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Chemical Compound Review

Annetocin     (2S)-1- [[(4S,7S,10S,13S,16S,19S)-19- amino...

Synonyms: AC1L53SG, 154445-03-1
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Disease relevance of Annetocin


High impact information on Annetocin


Biological context of Annetocin


Anatomical context of Annetocin

  • Dose-response relationship of the effects of annetocin and its related peptides on the annelid and mammalian systems shows that amino acid residue at the third position of these peptides is important for exertion of excitatory action on the smooth muscle systems [7].
  • On the other hand, oxytocin, vasotocin, Arg-vasopressin, Lys-vasopressin, and tocinoic acid caused spontaneous contractions of isolated rat uterine preparations, where the potency was in this order, while annetocin and MIF exerted no oxytocic activity on the uterus [7].

Gene context of Annetocin


Analytical, diagnostic and therapeutic context of Annetocin

  • Optimization of a real-time quantitative PCR procedure exploiting the fluorescent DNA-binding molecule, Sybr Green, has allowed the measurement of annetocin transcript levels over a range covering six orders of magnitude [4].


  1. Possible functions of oxytocin/vasopressin-superfamily peptides in annelids with special reference to reproduction and osmoregulation. Fujino, Y., Nagahama, T., Oumi, T., Ukena, K., Morishita, F., Furukawa, Y., Matsushima, O., Ando, M., Takahama, H., Satake, H., Minakata, H., Nomoto, K. J. Exp. Zool. (1999) [Pubmed]
  2. Evidence for conservation of the vasopressin/oxytocin superfamily in Annelida. Satake, H., Takuwa, K., Minakata, H., Matsushima, O. J. Biol. Chem. (1999) [Pubmed]
  3. Annetocin: an oxytocin-related peptide isolated from the earthworm, Eisenia foetida. Oumi, T., Ukena, K., Matsushima, O., Ikeda, T., Fujita, T., Minakata, H., Nomoto, K. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  4. Measurement of annetocin gene expression: a new reproductive biomarker in earthworm ecotoxicology. Ricketts, H.J., Morgan, A.J., Spurgeon, D.J., Kille, P. Ecotoxicol. Environ. Saf. (2004) [Pubmed]
  5. Annetocin, an annelid oxytocin-related peptide, induces egg-laying behavior in the earthworm, Eisenia foetida. Oumi, T., Ukena, K., Matsushima, O., Ikeda, T., Fujita, T., Minakata, H., Nomoto, K. J. Exp. Zool. (1996) [Pubmed]
  6. Identification of a novel receptor for an invertebrate oxytocin/vasopressin superfamily peptide: molecular and functional evolution of the oxytocin/vasopressin superfamily. Kawada, T., Kanda, A., Minakata, H., Matsushima, O., Satake, H. Biochem. J. (2004) [Pubmed]
  7. Effects of annetocin, an oxytocin-related peptide isolated from the earthworm Eisenia foetida, and some putative neurotransmitters on gut motility of the earthworm. Ukena, K., Oumi, T., Matsushima, O., Ikeda, T., Fujita, T., Minakata, H., Nomoto, K. J. Exp. Zool. (1995) [Pubmed]
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