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Chemical Compound Review

Zofenoprilat     (2S,4S)-1-[(2R)-2-methyl-3- sulfanyl...

Synonyms: Zofenoprilate, Zofenoprilatum, CHEMBL16332, AC1MHWT3, CHEBI:116567, ...
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High impact information on Zofenoprilat


Biological context of Zofenoprilat


Gene context of Zofenoprilat

  • Ox-LDL and TNF-alpha increased the activation of NF-kappaB and the preincubation of HUVECs with zofenoprilat, but not with enalaprilat, dose dependently reduced its activation (P <.001) [7].
  • Indeed, the S-thiolation of ALR2 by ZSSG occurred exclusively through the insertion of the Zofenoprilat moiety of ZSSG on the enzyme [8].
  • Zofenoprilat, an antioxidant thiol compound, mimics the effect of GSH [9].


  1. Fosinopril. Clinical pharmacokinetics and clinical potential. Shionoiri, H., Naruse, M., Minamisawa, K., Ueda, S., Himeno, H., Hiroto, S., Takasaki, I. Clinical pharmacokinetics. (1997) [Pubmed]
  2. Fibroblast growth factor-2 mediates Angiotensin-converting enzyme inhibitor-induced angiogenesis in coronary endothelium. Donnini, S., Solito, R., Giachetti, A., Granger, H.J., Ziche, M., Morbidelli, L. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  3. The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets. Lupi, R., Del Guerra, S., Bugliani, M., Boggi, U., Mosca, F., Torri, S., Del Prato, S., Marchetti, P. Eur. J. Endocrinol. (2006) [Pubmed]
  4. Hydrochlorothiazide increases plasma or tissue angiotensin-converting enzyme-inhibitor drug levels in rats with myocardial infarction: differential effects on lisinopril and zofenopril. Westendorp, B., Schoemaker, R.G., van Gilst, W.H., van Veldhuisen, D.J., Buikema, H. Eur. J. Pharmacol. (2005) [Pubmed]
  5. Coronary vasodilation induced by captopril and zofenoprilat: evidence for a prostaglandin-independent mechanism. van Wijngaarden, J., Tio, R.A., van Gilst, W.H., de Graeff, P.A., de Langen, C.D., Wesseling, H. Naunyn Schmiedebergs Arch. Pharmacol. (1991) [Pubmed]
  6. Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. Dal Bo, L., Mazzucchelli, P., Marzo, A. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
  7. Zofenopril inhibits the expression of adhesion molecules on endothelial cells by reducing reactive oxygen species. Cominacini, L., Pasini, A., Garbin, U., Evangelista, S., Crea, A.E., Tagliacozzi, D., Nava, C., Davoli, A., LoCascio, V. Am. J. Hypertens. (2002) [Pubmed]
  8. Zofenoprilat-glutathione mixed disulfide as a specific S-thiolating agent of bovine lens aldose reductase. Dal Monte, M., Del Corso, A., Moschini, R., Cappiello, M., Amodeo, P., Mura, U. Antioxid. Redox Signal. (2005) [Pubmed]
  9. Site-specific inactivation of aldose reductase by 4-hydroxynonenal. Del Corso, A., Dal Monte, M., Vilardo, P.G., Cecconi, I., Moschini, R., Banditelli, S., Cappiello, M., Tsai, L., Mura, U. Arch. Biochem. Biophys. (1998) [Pubmed]
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