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Chemical Compound Review:

Neb-MS (3S)-3-[[(1S)-1-[[(1S)-1- [[(1S)-1-[[(1S)-1...

Synonyms: AC1L53K1, 143458-86-0, Dromyosuppressin, Neomyosuppressin, Leucomyosuppressin, 1-L-threonine-, ...

Richer, S. et al., Kaminski, S. et al., Tibbetts, M.F. et al., Johnson, E.C. et al., Fónagy, A. et al., et al.

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Disease relevance of Dromyosuppressin

Dromyosuppressin-like immunoreactive fibers were detected in the cardiac recurrent nerve, hypocerebral ganglion/corpora cardiaca complex, crop duct, and crop [1].

High impact information on Dromyosuppressin

To corroborate the findings on orphan receptors obtained by the translocation assay, we show that dromyosuppressin also stimulated GTPgammaS binding and inhibited cAMP by CG8985 and CG13803 [2].
Innervation of the crop and crop duct by dromyosuppressin immunoreactive processes that originated in the central nervous system and the effect of dromyosuppressin on crop muscle contractions suggest that dromyosuppressin is released locally to modulate crop contractions and that crop motility is under neural regulation [1].
Application of 1 microl 10(-6) M dromyosuppressin or 1 microl 10(-3) M benzethonium chloride to the crop slowed the rate to 2.2 +/- 0.2 and 6.1 +/- 0.7 contractions per minute, respectively [1].
The structures of DMS, FLT, and SDNFMRFamide differ and each peptide is encoded by a different gene [3].
In addition, the spatial and temporal distributions of DMS, FLT, and SDNFMRFamide are dissimilar [3].

Biological context of Dromyosuppressin

DMS, FLT, and SDNFMRFamide each decreases heart rate; however, their effects are profoundly different [3].
Dromyosuppressin (DMS; TDVDHVFLRFamide) is an abundant peptide isolated from adult Drosophila which shares a high degree of sequence homology with peptides isolated from chicken, cockroach, fleshfly, and locust [4].

Anatomical context of Dromyosuppressin

Antibody to the dipteran myosuppressin peptide, dromyosuppressin, TDVDHVFLRFamide, stained cells and fibers in the brain, optic lobes, subesophageal ganglion, and thoracico-abdominal ganglion of the blow fly, Phormia regina (Meigen) [1].
5. The threshold level of synthetic Neb-MS was found to be 8.6 +/- 0.5 x 10(-11) M on the Leucophaea hindgut and 3.4 +/- 0.5 x 10(-10) M on the Locusta oviduct bioassay, respectively [5].

Gene context of Dromyosuppressin

Dromyosuppressin and drosulfakinin, two structurally related Drosophila neuropeptides, are uniquely expressed in the adult central nervous system [6].

References

Innervation of dromyosuppressin (DMS) immunoreactive processes and effect of DMS and benzethonium chloride on the Phormia regina (Meigen) crop. Richer, S., Stoffolano, J.G., Yin, C.M., Nichols, R. J. Comp. Neurol. (2000) [Pubmed]
Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. Johnson, E.C., Bohn, L.M., Barak, L.S., Birse, R.T., Nässel, D.R., Caron, M.G., Taghert, P.H. J. Biol. Chem. (2003) [Pubmed]
The effects of three Drosophila melanogaster myotropins on the frequency of foregut contractions differ. Kaminski, S., Orlowski, E., Berry, K., Nichols, R. J. Neurogenet. (2002) [Pubmed]
Immunocytochemistry of sequence-related neuropeptides in Drosophila. Tibbetts, M.F., Nichols, R. Neuropeptides (1993) [Pubmed]
Isolation, primary structure and synthesis of neomyosuppressin, a myoinhibiting neuropeptide from the grey fleshfly, Neobellieria bullata. Fónagy, A., Schoofs, L., Proost, P., Van Damme, J., Bueds, H., De Loof, A. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1992) [Pubmed]
Dromyosuppressin and drosulfakinin, two structurally related Drosophila neuropeptides, are uniquely expressed in the adult central nervous system. Nichols, R., McCormick, J., Lim, I. Ann. N. Y. Acad. Sci. (1997) [Pubmed]

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