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Chemical Compound Review

Pyroclor 5     1,2,3,4,5-pentachloro-6- phenyl-benzene

Synonyms: Kanekrol 500, Pyralene 1476, CHEMBL275246, AG-E-32410, CHEBI:34219, ...
 
 
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Disease relevance of Pyroclor 5

 

High impact information on Pyroclor 5

 

Biological context of Pyroclor 5

 

Associations of Pyroclor 5 with other chemical compounds

  • Estrogen supplementation modulates effects of the endocrine disrupting pollutant PCB126 in rat bone and uterus: diverging effects in ovariectomized and intact animals [8].
  • 1. Pregnant Wistar rats were treated orally with a single dose of 100 microg 3,3',4,4'-tetrachlorobiphenyl (PCB 77)/kg b.w. or 10 microg 3,3',4,4',5 pentachlorobiphenyl (PCB 126)/kg b.w. on day 15 of pregnancy [9].
  • We measured in-ovo CYP1A catalytic activity (ethoxyresorufin-O-deethylase, EROD) in NB and reference site killifish embryos aqueously exposed to various concentrations of the de-methylating agent 5-azacytidine, 5-AC (5, 50 and 500 micro(micro)M) with or without 0.2 micro(micro)g/l of the CYP1A inducer 3,3',4,4',5 pentachlorobiphenyl (IUPAC PCB126) [10].
 

Gene context of Pyroclor 5

  • Incubation with TCDD or PCB126 with or without serum caused a concentration-dependent decrease in the aromatase activity of up to 4.9-fold [6].
 

Analytical, diagnostic and therapeutic context of Pyroclor 5

  • Interactive effects between the non-ortho-substituted 3,3', 4,4', 5-pentachlorobiphenyl (PCB126), the mono-ortho-substituted 2,3,3',4, 4'-pentachlorobiphenyl (PCB105), and the di-ortho-substituted 2,2',4, 4',5,5'-hexachlorobiphenyl (PCB153) were studied in an initiation/promotion bioassay [11].

References

  1. Subchronic toxicity of pentachlorobiphenyl congeners n. 126 or 118 in the rat liver. An electron microscope study. MacLellan, K., Singh, A., Chu, I., Poon, R., Villeneuve, D.C. J. Submicrosc. Cytol. Pathol. (1994) [Pubmed]
  2. Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression. Vezina, C.M., Walker, N.J., Olson, J.R. Environ. Health Perspect. (2004) [Pubmed]
  3. Reductive dechlorination of a polychlorinated biphenyl congener and hexachlorobenzene by vitamin B12. Assaf-Anid, N., Nies, L., Vogel, T.M. Appl. Environ. Microbiol. (1992) [Pubmed]
  4. Specific human CYP 450 isoform metabolism of a pentachlorobiphenyl (PCB-IUPAC# 101). McGraw, J.E., Waller, D.P. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  5. Effects of the antiestrogenic environmental pollutant 3,3',4,4', 5-pentachlorobiphenyl (PCB #126) in rat bone and uterus: diverging effects in ovariectomized and intact animals. Lind, P.M., Eriksen, E.F., Sahlin, L., Edlund, M., Orberg, J. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  6. Effects of some persistent halogenated environmental contaminants on aromatase (CYP19) activity in the human choriocarcinoma cell line JEG-3. Drenth, H.J., Bouwman, C.A., Seinen, W., Van den Berg, M. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  7. The chlorinated AHR ligand 3,3',4,4',5-pentachlorobiphenyl (PCB126) promotes reactive oxygen species (ROS) production during embryonic development in the killifish (Fundulus heteroclitus). Arzuaga, X., Wassenberg, D., Giulio, R.D., Elskus, A. Aquat. Toxicol. (2006) [Pubmed]
  8. Estrogen supplementation modulates effects of the endocrine disrupting pollutant PCB126 in rat bone and uterus: diverging effects in ovariectomized and intact animals. Lind, P.M., Eriksen, E.F., Lind, L., Orberg, J., Sahlin, L. Toxicology (2004) [Pubmed]
  9. Effects on developmental landmarks and reproductive capability of 3,3',4,4'-tetrachlorobiphenyl and 3,3',4,4',5-pentachlorobiphenyl in offspring of rats exposed during pregnancy. Faqi, A.S., Dalsenter, P.R., Merker, H.J., Chahoud, I. Human & experimental toxicology. (1998) [Pubmed]
  10. The DNA de-methylating agent 5-azacytidine does not restore CYP1A induction in PCB resistant Newark Bay killifish (Fundulus heteroclitus). Arzuaga, X., Calcaño, W., Elskus, A. Mar. Environ. Res. (2004) [Pubmed]
  11. Interactive effects of three structurally different polychlorinated biphenyls in a rat liver tumor promotion bioassay. Haag-Grönlund, M., Johansson, N., Fransson-Steen, R., Hâkansson, H., Scheu, G., Wärngård, L. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
 
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