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Gene Review

PRDX3  -  peroxiredoxin 3

Bos taurus

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Disease relevance of PRDX3


Psychiatry related information on PRDX3

  • The singlet oxygen-mediated damage to SOD and catalase may result in the perturbation of cellular antioxidant defense mechanisms and subsequently lead to a pro-oxidant condition [6].

High impact information on PRDX3


Chemical compound and disease context of PRDX3


Biological context of PRDX3


Anatomical context of PRDX3


Associations of PRDX3 with chemical compounds


Regulatory relationships of PRDX3

  • Natural bovine lactoferrin inhibited oxidation in buffered corn oil emulsions and lecithin liposome systems at pH 6.6 and 50 degrees C. The antioxidant activity increased with lactoferrin concentration in both phosphate- and Tris-buffered emulsions, but not in both buffered liposome systems [26].
  • The correlation between the levels of some antioxidant enzymes and compounds with progesterone levels indicates that antioxidative mechanisms are activated to cope with steroidogenesis dependent oxyradical formation in the bovine corpus luteum [27].
  • We studied whether antioxidant-surfactant liposomes increase cellular antioxidant activity in alveolar type II cells and whether this effect is influenced by the presence of surfactant protein A (SP-A) [28].

Other interactions of PRDX3


Analytical, diagnostic and therapeutic context of PRDX3


  1. Structure-function analysis of recombinant substrate protein 22 kDa (SP-22). A mitochondrial 2-CYS peroxiredoxin organized as a decameric toroid. Gourlay, L.J., Bhella, D., Kelly, S.M., Price, N.C., Lindsay, J.G. J. Biol. Chem. (2003) [Pubmed]
  2. Purification and characterization of a substrate protein for mitochondrial ATP-dependent protease in bovine adrenal cortex. Watabe, S., Kohno, H., Kouyama, H., Hiroi, T., Yago, N., Nakazawa, T. J. Biochem. (1994) [Pubmed]
  3. Aspirin increases ferritin synthesis in endothelial cells: a novel antioxidant pathway. Oberle, S., Polte, T., Abate, A., Podhaisky, H.P., Schröder, H. Circ. Res. (1998) [Pubmed]
  4. Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols. Motterlini, R., Foresti, R., Bassi, R., Calabrese, V., Clark, J.E., Green, C.J. J. Biol. Chem. (2000) [Pubmed]
  5. Antioxidant function of the mitochondrial protein SP-22 in the cardiovascular system. Araki, M., Nanri, H., Ejima, K., Murasato, Y., Fujiwara, T., Nakashima, Y., Ikeda, M. J. Biol. Chem. (1999) [Pubmed]
  6. Inactivation of catalase and superoxide dismutase by singlet oxygen derived from photoactivated dye. Kim, S.Y., Kwon, O.J., Park, J.W. Biochimie (2001) [Pubmed]
  7. Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST. Manevich, Y., Feinstein, S.I., Fisher, A.B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide. Thom, S.R., Fisher, D., Xu, Y.A., Notarfrancesco, K., Ischiropoulos, H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  9. Parasite-mediated nuclear factor kappaB regulation in lymphoproliferation caused by Theileria parva infection. Palmer, G.H., Machado, J., Fernandez, P., Heussler, V., Perinat, T., Dobbelaere, D.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  10. Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. Arnal, J.F., Clamens, S., Pechet, C., Negre-Salvayre, A., Allera, C., Girolami, J.P., Salvayre, R., Bayard, F. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  11. Modification of enzymatic antioxidants in retinal microvascular cells by glucose or advanced glycation end products. Paget, C., Lecomte, M., Ruggiero, D., Wiernsperger, N., Lagarde, M. Free Radic. Biol. Med. (1998) [Pubmed]
  12. Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition. Ronis, M.J., Butura, A., Sampey, B.P., Shankar, K., Prior, R.L., Korourian, S., Albano, E., Ingelman-Sundberg, M., Petersen, D.R., Badger, T.M. Free Radic. Biol. Med. (2005) [Pubmed]
  13. Induction of manganese superoxide dismutase by glucocorticoids in glomerular cells. Yoshioka, T., Kawamura, T., Meyrick, B.O., Beckman, J.K., Hoover, R.L., Yoshida, H., Ichikawa, I. Kidney Int. (1994) [Pubmed]
  14. The beta-adrenergic receptor antagonist metipranolol blunts zinc-induced photoreceptor and RPE apoptosis. Osborne, N.N., Wood, J.P. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  15. Retinal glutamate in diabetes and effect of antioxidants. Kowluru, R.A., Engerman, R.L., Case, G.L., Kern, T.S. Neurochem. Int. (2001) [Pubmed]
