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Chemical Compound Review

CBDivE_006286     5-[(4-hydroxy-2,6-dioxo-3H- pyrimidin-5...

Synonyms: SureCN13317625, Oprea1_600173, AC1L2BPU, AC1Q6LTL
 
 
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Disease relevance of Murexide

  • Mitochondria of malignant hyperthermia pigs contained significantly (P less than 0.001) higher quantities of endogenous Ca2+ and showed a significantly (P less than 0.001) faster FCCP-induced endogenous Ca2+ efflux rate than normal when monitored spectroscopically with murexide [1].
 

High impact information on Murexide

  • One described the use of murexide in molluscan smooth muscle, the other the use of aequorin in single amphibian cells [2].
  • Mitochondrial and sarcoplasmic reticulum (SR) calcium accumulation was measured both by dual wavelength spectrophotometry with the calcium-sensitive dye, murexide, and by Millipore filtration with 45Ca [3].
  • Changes in Ca2+ binding after phosphorylation of membranous or detergent-solubilized preparations of sarcoplasmic reticulum Ca2+-ATPase with ATP were followed spectrophotometrically by the use of murexide [4].
  • A technique for studying the binding of La3+ to synaptosomes in a double-beam spectrophotometer, using murexide as indicator, is described [5].
  • Membrane potential was determined by use of the fluorescence-sensitive dye, 3,3'-diethylthiadicarbocyanine, and Ca2+ uptake was studied spectrophotometrically with the use of murexide [6].
 

Anatomical context of Murexide

  • Using a DW 2 dual wavelength spectrophotometer (AMINCO) and murexide as a Ca2+ sensitive indicator it is shown that guinea-pig heart mitochondria can release accumulated Ca2+ without the influence of non-physiological material [7].
  • Ca2+-transport across mitochondrial membranes was measured continuously with an Aminco Dual-Wavelength-Spectrophotometer and murexide as a Ca2+-sensitive indicator [8].
 

Associations of Murexide with other chemical compounds

  • The apparent binding constant (K E app) of EGTA to Ca2+ was determined using a color indicator, murexide, or a Ca2+-selective electrode in the pH range between 6.5 and 7.5, at 5 degrees C and at 20 degrees C. K E app values obtained at two different temperatures (5 degrees C and 20 degrees C) were essentially the same when measured at the same pH [9].
  • In the presence of ruthenium red, both rat liver and beef heart mitochondria release sequestered Ca2+ with arsenazo III, but not with murexide [10].
 

Gene context of Murexide

  • Whole casein had no effect on the absorption spectra of calcium murexide and no affinity for calcium murexide complex or murexide ion [11].
  • A spectrophotometric competition assay using the metallochromic indicator murexide showed that histatin 5 dissociates metal indicator complexes containing zinc or copper ions [12].
 

Analytical, diagnostic and therapeutic context of Murexide

References

  1. Mitochondrial calcium transport and calcium-activated phospholipase in porcine malignant hyperthermia. Cheah, K.S., Cheah, A.M. Biochim. Biophys. Acta (1981) [Pubmed]
  2. Use of aequorin to study excitation--contraction coupling in mammalian smooth muscle. Neering, I.R., Morgan, K.G. Nature (1980) [Pubmed]
  3. Action of caffeine on calcium transport by isolated fractions of myofibrils, mitochondria, and sarcoplasmic reticulum from rabbit heart. Blayney, L., Thomas, H., Muir, J., Henderson, A. Circ. Res. (1978) [Pubmed]
  4. Changes in Ca2+ affinity related to conformational transitions in the phosphorylated state of soluble monomeric Ca2+-ATPase from sarcoplasmic reticulum. Andersen, J.P., Lassen, K., Møller, J.V. J. Biol. Chem. (1985) [Pubmed]
  5. Binding of lanthanum ions and ruthenium red to synaptosomes and its effects on neurotransmitter release. Tapia, R., Arias, C., Morales, E. J. Neurochem. (1985) [Pubmed]
  6. Alterations of membrane potential and Ca2+ flux of sarcoplasmic reticulum vesicles in ischemic myocardium. Peng, C.F., Straub, K.D., Murphy, M.L. Ann. Clin. Lab. Sci. (1983) [Pubmed]
  7. The release of calcium from cardiac mitochondria: the importance of the calcium-protein ratio. Göring, G.G., Nayler, W.G., Spieckermann, P.G. Basic Res. Cardiol. (1977) [Pubmed]
  8. Ca2+-uptake and -release phenomena from cardiac mitochondria under normal and ischemic conditions. Göring, G.G., Spieckermann, P.G. Basic Res. Cardiol. (1978) [Pubmed]
  9. The apparent binding constants of Ca2+ to EGTA and heavy meromyosin. Matsuda, S., Yagi, K. J. Biochem. (1980) [Pubmed]
  10. Interaction of metallochromic indicators with calcium sequestering organelles. Ohnishi, S.T. Biochim. Biophys. Acta (1979) [Pubmed]
  11. Murexide for determination of free and protein-bound calcium in model systems. Sundararajan, N.R., Whitney, R.M. J. Dairy Sci. (1975) [Pubmed]
  12. Is salivary histatin 5 a metallopeptide? Gusman, H., Lendenmann, U., Grogan, J., Troxler, R.F., Oppenheim, F.G. Biochim. Biophys. Acta (2001) [Pubmed]
  13. Dynamic properties of isolated acetylcholine receptor proteins: release of calcium ions caused by acetylcholine binding. Chang, H.W., Neumann, E. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  14. Measurement of ionised calcium in body fluids-a review. Robertson, W.G. Ann. Clin. Biochem. (1976) [Pubmed]
 
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