The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Surface Tension

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Surface Tension


High impact information on Surface Tension

  • The possibility that the lipoprotein complex of lung surfactant functions in pulmonary host defense as well as lowering surface tension at the air-liquid interface has been the subject of renewed interest in light of the finding that surfactant proteins A and D (SP-A and SP-D) are members of a family of proteins known as collectins [6].
  • These data, together with findings that the SP-B-related peptides increase inter- and intramolecular order of the phospholipid layer, suggest that SP-B resists surface tension by increasing lateral stability of the phospholipid layer [7].
  • This value, when used in a simple geometric model for the curvature dependence of the hydrophobic effect, predicts a macroscopic alkane-water surface tension that is close to the macroscopic value [8].
  • We thus conclude that the amyloid-like fibrils of ChpD-H lower the water surface tension to allow aerial growth and cover aerial structures, rendering them hydrophobic [9].
  • The crude surfactant pellet was analyzed for total phospholipids (PL), individual phospholipids, SP-A, SP-B, and minimum surface tension (STmin) [10].

Biological context of Surface Tension


Anatomical context of Surface Tension


Associations of Surface Tension with chemical compounds


Gene context of Surface Tension

  • At lower concentrations, minimum surface tensions were higher for SP-A(-/-) mice [24].
  • Surfactant protein A (SP-A) is the major protein component of pulmonary surfactant, a material secreted by the alveolar type II cell that reduces surface tension at the alveolar air-liquid interface [25].
  • SP-C associates with surfactant lipids to reduce surface tension within the alveolus, maintaining lung volume at end expiration [26].
  • SP-C enhances surface tension lowering activity of surfactant phospholipids that is critical to the maintenance of alveolar volume at end expiration [27].
  • The surface tension measured with a Wilhelmy balance of the rSP-C surfactant was lower than the surface tension of natural sheep surfactant (containing SP-B and SP-C) [28].

Analytical, diagnostic and therapeutic context of Surface Tension

  • The Langmuir trough has been used to study monolayers of surfactant from beef lung extracts, dog lavage and the principal component (dipalmitoyl lecithin; DPL) in which surface tension has been simultaneously monitored on each film by the Wilhelmy method and the original Langmuir method whose readings are independent of contact angle [29].
  • Median minimal surface tension, measured by pulsating bubble surfactometer, was elevated (P < 0.01) in both infection (17.5 mN/m) and CF (17.1 mN/m) compared with the control group (1.5 mN/m) [30].
  • CONCLUSIONS: Exogenous surfactant preceding high peak inspiratory lung volumes prevents impairment of oxygenation, lung mechanics, and minimal surface tension of bronchoalveolar lavage fluid and reduces alveolar influx of Evans blue dye [31].
  • Dilute mixed solutions of non-surface active anionic polymers (polyacrylamide and polystyrene sulfonate, xanthan) and various surfactants have been studied with several methods: surface tension, ellipsometry, X-ray and neutron reflectivity, thin film balance, surface and bulk rheology [32].
  • Minimum surface tensions of alveolar washes fell from greater than 30 dynes/cm to 6.3 dynes/cm 10 min after treatment and again rose to 21.6 dynes/cm within 3 h [33].


