1983) [Pubmed]
  7. Detection of DNA single-strand breaks produced during the repair of damage by DNA-protein cross-linking agents. Fornace, A.J. Cancer Res. (1982) [Pubmed]
  8. A novel pathway for nickel-induced interleukin-8 expression. Barchowsky, A., Soucy, N.V., O'Hara, K.A., Hwa, J., Noreault, T.L., Andrew, A.S. J. Biol. Chem. (2002) [Pubmed]
  9. Dichotomy of blood- and skin-derived IL-4-producing allergen-specific T cells and restricted V beta repertoire in nickel-mediated contact dermatitis. Werfel, T., Hentschel, M., Kapp, A., Renz, H. J. Immunol. (1997) [Pubmed]
  10. Patch testing of nickel sulfate and potassium dichromate with a standardized ready-to-use test system gives highly reproducible results: a double-blind multicentre study. Brasch, J., Henseler, T., Aberer, W., Fuchs, T., Hoeck, U., Kreilgård, B. Acta Derm. Venereol. (2001) [Pubmed]
  11. Patch test results in 542 patients with suspected contact dermatitis in Turkey. Akasya-Hillenbrand, E., Ozkaya-Bayazit, E. Contact Derm. (2002) [Pubmed]
  12. Tacrolimus ointment in nickel sulphate-induced steroid-resistant allergic contact dermatitis. Pacor, M.L., Di Lorenzo, G., Martinelli, N., Mansueto, P., Friso, S., Pellitteri, M.E., Di Fede, G., Rini, G., Corrocher, R. Allergy and asthma proceedings : the official journal of regional and state allergy societies (2006) [Pubmed]
  13. Association of adrenal pheochromocytoma and lung pathology in inhalation studies with particulate compounds in the male F344 rat--the National Toxicology Program experience. Ozaki, K., Haseman, J.K., Hailey, J.R., Maronpot, R.R., Nyska, A. Toxicologic pathology. (2002) [Pubmed]
  14. Bioavailability of nickel in man: effects of foods and chemically-defined dietary constituents on the absorption of inorganic nickel. Solomons, N.W., Viteri, F., Shuler, T.R., Nielsen, F.H. J. Nutr. (1982) [Pubmed]
  15. Induction of aneuploidy by nickel sulfate in V79 Chinese hamster cells. Ohshima, S. Mutat. Res. (2001) [Pubmed]
  16. Gene expression signatures in CD34+-progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulfate. Schoeters, E., Nuijten, J.M., Van Den Heuvel, R.L., Nelissen, I., Witters, H., Schoeters, G.E., Van Tendeloo, V.F., Berneman, Z.N., Verheyen, G.R. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  17. Allergic contact dermatitis to nickel is associated with a Taq I HLA-DQA allelic restriction fragment. Olerup, O., Emtestam, L. Immunogenetics (1988) [Pubmed]
  18. Mononuclear cell subsets in the nickel-allergic reaction in vitro and in vivo. Silvennoinen-Kassinen, S., Ikäheimo, I., Karvonen, J., Kauppinen, M., Kallioinen, M. J. Allergy Clin. Immunol. (1992) [Pubmed]
  19. Effects of nickel sulfate on growth and differentiation of normal human bronchial epithelial cells. Lechner, J.F., Tokiwa, T., McClendon, I.A., Haugen, A. Carcinogenesis (1984) [Pubmed]
  20. Inhibition of in vitro nickel sulfate reaction by anti-HLA-D/DR antisera. Lack of demonstrable suppressor cells in peripheral blood in nickel unresponsiveness in man. Silvennoinen-Kassinen, S., Ilonen, J., Tiilikainen, A., Karvonen, J. J. Invest. Dermatol. (1981) [Pubmed]
  21. Lack of micronuclei formation in bone marrow of rats after repeated oral exposure to nickel sulfate hexahydrate. Oller, A.R., Erexson, G. Mutat. Res. (2007) [Pubmed]
  22. Nickel compound-induced DNA single-strand breaks in chromosomal and nuclear chromatin in human blood lymphocytes in vitro: role of oxidative stress and intracellular calcium. M'Bemba-Meka, P., Lemieux, N., Chakrabarti, S.K. Mutat. Res. (2005) [Pubmed]
  23. Allergic patch test reactions to palladium chloride in schoolchildren. Kanerva, L., Kerosuo, H., Kullaa, A., Kerosuo, E. Contact Derm. (1996) [Pubmed]
  24. European Standard Series patch test results from a contact dermatitis clinic in Israel during the 7-year period from 1998 to 2004. Lazarov, A. Contact Derm. (2006) [Pubmed]
  25. Long-lasting allergic patch test reactions: a study of patients with positive standard patch tests. Mancuso, G., Berdondini, R.M., Cavrini, G. Contact Derm. (1999) [Pubmed]
  26. Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure. Spiekstra, S.W., Toebak, M.J., Sampat-Sardjoepersad, S., van Beek, P.J., Boorsma, D.M., Stoof, T.J., von Blomberg, B.M., Scheper, R.J., Bruynzeel, D.P., Rustemeyer, T., Gibbs, S. Exp. Dermatol. (2005) [Pubmed]
  27. A strict requirement of interleukin-4 for interleukin-4 induction in antigen-stimulated human memory T cells. Breit, S., Steinhoff, M., Blaser, K., Heusser, C.H., Sebald, W., Levine, A.D., Röcken, M. Eur. J. Immunol. (1996) [Pubmed]
  28. Increased expression of ICAM-1, E-selectin, and VCAM-1 by cultured human endothelial cells upon exposure to haptens. Wildner, O., Lipkow, T., Knop, J. Exp. Dermatol. (1992) [Pubmed]
  29. Modulating effect of beta-endorphin, somatostatin, substance P and vasoactive intestinal peptide on the proliferative response of peripheral blood T lymphocytes of nickel-allergic patients to nickel sulfate. Nordlind, K., Mutt, V. Int. Arch. Allergy Appl. Immunol. (1986) [Pubmed]
  30. Analysis of effector and regulatory immune reactivity to nickel. Rustemeyer, T., von Blomberg, B.M., van Hoogstraten, I.M., Bruynzeel, D.P., Scheper, R.J. Clin. Exp. Allergy (2004) [Pubmed]
  31. Effect of nickel sulfate on testicular steroidogenesis in rats during protein restriction. Das, K.K., Dasgupta, S. Environ. Health Perspect. (2002) [Pubmed]
  32. Contact sensitizer nickel sulfate activates the transcription factors NF-kB and AP-1 and increases the expression of nitric oxide synthase in a skin dendritic cell line. Cruz, M.T., Gonçalo, M., Figueiredo, A., Carvalho, A.P., Duarte, C.B., Lopes, M.C. Exp. Dermatol. (2004) [Pubmed]
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