  16. The cDNA sequence encoding bovine SP-22, a new defence system against reactive oxygen species in mitochondria. Hiroi, T., Watabe, S., Takimoto, K., Yago, N., Yamamoto, Y., Takahashi, S.Y. DNA Seq. (1996) [Pubmed]
  17. Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools. James, A.M., Cochemé, H.M., Smith, R.A., Murphy, M.P. J. Biol. Chem. (2005) [Pubmed]
  18. Cyclic strain activates redox-sensitive proline-rich tyrosine kinase 2 (PYK2) in endothelial cells. Cheng, J.J., Chao, Y.J., Wang, D.L. J. Biol. Chem. (2002) [Pubmed]
  19. Effect of cell substrate on antioxidant enzyme activities in cultured renal glomerular epithelium. Yang, A.H., Oberley, T.D., Oberley, L.W., Ramanathan, R. Am. J. Pathol. (1988) [Pubmed]
  20. Extracellular superoxide dismutase (EC-SOD) binds to type i collagen and protects against oxidative fragmentation. Petersen, S.V., Oury, T.D., Ostergaard, L., Valnickova, Z., Wegrzyn, J., Thøgersen, I.B., Jacobsen, C., Bowler, R.P., Fattman, C.L., Crapo, J.D., Enghild, J.J. J. Biol. Chem. (2004) [Pubmed]
  21. Antioxidant effects of calcium channel blockers against free radical injury in endothelial cells. Correlation of protection with preservation of glutathione levels. Mak, I.T., Boehme, P., Weglicki, W.B. Circ. Res. (1992) [Pubmed]
  22. Ascorbate is a potent antioxidant against peroxynitrite-induced oxidation reactions. Evidence that ascorbate acts by re-reducing substrate radicals produced by peroxynitrite. Kirsch, M., de Groot, H. J. Biol. Chem. (2000) [Pubmed]
  23. Augmentation of macrophage growth-stimulating activity of lipids by their peroxidation. Yui, S., Yamazaki, M. J. Immunol. (1990) [Pubmed]
  24. Ceramide-induced intracellular oxidant formation, iron signaling, and apoptosis in endothelial cells: protective role of endogenous nitric oxide. Matsunaga, T., Kotamraju, S., Kalivendi, S.V., Dhanasekaran, A., Joseph, J., Kalyanaraman, B. J. Biol. Chem. (2004) [Pubmed]
  25. Oxidation and nitrosation in the nitrogen monoxide/superoxide system. Daiber, A., Frein, D., Namgaladze, D., Ullrich, V. J. Biol. Chem. (2002) [Pubmed]
  26. Effect of lactoferrin on oxidative stability of corn oil emulsions and liposomes. Huang, S.W., Satué-Gracia, M.T., Frankel, E.N., German, J.B. J. Agric. Food Chem. (1999) [Pubmed]
  27. Antioxidant capacity is correlated with steroidogenic status of the corpus luteum during the bovine estrous cycle. Rapoport, R., Sklan, D., Wolfenson, D., Shaham-Albalancy, A., Hanukoglu, I. Biochim. Biophys. Acta (1998) [Pubmed]
  28. Uptake of antioxidants in surfactant liposomes by cultured alveolar type II cells is enhanced by SP-A. Walther, F.J., David-Cu, R., Supnet, M.C., Longo, M.L., Fan, B.R., Bruni, R. Am. J. Physiol. (1993) [Pubmed]
  29. Expression of peroxiredoxins in bovine oocytes and embryos produced in vitro. Leyens, G., Knoops, B., Donnay, I. Mol. Reprod. Dev. (2004) [Pubmed]
  30. Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells. Trigona, W.L., Mullarky, I.K., Cao, Y., Sordillo, L.M. Biochem. J. (2006) [Pubmed]
  31. Immunohistochemical analysis of bFGF, TGF-beta1 and catalase in rectus abdominis muscle from cattle foetuses at 180 and 260 days post-conception. Orzechowski, A., Gajkowska, B., Wojewódzka, U., Cassar-Malek, I., Picard, B., Hocquette, J.F. Tissue & cell. (2002) [Pubmed]
  32. Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation. Handy, D.E., Zhang, Y., Loscalzo, J. J. Biol. Chem. (2005) [Pubmed]
  33. Role of membrane-associated Ca+ dependent matrix metalloprotease-2 in the oxidant activation of Ca2+Atpase by tertiary butylhydroperoxide. Das, S., Chakraborti, T., Mandal, M., Mandal, A., Chakraborti, S. Mol. Cell. Biochem. (2002) [Pubmed]
  34. Absence of hemoprotein-associated free radical events following oxidant challenge of crosslinked hemoglobin-superoxide dismutase catalase. D'Agnillo, F., Chang, T.M. Free Radic. Biol. Med. (1998) [Pubmed]
  35. Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase. Yan, H., Harding, J.J. Biochem. J. (1997) [Pubmed]
  36. Redox reactions of the urate radical/urate couple with the superoxide radical anion, the tryptophan neutral radical and selected flavonoids in neutral aqueous solutions. Santus, R., Patterson, L.K., Filipe, P., Morlière, P., Hug, G.L., Fernandes, A., Mazière, J.C. Free Radic. Res. (2001) [Pubmed]
  37. Microtubulin configuration and mitochondrial distribution after ultra-rapid cooling of bovine oocytes. Rho, G.J., Kim, S., Yoo, J.G., Balasubramanian, S., Lee, H.J., Choe, S.Y. Mol. Reprod. Dev. (2002) [Pubmed]
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