Disease relevance of Dimethylene glycol

• Intraperitoneal injection of 5 mumol of acetone/g, body weight, into 3 rats previously fed 1% acetone (v/v) in their drinking water resulted in the appearance in blood serum of 16 +/- 2 nmol of 1,2-propanediol/ml and 8 +/- 1 nmol of 2,3-butanediol/ml [1].
• CONCLUSIONS: Butanediol biphenylcarboxylic acid derivatives represent a new class of antiresorptive drug that might be of therapeutic value in the prevention and treatment of diseases characterized by osteoclast activation such as osteoporosis, cancer-associated bone disease, and Paget's disease of bone [2].
• Pretreatment with butanediol resulted in significantly better total motor performance among fasted rats 24 hours after ischemia; however, by 48 hours postischemia, no difference was detectable [3].
• Butanediol induced ketosis increases tolerance to hypoxia in the mouse [4].
• Early appearance of 2,3-butanediol in acute myocardial infarction. A new marker for ischaemia [5]?

Psychiatry related information on Dimethylene glycol

• The identification of 2,3-butanediol in sera of alcoholics led to the hypothesis that it may be a specific marker of alcohol abuse [6].

High impact information on Dimethylene glycol

• The disrupted strain could also grow on 2,3-butanediol, although attaining a lesser cell density than the wild-type strain [7].
• We studied whether butanediol treatment altered the adverse consequences following ischemia complicated by hyperglycemia [8].
• We conclude that in pigs' anaerobic myocardia accumulation of 2,3-butanediol occurs; if the myocardium is reperfused this metabolite also appears in the blood [9].
• In the second study, where ischaemia was similarly induced, and where reperfusion was achieved by re-opening the ligated coronary artery after 20 min, 2,3-butanediol in peripheral blood was found to increase significantly [9].
• An ethanol dimer that induces systemic ketosis, 25 mmol/kg i.p. butanediol was injected every 3 hours to produce a sustained increase in the plasma level of beta-hydroxybutyrate [10].

Chemical compound and disease context of Dimethylene glycol

• Our results support the hypothesis that the beneficial effect of butanediol is mediated through cerebral utilization of ketone bodies arising from butanediol metabolism, reducing the rate of glycolysis and the deleterious accumulation of lactic acid during ischemia [10].
• Fermentation product butane 2,3-diol induces Ca(2+) transients in E. coli through activation of lanthanum-sensitive Ca(2+) channels [11].
• Seven Japanese medical students, three "flushers" and four "non-flushers," were given 0.5 g ethanol/kg body weight PO in an attempt to assess whether elevated body acetaldehyde can account for 2,3-butanediol production in humans [12].
• Steers given butanediol plus phlorizin did not show all the usual signs of lactation ketosis, but the treatment still offers promise for studying causes and effects of ketosis [13].
• Besides the characteristics of Vibrionaceae the most typical and differential diagnostic important features were: sucrose fermentation, lysine decarboxylase activity, acetoine and 2,3 butanediol production, no growth on an electrolyte deficient medium (CLED), arginine and arabinose negative reaction [14].

Biological context of Dimethylene glycol

• Anaerobic formation of 2,3-butanediol via acetoin involves acetolactate synthase and decarboxylase encoded by the alsSD operon [15].
• When grown with the 2% casein acid hydrolysate supplement, the strain bearing vgb on plasmid pUC8:15 produced much more acetoin and 2,3-butanediol than the other strains after 26 hours in culture [16].
• 0. Under conditions optimal for 2,3-butanediol synthesis, when aeration limited growth, the rate of biomass growth was more tightly related to the aeration rate in lactose medium than in glucose + galactose medium [17].
• Average pig weights at 28 d of age for litters of sows fed butanediol prepartally were similar to those of sows fed starch, but were less (P less than .01) than those of sows fed lard throughout lactation [18].
• Two constraints were imposed on this preclinical study: The rate of ester administration was limited to one half of the daily caloric requirement and to one half of the capacity of the liver to oxidize butanediol derived from ester hydrolysis [19].

Anatomical context of Dimethylene glycol

• To investigate the role of 2,3-butanediol in myocardial ischaemia we analysed this compound in pig's myocardium and blood [9].
• In the pigs in which the coronary artery was not re-opened, the 2,3-butanediol level in peripheral blood was unchanged [9].
• METHODS: Hyperglycemic adult male rats were given 25 or 50 mmol.kg-1 body wt butanediol intravenously 30 minutes before 10 minutes of transient forebrain ischemia [8].
• Acetaldehyde (0.1 and 0.2 mmol X l-1), 1,2-propanediol (0.8 mmol X l-1) and 2,3-butanediol (0.4 mmol X l-1) inhibited all fractions of 86Rb influx in erythrocytes, but not in leucocytes [20].
• We devised a simple method for determining the cryoprotectant agents 1,4-butanediol or 2,3-butanediol in isolated rat hepatocytes [21].

Associations of Dimethylene glycol with other chemical compounds

• Three metabolites identified for the first time in urine from normal neonates were 2,3-butanediol, 3-hydroxy-2-butanone (acetoin), and 4-hydroxy-3-methoxyphenyllactic acid [22].
• The cyclic phenylboronate ester derivatives of 2,3-butanediol and ethylene glycol had the same retention time when OV-17 was used as the stationary phase for gas chromatography [23].
• The effects of acetaldehyde and 2,3-butanediol on rat embryos developing in vitro [24].
• Culture densities, pH, and diacetyl, acetoin, and 2,3-butanediol levels were recorded [25].
• Moreover, at an initial pH of 6.0, similar amounts of acetoin were obtained, but in addition approximately 20% of the pyruvate was converted into butanediol [26].

Gene context of Dimethylene glycol

• However, the disruption of the YAL060W gene was not lethal for the yeast under laboratory conditions, and the disrupted strain could also grow in 2,3-butanediol and acetoin [27].
• We have investigated the permeability of the human red blood cell to four di-hydroxy alcohols, 1,2PD (1,2 propanediol), 1,3PD (1.3 propanediol), 1,4BD (1,4 butanediol), and 2,3BD (2,3 butanediol), and to water by using a recently developed ESR stopped-flow method which is free from artifacts found in light scattering methods [28].
• The aco genes and adh constitute presumably one single operon which encodes all enzymes required for the conversion of 2,3-butanediol to central metabolites [29].
• Proton nuclear magnetic resonance detects leucine, 2,3-butanediol, and a prominent increase in the level of choline in the sera from patients chronically infected with schistosomiasis japonica [30].

Analytical, diagnostic and therapeutic context of Dimethylene glycol

• Here we show that such molecules can be identified through circular dichroism in core-level photoemission arising from the chiral carbon atoms in stereoisomers of 2,3-butanediol molecules adsorbed on Si(100), using circularly polarized x rays [31].
• The bioconversion of cellulose and hemicellulose substrates to 2,3-butanediol by a sequential coculture approach was investigated with the cellulolytic fungus Trichoderma harzianum E58 and the fermentative bacterium Klebsiella pneumoniae [32].
• Molecular cloning and characterization of a cDNA encoding a bovine butanediol dehydrogenase [33].
• Reversed-phase high-performance liquid chromatography with gradient elution was used for the separation of the analyte from the internal standard (2,3-butanediol) [34].
• At each flow, multiple indicator-dilution curves were collected using 14C-labeled urea (U) or butanediol (B) as the diffusing tracer, and radiolabeled 15-microns microspheres were injected [35].

References