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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Butandiol     butane-1,1-diol

Synonyms: AG-K-60711, ACMC-20cydz, KST-1B2848, CTK1A6558, AR-1B4469, ...
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Disease relevance of butanediol

  • These results suggest that PTBBS provide a useful marker of neuronal damage in a transient forebrain ischemia model and confirm the beneficial effect on ischemic damage exerted by BD [1].
  • Pretreatment with DCA, Man, and BD appears to protect against development of posttraumatic cortical edema when measured 6 hours after blunt head trauma in the rat [2].
  • Maternal ketosis was induced in sows by feeding 20% of the dietary energy as 1,3-butylene glycol (BG), medium-chain triglycerides (MCT), or a combination of the two [3].

High impact information on butanediol

  • The soft segment of these polyurethanes was hydroxylated poly(isoprene) diol and the hard segments were 4,4'-methylenediphenyl diisocyanate (MDI) and 1,4-butanediol (BD) [4].
  • Hence, in this study, an activated human MDM cell system was used to assess the biostability of a PCNU, synthesized with 14C-hexane diisocyanate (HDI) and butanediol (BD), previously shown to be susceptible to hydrolysis by cholesterol esterase (CE) [5].
  • In calves fed the BHBA-inducing diet (BG), an increase in lymphocyte proliferation to BRSV was observed (P < 0.05) [6].
  • Pregnancy rates (Day 90 ultrasound) of recipients that were transferred either two non-vitrified or two vitrified (20% EG+20% DMSO+10% BD) blastocysts, did not differ (3/6 [50%] and 11/20 [55%]) [7].
  • Furthermore, maternal ketosis induced by BG increased fetal brain weight, protein content, and cell size [3].


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