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Chemical Compound Review

Lopac-A-3281     N-(6-aminohexyl)-5-chloro- naphthalene-1...

Synonyms: Tocris-0369, CHEMBL41631, SureCN166960, BSPBio_001230, BSPBio_003200, ...
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Disease relevance of W 7


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Biological context of W 7


Anatomical context of W 7


Associations of W 7 with other chemical compounds


Gene context of W 7


Analytical, diagnostic and therapeutic context of W 7


  1. Phosphorylation and dephosphorylation events play critical roles in Sindbis virus maturation. Liu, N., Brown, D.T. Virology (1993) [Pubmed]
  2. Inhibition of lung metastasis by a calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), in mice bearing Lewis lung carcinoma. Ito, H., Wang, J.Z., Shimura, K. Anticancer Res. (1991) [Pubmed]
  3. Antitumor effect of a calmodulin antagonist on the growth of solid sarcoma-180. Ito, H., Hidaka, H. Cancer Lett. (1983) [Pubmed]
  4. Establishment of a cisplatin-resistant human ovarian cancer cell line. Kikuchi, Y., Miyauchi, M., Kizawa, I., Oomori, K., Kato, K. J. Natl. Cancer Inst. (1986) [Pubmed]
  5. Circumvention of multiple-drug resistance in human cancer cells by thioridazine, trifluoperazine, and chlorpromazine. Akiyama, S., Shiraishi, N., Kuratomi, Y., Nakagawa, M., Kuwano, M. J. Natl. Cancer Inst. (1986) [Pubmed]
  6. Tamoxifen modulation of cisplatin sensitivity in human malignant melanoma cells. McClay, E.F., Albright, K.D., Jones, J.A., Christen, R.D., Howell, S.B. Cancer Res. (1993) [Pubmed]
  7. Effect of malignant transformation, retinoic acid, trifluoperazine, and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) on the sensitivity of rodent cells to Pseudomonas toxin. Sundan, A., Sandvig, K., Olsnes, S. Cancer Res. (1984) [Pubmed]
  8. Antagonists of calcium fluxes and calmodulin block activation of the p21-activated protein kinases in neutrophils. Lian, J.P., Crossley, L., Zhan, Q., Huang, R., Coffer, P., Toker, A., Robinson, D., Badwey, J.A. J. Immunol. (2001) [Pubmed]
  9. Two types of calcium-dependent protein phosphorylations modulated by calmodulin antagonists. Naphthalenesulfonamide derivatives. Tanaka, T., Ohmura, T., Yamakado, T., Hidaka, H. Mol. Pharmacol. (1982) [Pubmed]
  10. Hydrophobic interaction of the Ca2+-calmodulin complex with calmodulin antagonists. Naphthalenesulfonamide derivatives. Tanaka, T., Ohmura, T., Hidaka, H. Mol. Pharmacol. (1982) [Pubmed]
  11. Effect of calmodulin antagonists on endocytosis and intracellular transport of ricin in polarized MDCK cells. Llorente, A., Garred, O., Holm, P.K., Eker, P., Jacobsen, J., van Deurs, B., Sandvig, K. Exp. Cell Res. (1996) [Pubmed]
  12. Inhibition by calmodulin antagonists of [3H]MK-801 binding in brain synaptic membranes. Ogita, K., Suzuki, T., Pingping, Z., Yoneda, Y. J. Neurochem. (1992) [Pubmed]
  13. Anti-leptin receptor antibody mimics the stimulation of lipolysis induced by leptin in isolated mouse fat pads. Kawaji, N., Yoshida, A., Motoyashiki, T., Morita, T., Ueki, H. J. Lipid Res. (2001) [Pubmed]
  14. Basic protein in brain myelin is phosphorylated by endogenous phospholipid-sensitive Ca2+-dependent protein kinase. Turner, R.S., Chou, C.H., Kibler, R.F., Kuo, J.F. J. Neurochem. (1982) [Pubmed]
  15. nMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase. Chetkovich, D.M., Sweatt, J.D. J. Neurochem. (1993) [Pubmed]
  16. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) stimulation of K+ transport in a human salivary epithelial cell line. Patton, L., Ship, J., Wellner, R. Biochem. Pharmacol. (1991) [Pubmed]
  17. Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine tracheal smooth muscle. Asano, M. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  18. Thrombin-stimulated phosphorylation of myosin light chain and its possible involvement in endothelin-1 secretion from porcine aortic endothelial cells. Kitazumi, K., Tasaka, K. Biochem. Pharmacol. (1992) [Pubmed]
  19. Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway. Etgen, G.J., Fryburg, D.A., Gibbs, E.M. Diabetes (1997) [Pubmed]
  20. Inhibitory actions of calmodulin antagonists on steroidogenesis in zona glomerulosa cells. Wilson, J.X., Aguilera, G., Catt, K.J. Endocrinology (1984) [Pubmed]
  21. Hydrogen peroxide stimulates extracellular signal-regulated protein kinases in pulmonary arterial smooth muscle cells. Zhang, J., Jin, N., Liu, Y., Rhoades, R.A. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
  22. Interaction of the dihydropyridine calcium antagonist, CD-349, with calmodulin. Tanaka, M., Muramatsu, M., Aihara, H., Otomo, S. Biochem. Pharmacol. (1990) [Pubmed]
  23. Inhibition by antipsychotic drugs of L-type Ca2+ channel current in PC12 cells. Ito, K., Nakazawa, K., Koizumi, S., Liu, M., Takeuchi, K., Hashimoto, T., Ohno, Y., Inoue, K. Eur. J. Pharmacol. (1996) [Pubmed]
  24. Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions. Comparison with the role of phosphotidylinositol-3 kinase. Verploegen, S., van Leeuwen, C.M., van Deutekom, H.W., Lammers, J.W., Koenderman, L., Coffer, P.J. Eur. J. Biochem. (2002) [Pubmed]
  25. Calmodulin antagonists increase the expression of membrane-type-1 matrix metalloproteinase in human uterine cervical fibroblasts. Ito, A., Yamada, M., Sato, T., Sanekata, K., Sato, H., Seiki, M., Nagase, H., Mori, Y. Eur. J. Biochem. (1998) [Pubmed]
  26. Inhibitors of IL-2 production and IL-2 receptor expression in human leukemic T-cell line, Jurkat. Koizumi, T., Nakao, Y., Matsui, T., Katakami, Y., Katakami, N., Fujita, T. Cell. Immunol. (1986) [Pubmed]
  27. Calcium/calmodulin-dependent kinase II is involved in the facilitating effect of clozapine on NMDA- and electrically evoked responses in the medial prefrontal cortical pyramidal cells. Ninan, I., Jardemark, K.E., Liang, X., Wang, R.Y. Synapse (2003) [Pubmed]
  28. The adaptor Grb7 is a novel calmodulin-binding protein: functional implications of the interaction of calmodulin with Grb7. Li, H., Sánchez-Torres, J., del Carpio, A.F., Nogales-González, A., Molina-Ortiz, P., Moreno, M.J., Török, K., Villalobo, A. Oncogene (2005) [Pubmed]
  29. Purification and characterization of adipose tissue S-100b protein. Hidaka, H., Endo, T., Kawamoto, S., Yamada, E., Umekawa, H., Tanabe, K., Hara, K. J. Biol. Chem. (1983) [Pubmed]
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