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Chemical Compound Review

AGN-PC-00IO3J     [3-acetamido-4,5-dihydroxy- 6...

Synonyms: AC1L18NU
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Disease relevance of lipid I


High impact information on lipid I


Chemical compound and disease context of lipid I


Anatomical context of lipid I

  • MurG was assayed by addition of UDP-[3H]N-acetylglucosamine to membranes in which lipid I was preformed by incubation with UDP-N-acetyl-muramylpentapeptide, and the product was captured by wheat germ agglutinin scintillation proximity assay beads [11].
  • We characterize two assays of total amniotic fluid surfactant that are based on function: the surface-tension lowering ability of extracts of amniotic fluid lipid (I) and the foam stability index test (II) [12].

Associations of lipid I with other chemical compounds

  • Our results are consistent with the conclusion that the rff-726 mutation is located in the structural gene for the transferase that catalyzes the transfer of ManNAcA from UDP-ManNAcA to lipid I [2].

Gene context of lipid I

  • Formation of the peptidoglycan precursors Lipid I and Lipid II is catalyzed by the gene products of mraY and murG, which are involved in the first and second steps of the lipid cycle reactions, respectively [13].
  • CDS, CTS, CTeS were isolated as minor components (together they accounted for 3% of the total neutral glycolipid fraction), while CMS and the glycolipids (Lipid I, II, and III) with larger saccharide chains that were previously characterized (1--4) occurred as major ones [14].

Analytical, diagnostic and therapeutic context of lipid I

  • Two versions of the assay were developed, one consisting of the high-pressure liquid chromatography separation of the substrate and product (dansylated lipid I) and the other, without separation and adapted to the high-throughput format, taking advantage of the different fluorescence properties of the nucleotide and lipid I in the reaction medium [15].


  1. Acceptor Substrate Selectivity and Kinetic Mechanism of Bacillus subtilis TagA. Zhang, Y.H., Ginsberg, C., Yuan, Y., Walker, S. Biochemistry (2006) [Pubmed]
  2. Characterization of an Escherichia coli rff mutant defective in transfer of N-acetylmannosaminuronic acid (ManNAcA) from UDP-ManNAcA to a lipid-linked intermediate involved in enterobacterial common antigen synthesis. Barr, K., Ward, S., Meier-Dieter, U., Mayer, H., Rick, P.D. J. Bacteriol. (1988) [Pubmed]
  3. Mycobacterial lipid II is composed of a complex mixture of modified muramyl and peptide moieties linked to decaprenyl phosphate. Mahapatra, S., Yagi, T., Belisle, J.T., Espinosa, B.J., Hill, P.J., McNeil, M.R., Brennan, P.J., Crick, D.C. J. Bacteriol. (2005) [Pubmed]
  4. Autolysis of Listeria monocytogenes. Popowska, M., Kłoszewska, M., Górecka, S., Markiewicz, Z. Acta Microbiol. Pol. (1999) [Pubmed]
  5. Colicin M exerts its bacteriolytic effect via enzymatic degradation of undecaprenyl phosphate-linked peptidoglycan precursors. El Ghachi, M., Bouhss, A., Barreteau, H., Touzé, T., Auger, G., Blanot, D., Mengin-Lecreulx, D. J. Biol. Chem. (2006) [Pubmed]
  6. The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity. Boniface, A., Bouhss, A., Mengin-Lecreulx, D., Blanot, D. J. Biol. Chem. (2006) [Pubmed]
  7. Nucleotide sequence of the Escherichia coli rfe gene involved in the synthesis of enterobacterial common antigen. Molecular cloning of the rfe-rff gene cluster. Meier-Dieter, U., Barr, K., Starman, R., Hatch, L., Rick, P.D. J. Biol. Chem. (1992) [Pubmed]
  8. Phosphatidylkojibiosyl diglyceride. The covalently linked lipid constituent of the membrane lipoteichoic acid from Streptococcus faecalis (faecium) ATCC 9790. Ganfield, M.C., Pieringer, R.A. J. Biol. Chem. (1975) [Pubmed]
  9. The total synthesis of lipid I. VanNieuwenhze, M.S., Mauldin, S.C., Zia-Ebrahimi, M., Aikins, J.A., Blaszczak, L.C. J. Am. Chem. Soc. (2001) [Pubmed]
  10. Role of the rfe gene in the synthesis of the O8 antigen in Escherichia coli K-12. Rick, P.D., Hubbard, G.L., Barr, K. J. Bacteriol. (1994) [Pubmed]
  11. Scintillation proximity assay for inhibitors of Escherichia coli MurG and, optionally, MraY. Ravishankar, S., Kumar, V.P., Chandrakala, B., Jha, R.K., Solapure, S.M., de Sousa, S.M. Antimicrob. Agents Chemother. (2005) [Pubmed]
  12. Evaluation of two assays of functional surfactant in amniotic fluid: surface-tension lowering ability and the foam stability index test. Statland, B.E., Freer, D.E. Clin. Chem. (1979) [Pubmed]
  13. Assay for identification of inhibitors for bacterial MraY translocase or MurG transferase. Branstrom, A.A., Midha, S., Longley, C.B., Han, K., Baizman, E.R., Axelrod, H.R. Anal. Biochem. (2000) [Pubmed]
  14. Studies on glycosphingolipids of fresh-water bivalves. VI. Isolation and chemical characterization of neutral glycosphingolipids from spermatozoa of the fresh-water bivalve, Hyriopsis schlegelii. Sugita, M., Yamamoto, T., Masuda, S., Itasaka, O., Hori, T. J. Biochem. (1981) [Pubmed]
  15. Fluorescence detection-based functional assay for high-throughput screening for MraY. Stachyra, T., Dini, C., Ferrari, P., Bouhss, A., van Heijenoort, J., Mengin-Lecreulx, D., Blanot, D., Biton, J., Le Beller, D. Antimicrob. Agents Chemother. (2004) [Pubmed]
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