  1. Traumatic head injury and pulmonary damage. Crittenden, D.J., Beckman, D.L. The Journal of trauma. (1982) [Pubmed]
  2. Composition and surface properties of the bronchial lipids in adult patients with cystic fibrosis. Gilljam, H., Andersson, O., Ellin, A., Robertson, B., Strandvik, B. Clin. Chim. Acta (1988) [Pubmed]
  3. Mechanical properties of mouse lungs: effects of degassing on normal, hyperoxic, and irradiated lungs. Gross, N.J. Journal of applied physiology: respiratory, environmental and exercise physiology. (1981) [Pubmed]
  4. Effects of distention of the preterm fetal lamb lung on lung function with ventilation. Ikegami, M., Jobe, A., Berry, D., Elkady, T., Pettenazzo, A., Seidner, S. Am. Rev. Respir. Dis. (1987) [Pubmed]
  5. Characterization of surfactin from Bacillus subtilis for application as an agent for enhanced oil recovery. Schaller, K.D., Fox, S.L., Bruhn, D.F., Noah, K.S., Bala, G.A. Appl. Biochem. Biotechnol. (2004) [Pubmed]
  6. Immunomodulatory functions of surfactant. Wright, J.R. Physiol. Rev. (1997) [Pubmed]
  7. Pulmonary surfactant protein B (SP-B): structure-function relationships. Cochrane, C.G., Revak, S.D. Science (1991) [Pubmed]
  8. Reconciling the magnitude of the microscopic and macroscopic hydrophobic effects. Sharp, K.A., Nicholls, A., Fine, R.F., Honig, B. Science (1991) [Pubmed]
  9. A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils. Claessen, D., Rink, R., de Jong, W., Siebring, J., de Vreugd, P., Boersma, F.G., Dijkhuizen, L., Wosten, H.A. Genes Dev. (2003) [Pubmed]
  10. Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. Gregory, T.J., Longmore, W.J., Moxley, M.A., Whitsett, J.A., Reed, C.R., Fowler, A.A., Hudson, L.D., Maunder, R.J., Crim, C., Hyers, T.M. J. Clin. Invest. (1991) [Pubmed]
  11. The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivo. Palaniyar, N., Zhang, L., Kuzmenko, A., Ikegami, M., Wan, S., Wu, H., Korfhagen, T.R., Whitsett, J.A., McCormack, F.X. J. Biol. Chem. (2002) [Pubmed]
  12. Design of peptidyl compounds that affect beta-amyloid aggregation: importance of surface tension and context. Gibson, T.J., Murphy, R.M. Biochemistry (2005) [Pubmed]
  13. Mapping and analysis of the lytic and fusogenic domains of surfactant protein B. Ryan, M.A., Qi, X., Serrano, A.G., Ikegami, M., Perez-Gil, J., Johansson, J., Weaver, T.E. Biochemistry (2005) [Pubmed]
  14. Adsorption of trichloroethene at the vapor/water interface. Bruant, R.G., Conklin, M.H. Environ. Sci. Technol. (2001) [Pubmed]
  15. Comparison of inhibitory effects of oxygen radicals and calf serum protein on surfactant activity. Lee, M.M., Green, F.H., Schürch, S., Cheng, S., Bjarnason, S.G., Leonard, S., Wallace, W., Possmayer, F., Vallyathan, V. Mol. Cell. Biochem. (2004) [Pubmed]
  16. Dysfunction of pulmonary surfactant in asthmatics after segmental allergen challenge. Hohlfeld, J.M., Ahlf, K., Enhorning, G., Balke, K., Erpenbeck, V.J., Petschallies, J., Hoymann, H.G., Fabel, H., Krug, N. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  17. Evaluation of two assays of functional surfactant in amniotic fluid: surface-tension lowering ability and the foam stability index test. Statland, B.E., Freer, D.E. Clin. Chem. (1979) [Pubmed]
  18. Resistance of different surfactant preparations to inactivation by meconium. Herting, E., Rauprich, P., Stichtenoth, G., Walter, G., Johansson, J., Robertson, B. Pediatr. Res. (2001) [Pubmed]
  19. Surface tension and contact angle on enamel of surfactant solutions for caries diagnosis with dyes. Van de Rijke, J.W., Busscher, H.J., Ten Bosch, J.J., Perdok, J.F. J. Dent. Res. (1989) [Pubmed]
  20. Bacterial cell surface hydrophobicity properties in the mediation of in vitro adhesion by the rabbit enteric pathogen Escherichia coli strain RDEC-1. Drumm, B., Neumann, A.W., Policova, Z., Sherman, P.M. J. Clin. Invest. (1989) [Pubmed]
  21. Experimental disintegration of the nuclear envelope. Evidence for pore-connecting fibrils. Scheer, U., Kartenbeck, J., Trendelenburg, M.F., Stadler, J., Franke, W.W. J. Cell Biol. (1976) [Pubmed]
  22. Formation of lung surfactant films from intact lamellar bodies. Paul, G.W., Hassett, R.J., Reiss, O.K. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  23. Surface tension measurements show that chaotropic salting-in denaturants are not just water-structure breakers. Breslow, R., Guo, T. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  24. Altered surfactant function and structure in SP-A gene targeted mice. Korfhagen, T.R., Bruno, M.D., Ross, G.F., Huelsman, K.M., Ikegami, M., Jobe, A.H., Wert, S.E., Stripp, B.R., Morris, R.E., Glasser, S.W., Bachurski, C.J., Iwamoto, H.S., Whitsett, J.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  25. Surfactant protein A (SP-A): the alveolus and beyond. Khubchandani, K.R., Snyder, J.M. FASEB J. (2001) [Pubmed]
  26. Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice. Bridges, J.P., Wert, S.E., Nogee, L.M., Weaver, T.E. J. Biol. Chem. (2003) [Pubmed]
  27. Tumor necrosis factor-alpha inhibits surfactant protein C gene transcription. Bachurski, C.J., Pryhuber, G.S., Glasser, S.W., Kelly, S.E., Whitsett, J.A. J. Biol. Chem. (1995) [Pubmed]
  28. Lung function in premature lambs and rabbits treated with a recombinant SP-C surfactant. Davis, A.J., Jobe, A.H., Häfner, D., Ikegami, M. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  29. Alveolar liquid lining: Langmuir method used to measure surface tension in bovine and canine lung extracts. Hills, B.A. J. Physiol. (Lond.) (1985) [Pubmed]
  30. Altered phospholipid composition and aggregate structure of lung surfactant is associated with impaired lung function in young children with respiratory infections. Mander, A., Langton-Hewer, S., Bernhard, W., Warner, J.O., Postle, A.D. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  31. Exogenous surfactant preserves lung function and reduces alveolar Evans blue dye influx in a rat model of ventilation-induced lung injury. Verbrugge, S.J., Vazquez de Anda, G., Gommers, D., Neggers, S.J., Sorm, V., Böhm, S.H., Lachmann, B. Anesthesiology (1998) [Pubmed]
  32. Polyelectrolyte and surfactant mixed solutions. behavior at surfaces and in thin films. Langevin, D. Advances in colloid and interface science. (2001) [Pubmed]
  33. Premature lambs rescued from respiratory failure with natural surfactant: clinical and biophysical correlates. Jacobs, H., Jobe, A., Ikegami, M., Glatz, T., Jones, S.J., Barajas, L. Pediatr. Res. (1982) [Pubmed]
WikiGenes - Universities