Disease relevance of C07773

• Influence of food on serum ambenonium concentration in patients with myasthenia gravis [1].

Psychiatry related information on C07773

• The hierarchic order in the sequence of diffusion from the CSF into the hemispheric subpial regions and the distribution pattern of Am resemble the stereotypic topographic expansion pattern and the predominantly limbic distribution of neurofibrillary tangles (NFTs) in Alzheimer's disease and related conditions [2].

High impact information on C07773

• These models indicated that ambenonium and acetylthiocholine competed for a peripheral anionic site in the acetyl-enzyme intermediate formed during substrate hydrolysis [3].
• We found that the distribution of Am-protected AChE (indicating the Am itself) is similar to tracers having no intracerebral binding sites [2].
• Ambenonium is known to be an inhibitor of acetylcholinesterase, and recent data have shown this drug to antagonize muscarinic receptors as well [4].
• The Schild regressions obtained for ambenonium antagonism of acetylcholine responses formally satisfied criteria for simple competitive antagonism of a homogenous population of receptors (linear regression, slope equal to unity) [4].
• This latter property was confirmed by Schild analyses of ambenonium-induced blockade of responses to bethanechol in guinea-pig ileal longitudinal smooth muscle, taenia caeci, trachea and rat anococcygeus muscle [4].

Biological context of C07773

• Physostigmine and ambenonium also have different effects on heart rate in vivo, the former potentiating and the latter apparently blocking vagal tone [5].
• This assay procedure was used to study the pharmacokinetics of ambenonium ion after intravenous administration in rats [6].
• Appearance of tolerance in the increase of contractile muscle tension by ambenonium in rats [7].

Anatomical context of C07773

• To determine whether group II mGluRs modulate the release of the neurotransmitter acetylcholine from starburst amacrine cells, the effect of DCG-IV on ON-OFF DS RGCs was examined in the presence of ambenonium, an acetylcholinesterase inhibitor [8].
• Ambenonium was more specific, and other compounds were less specific inhibitors of motor endplate cholinesterase [9].
• The relationship between the concentration of ambenonium (AMB), a selective and reversible acetylcholinesterase (AChE) inhibitor, in plasma and the potentiation of contractile muscle tension was investigated using a sciatic nerve-muscle preparation of rat [7].

Associations of C07773 with other chemical compounds

• The capacity of acetylcholinesterase inhibitors, with the exception of tacrine and ambenonium, to displace bound [3H]-oxotremorine-M in preference to [3H]quinuclinidyl benzilate predicts that the former compounds could act as potential agonists at muscarinic receptors [10].
• Rapid decrease of heart rate was observed after edrophonium and ambenonium administration, and rapid recovery to the basal level within 1 min [11].

Gene context of C07773

• Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors [12].
• A sensitive analytical method for the determination of ambenonium, a selective acetylcholinesterase inhibitor, in plasma was developed [13].

Analytical, diagnostic and therapeutic context of C07773

• Determination of ambenonium in biological samples by reversed-phase ion-pair liquid chromatography [6].

References