High impact information on Osmitrol

• Prolonged exposure (2-4 weeks) of mesangial cells to HG but not to M, as well as growing cells on BSA-AGE and, to a lesser extent, BSA-AM, induced or significantly increased the expression of Gal-3, both protein (up to 2.65-fold) and mRNA (up to 3.10-fold) and its secretion in the medium (by approximately 50%) [1].
• Each month intestinal permeability was measured by the differential uptake of orally administered lactulose (L) and mannitol (M) [2].
• Post hoc regression analysis showed that recoveries of C, S and M were positively related to urinary volume [3].
• The retained plasmid rate was compared between TALP medium M and MT media and resulted in a percentage of 1.0, 2.5, 6.5 at 1 microFarads, 100 V, and 0.9, 3.8, and 3.8 at 25 microFarads, 100 V in TALP, MT, and M medium, respectively [4].
• Permeability was measured as a percentage of urinary excretion of lactitol (L, %) and mannitol (M, %) (0.1 g/kg for each, oral absorption after a 6 h fast, 5 h urine collection, analysis by gas chromatography) and determination of the L/M ratio (L/M, %) [5].

Biological context of Osmitrol

• At the end of the study, cell counts and protein losses were higher in the PBS-treated rats than in the other groups (cell count: p < 0.05, Glu vs PBS, and p < 0.05, Man vs PBS; protein in dialysate: p < 0.001, Glu vs PBS, and p < 0.01, Man vs PBS) [6].

Anatomical context of Osmitrol

• Increasing the rate of loop of Henle perfusion with either ATF or M + E resulted in similar decreases in PSF [7].

Associations of Osmitrol with other chemical compounds

• The first, the effect of modifying the composition of fluid used to perfuse the loop of Henle of a single nephron, was studied in rats by comparing flow-induced changes in stop-flow pressure (PSF) with three different perfusion solutions: artificial tubule fluid (ATF); 0.3 M mannitol (M); and mannitol plus 25 to 30 mM sodium chloride (M + E) [7].
• Ten healthy men randomly received either Schering or Invenex gentamicin 1 mg/kg (as the sulfate salt) by intramuscular injection into the deltoid muscle [8].
• Solutions used were: 4% N-acetylglucosamine (NAG), 4% mannitol (M), 4% glucose (G), and control group (C) [9].

Analytical, diagnostic and therapeutic context of Osmitrol

• Electroporation above 100 V in M and MT killed the cells [4].

References