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Chemical Compound Review

AC1NSEJJ     nickel; sulfane

Synonyms: CTK0I3613
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Disease relevance of TRINICKEL DISULFIDE


Psychiatry related information on TRINICKEL DISULFIDE


High impact information on TRINICKEL DISULFIDE


Chemical compound and disease context of TRINICKEL DISULFIDE


Biological context of TRINICKEL DISULFIDE


Anatomical context of TRINICKEL DISULFIDE

  • The carcinogenicity of nickel subsulfide, Ni3S2, for respiratory tract epithelium was studied in heterotopic tracheal transplants with doses of 1 and 3 mg Ni3S2 per trachea [21].
  • Carcinogenicity of nickel subsulfide for respiratory tract mucosa [21].
  • Nickel subsulfide in moderate doses caused morphological transformation to type I, II, and III foci and induced long microvilli on the cells in the transformed cultures, demonstrating oncogenic transforming ability [18].
  • Nickel subsulfide (Ni3S2) was injected in various amounts into the testis of adult Fischer rats for the study of the acute and chronic effects of Ni3S2 on testicular cells [22].
  • Nickel subsulfide, alpha Ni3S2, was a notable exception to the general concordance between phagocytic indices and dissolution half-times: alpha Ni3S2 was avidly phagocytized by macrophages, yet it had one or the shortest dissolution half-times [23].

