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Chemical Compound Review

CHEMBL6648     naphthalene-1-sulfonamide

Synonyms: SureCN28464, AG-H-62095, AG-J-12235, ACMC-20gyon, CHEBI:100796, ...
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Disease relevance of Naphthalenesulfonamide


High impact information on Naphthalenesulfonamide


Biological context of Naphthalenesulfonamide

  • Thus, naphthalenesulfonamide PKC inhibitors may include both agents which primarily function by interacting with the phospholipid cofactor of the enzyme and agents which primarily serve as active site inhibitors of PKC [7].

Anatomical context of Naphthalenesulfonamide


Associations of Naphthalenesulfonamide with other chemical compounds


Gene context of Naphthalenesulfonamide


  1. Calmodulin antagonists inhibit human immunodeficiency virus-induced cell fusion but not virus replication. Srinivas, R.V., Bernstein, H., Oliver, C., Compans, R.W. AIDS Res. Hum. Retroviruses (1994) [Pubmed]
  2. Caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors. Xu, Y.W., Zhao, G.S., Shin, C.G., Zang, H.C., Lee, C.K., Lee, Y.S. Bioorg. Med. Chem. (2003) [Pubmed]
  3. Role of calcium and calmodulin in activation of the oxyntic cell by histamine and carbamylcholine in the guinea pig. Walker, W., Vinik, A., Heldsinger, A., Kaveh, R. J. Clin. Invest. (1983) [Pubmed]
  4. Two types of calcium-dependent protein phosphorylations modulated by calmodulin antagonists. Naphthalenesulfonamide derivatives. Tanaka, T., Ohmura, T., Yamakado, T., Hidaka, H. Mol. Pharmacol. (1982) [Pubmed]
  5. Ca2+/calmodulin inhibition and phospholipase C-linked Ca2+ Signaling in clonal beta-cells. Schöfl, C., Mader, T., Krämer, C., Waring, M., Krippeit-Drews, P., Prank, K., von zur Mühlen, A., Drews, G., Brabant, G. Endocrinology (1999) [Pubmed]
  6. Homologous desensitization of serotonin 5-HT2 receptor-stimulated intracellular calcium mobilization in C6BU-1 glioma cells via a mechanism involving a calmodulin pathway. Kagaya, A., Mikuni, M., Muraoka, S., Saitoh, K., Ogawa, T., Shinno, H., Yamawaki, S., Takahashi, K. J. Neurochem. (1993) [Pubmed]
  7. Binding of protein kinase C to N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide through its ATP binding site. O'Brian, C.A., Ward, N.E. Biochem. Pharmacol. (1989) [Pubmed]
  8. N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C. Ito, M., Tanaka, T., Inagaki, M., Nakanishi, K., Hidaka, H. Biochemistry (1986) [Pubmed]
  9. Naphthalenesulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells. Reig, J.A., Viniegra, S., Ballesta, J.J., Palmero, M., Guitierrez, L.M. Neurochem. Res. (1993) [Pubmed]
  10. Mouse hypothalamic somatostatin release: roles of calcium and calmodulin. Richardson, S., Twente, S. Endocrinology (1985) [Pubmed]
  11. Isolation and kinetic characterization of the calmodulin methyltransferase from sheep brain. Han, C.H., Richardson, J., Oh, S.H., Roberts, D.M. Biochemistry (1993) [Pubmed]
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