Associations of TRINICKEL DISULFIDE with other chemical compounds




Analytical, diagnostic and therapeutic context of TRINICKEL DISULFIDE


  1. Inhibition of rat natural killer cell function by carcinogenic nickel compounds: preventive action of manganese. Judde, J.G., Breillout, F., Clemenceau, C., Poupon, M.F., Jasmin, C. J. Natl. Cancer Inst. (1987) [Pubmed]
  2. Fate of nickel subsulfide during carcinogenesis studied by autoradiography and X-ray powder diffraction. Oskarsson, A., Andersson, Y., Tjälve, H. Cancer Res. (1979) [Pubmed]
  3. A novel pathway for nickel-induced interleukin-8 expression. Barchowsky, A., Soucy, N.V., O'Hara, K.A., Hwa, J., Noreault, T.L., Andrew, A.S. J. Biol. Chem. (2002) [Pubmed]
  4. Renal carcinomas and erythrocytosis in rats following intrarenal injection of nickel subsulfide. Jasmin, G., Riopelle, J.L. Lab. Invest. (1976) [Pubmed]
  5. The role of bone fracture at the site of carcinogen exposure on nickel carcinogenesis in the soft tissue. Ohmori, T., Uraga, N., Komi, K., Tabei, R., Shibata, T. Jpn. J. Cancer Res. (1990) [Pubmed]
  6. Dose-response and time-response study of erythrocytosis in rats after intrarenal injection of nickel subsulfide. Morse, E.E., Lee, T.Y., Reiss, R.F., Sunderman, F.W. Ann. Clin. Lab. Sci. (1977) [Pubmed]
  7. Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide. Huang, C., Li, J., Costa, M., Zhang, Z., Leonard, S.S., Castranova, V., Vallyathan, V., Ju, G., Shi, X. Cancer Res. (2001) [Pubmed]
  8. Comparative carcinogenic effects of nickel subsulfide, nickel oxide, or nickel sulfate hexahydrate chronic exposures in the lung. Dunnick, J.K., Elwell, M.R., Radovsky, A.E., Benson, J.M., Hahn, F.F., Nikula, K.J., Barr, E.B., Hobbs, C.H. Cancer Res. (1995) [Pubmed]
  9. Low incidence of point mutations detected in the p53 tumor suppressor gene from chemically induced rat renal mesenchymal tumors. Weghorst, C.M., Dragnev, K.H., Buzard, G.S., Thorne, K.L., Vandeborne, G.F., Vincent, K.A., Rice, J.M. Cancer Res. (1994) [Pubmed]
  10. GGT to GTT transversions in codon 12 of the K-ras oncogene in rat renal sarcomas induced with nickel subsulfide or nickel subsulfide/iron are consistent with oxidative damage to DNA. Higinbotham, K.G., Rice, J.M., Diwan, B.A., Kasprzak, K.S., Reed, C.D., Perantoni, A.O. Cancer Res. (1992) [Pubmed]
  11. Enhancement of hydroxylation and deglycosylation of 2'-deoxyguanosine by carcinogenic nickel compounds. Kasprzak, K.S., Hernandez, L. Cancer Res. (1989) [Pubmed]
  12. Nickel--magnesium interactions in carcinogenesis: dose effects and involvement of natural killer cells. Kasprzak, K.S., Ward, J.M., Poirier, L.A., Reichardt, D.A., Denn, A.C., Reynolds, C.W. Carcinogenesis (1987) [Pubmed]
  13. Comparative toxicity of nickel oxide, nickel sulfate hexahydrate, and nickel subsulfide after 12 days of inhalation exposure to F344/N rats and B6C3F1 mice. Dunnick, J.K., Benson, J.M., Hobbs, C.H., Hahn, F.F., Cheng, Y.S., Eidson, A.F. Toxicology (1988) [Pubmed]
  14. Chelation therapy in nickel poisoning. Sunderman, F.W. Ann. Clin. Lab. Sci. (1981) [Pubmed]
  15. Multiple modes of responses to air pollution particulate materials in A549 alveolar type II cells. Seagrave, J.C., Nikula, K.J. Inhalation toxicology. (2000) [Pubmed]
  16. Manganese inhibition of nickel subsulfide induction of erythrocytosis in rats. Hopfer, S.M., Sunderman, F.W. Res. Commun. Chem. Pathol. Pharmacol. (1978) [Pubmed]
  17. Phagocytosis of nickel subsulfide particles during the early stages of neoplastic transformation in tissue culture. Costa, M., Mollenhauer, H.H. Cancer Res. (1980) [Pubmed]
  18. Oncogenic transformation and cell lysis in C3H/10T 1/2 cells and increased sister chromatid exchange in human lymphocytes by nickel subsulfide. Saxholm, H.J., Reith, A., Brøgger, A. Cancer Res. (1981) [Pubmed]
  19. Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides. Kawanishi, S., Oikawa, S., Inoue, S., Nishino, K. Environ. Health Perspect. (2002) [Pubmed]
  20. Magnesium inhibits nickel-induced genotoxicity and formation of reactive oxygen. Hong, Y.C., Paik, S.R., Lee, H.J., Lee, K.H., Jang, S.M. Environ. Health Perspect. (1997) [Pubmed]
  21. Carcinogenicity of nickel subsulfide for respiratory tract mucosa. Yarita, T., Nettesheim, P. Cancer Res. (1978) [Pubmed]
  22. Induction of testicular sarcomas in Fischer rats by intratesticular injection of nickel subsulfide. Damjanov, I., Sunderman, F.W., Mitchell, J.M., Allpass, P.R. Cancer Res. (1978) [Pubmed]
  23. Phagocytosis of particulate nickel compounds by rat peritoneal macrophages in vitro. Kuehn, K., Fraser, C.B., Sunderman, F.W. Carcinogenesis (1982) [Pubmed]
  24. Non-cancer risk assessment for nickel compounds: issues associated with dose-response modeling of inhalation and oral exposures. Haber, L.T., Allen, B.C., Kimmel, C.A. Toxicol. Sci. (1998) [Pubmed]
  25. DNA-protein crosslinks induced by nickel compounds in isolated rat lymphocytes: role of reactive oxygen species and specific amino acids. Chakrabarti, S.K., Bai, C., Subramanian, K.S. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  26. Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds. Miura, T., Patierno, S.R., Sakuramoto, T., Landolph, J.R. Environ. Mol. Mutagen. (1989) [Pubmed]
  27. Metallothionein-I/II double knockout mice are no more sensitive to the carcinogenic effects of nickel subsulfide than wild-type mice. Waalkes, M.P., Liu, J., Kasprzak, K.S., Diwan, B.A. International journal of toxicology. (2005) [Pubmed]
  28. Nickel requires hypoxia-inducible factor-1 alpha, not redox signaling, to induce plasminogen activator inhibitor-1. Andrew, A.S., Klei, L.R., Barchowsky, A. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  29. Nickel-induced plasminogen activator inhibitor-1 expression inhibits the fibrinolytic activity of human airway epithelial cells. Andrew, A., Barchowsky, A. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  30. Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas. Kowara, R., Salnikow, K., Diwan, B.A., Bare, R.M., Waalkes, M.P., Kasprzak, K.S. Mol. Cell. Biochem. (2004) [Pubmed]
  31. Nickel subsulfide is similar to potassium dichromate in protecting normal human fibroblasts from the mutagenic effects of benzo[a]pyrene diolepoxide. Hamdan, S., Morse, B., Reinhold, D. Environ. Mol. Mutagen. (1999) [Pubmed]
  32. Nickel subsulfide is genotoxic in vitro but shows no mutagenic potential in respiratory tract tissues of BigBlue rats and Muta Mouse mice in vivo after inhalation. Mayer, C., Klein, R.G., Wesch, H., Schmezer, P. Mutat. Res. (1998) [Pubmed]
  33. Hazard identification and dose response of inhaled nickel-soluble salts. Haber, L.T., Erdreicht, L., Diamond, G.L., Maier, A.M., Ratney, R., Zhao, Q., Dourson, M.L. Regulatory toxicology and pharmacology : RTP. (2000) [Pubmed]
  34. Minimal influence of metallothionein over-expression on nickel carcinogenesis in mice. Waalkes, M.P., Liu, J., Kasprzak, K.S., Diwan, B.A. Toxicol. Lett. (2004) [Pubmed]
  35. Increased immunoreactive erythropoietin in serum and kidney extracts. Hopfer, S.M., Sunderman, F.W., Reid, M.C., Goldwasser, E. Res. Commun. Chem. Pathol. Pharmacol. (1984) [Pubmed]
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