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Chemical Compound Review: 

LS-161133     3-diethylaminopropyl 3-methyl-2-phenyl...

Synonyms: AC1MI0OL, C 1998, 78372-13-1
This record was replaced with 3060943.
 
 
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Disease relevance of 3-diethylaminopropyl 3-methyl-2-phenyl-pentanoate

  • In addition, it shows that the hepatitis C virus polymerase was crystallized in a closed fingers conformation, similar to HIV-1 reverse transcriptase in ternary complex with DNA and dTTP [Huang H., Chopra, R., Verdine, G. L. & Harrison, S. C. (1998) Science 282, 1669-1675] [1].
 

High impact information on 3-diethylaminopropyl 3-methyl-2-phenyl-pentanoate

  • Similar results were obtained with the Sxl homologue of Ceratitis capitata (Saccone, G., Peluso, I., Artiaco, D. , Giodano, E., Bopp, D. and Polito, L. C. (1998) Development 125, 1495-1500) suggesting that, in these non-drosophilid species, Sxl performs a function different from that in sex determination [2].
  • We have shown that a subset of early postmitotic progenitors that originates along the medial part of the epithelial somite gives rise to the primary myotome (Kahane, N., Cinnamon, Y. and Kalcheim, C. (1998). Mech. Dev. 74, 59-73) [3].
  • These results, along with the previous report in which AR was shown to directly interact with Rb (Yeh, S., Miyamoto, H., Nishimura, K., Kang, H., Ludlow, J., Hsiao, P., Wang, C., Su, C., and Chang C. (1998) Biochem. Biophys. Res. Commun. 248, 361-367), suggest that the AR-ASC-2 interactions in vivo may involve Rb [4].
  • Exchanging the identity of amino acids at four key locations within the Arabidopsis thaliana oleate desaturase (FAD2) and the Lesquerella fendleri hydroxylase/desaturase (LFAH) was shown to influence partitioning between desaturation and hydroxylation (Broun, P., Shanklin, J., Whittle, E., and Somerville, C. (1998) Science 282, 1315-1317) [5].
  • C. (1998) Proc. Natl. Acad. Sci. U [6].
 

Biological context of 3-diethylaminopropyl 3-methyl-2-phenyl-pentanoate

  • Using an O-glycosylation-sensitive MUC2 antiserum, a dimerization has been shown to occur in the endoplasmic reticulum of LS 174T cells (Asker, N., Axelsson, M. A. B., Olofsson, S.-O., and Hansson, G. C. (1998) J. Biol. Chem. 273, 18857-18863) [7].
  • Our calculations suggest that the broader specificity of the parasite enzyme is due to a significantly more flexible base-binding region, and rationalize the effect of two mutations, R155E and D163N, that alter substrate specificity [Munagala, N. R., and Wang, C. C. (1998) Biochemistry 37 (47), 16612-16619 (4)] [8].
  • These labeling conditions do not interfere with high-affinity ATP binding, phosphoenzyme formation, or phosphoenzyme hydrolysis [Huang, S., Negash, S., and Squier, T. C. (1998) Biochemistry 37, 6949-6957] [9].
  • Also based on the structure, Phe300 has been reported to be hydroxylated due to a naturally occurring posttranslational modification [Goodwill, K. E., Sabatier, C., and Stevens, R. C. (1998) Biochemistry 37, 13437-13445] [10].
 

Associations of 3-diethylaminopropyl 3-methyl-2-phenyl-pentanoate with other chemical compounds

  • This process, via the lipid products of PI3K, which are potent inhibitors of glucose-6-phosphatase (Mithieux, G., Danièle, N., Payrastre, B., and Zitoun, C. (1998) J. Biol. Chem. 273, 17-19), may account for the inhibition of the enzyme and participate to the inhibition of hepatic glucose production occurring in this situation [11].
 

Gene context of 3-diethylaminopropyl 3-methyl-2-phenyl-pentanoate

  • We have recently shown that insulin-like growth factor (IGF)-binding protein 5 forms ternary complexes with IGF-I or IGF-II and the acid-labile subunit (ALS) (Twigg, S. M., and Baxter, R. C. (1998) J. Biol. Chem. 273, 6074-6079) [12].
  • Endothelial nitric-oxide synthase (type III) (eNOS) was reported to form an inhibitory complex with the bradykinin receptor B2 (B2R) from which the enzyme is released in an active form upon receptor activation (Ju, H., Venema, V. J., Marrero, M. B., and Venema, R. C. (1998) J. Biol. Chem. 273, 24025-24029) [13].
  • We have previously shown that sperm-specific expression of transgenic germinal ACE in Ace -/- male mice restores fertility without curing their other abnormalities (Ramaraj, P., Kessler, S. P., Colmenares, C. & Sen, G. C. (1998) J. Clin. Invest. 102, 371-378) [14].
  • The enzyme was proposed to function as a selenium delivery protein to selenophosphate synthetase in selenoprotein biosynthesis (Lacourciere, G. M., and Stadtman, T. C. (1998) J. Biol. Chem. 273, 30921-30926) [15].
  • Investigation of interactions between hydrophobic model peptides and lipid bilayers is perhaps the only way to elucidate the principles of the folding and stability of membrane proteins (White, S. H., and Wimley, W. C. (1998) Biochim. Biophys. Acta 1367, 339-352) [16].

References

  1. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Bressanelli, S., Tomei, L., Roussel, A., Incitti, I., Vitale, R.L., Mathieu, M., De Francesco, R., Rey, F.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Sex-lethal, the master sex-determining gene in Drosophila, is not sex-specifically regulated in Musca domestica. Meise, M., Hilfiker-Kleiner, D., Dübendorfer, A., Brunner, C., Nöthiger, R., Bopp, D. Development (1998) [Pubmed]
  3. The cellular mechanism by which the dermomyotome contributes to the second wave of myotome development. Kahane, N., Cinnamon, Y., Kalcheim, C. Development (1998) [Pubmed]
  4. Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation. Goo, Y.H., Na, S.Y., Zhang, H., Xu, J., Hong, S., Cheong, J., Lee, S.K., Lee, J.W. J. Biol. Chem. (2004) [Pubmed]
  5. Desaturation and hydroxylation. Residues 148 and 324 of Arabidopsis FAD2, in addition to substrate chain length, exert a major influence in partitioning of catalytic specificity. Broadwater, J.A., Whittle, E., Shanklin, J. J. Biol. Chem. (2002) [Pubmed]
  6. Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine. Zhou, J., Gupta, K., Yao, J., Ye, K., Panda, D., Giannakakou, P., Joshi, H.C. J. Biol. Chem. (2002) [Pubmed]
  7. O-glycosylated MUC2 monomer and dimer from LS 174T cells are water-soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds. Axelsson, M.A., Asker, N., Hansson, G.C. J. Biol. Chem. (1998) [Pubmed]
  8. Understanding substrate specificity in human and parasite phosphoribosyltransferases through calculation and experiment. Pitera, J.W., Munagala, N.R., Wang, C.C., Kollman, P.A. Biochemistry (1999) [Pubmed]
  9. Enhanced rotational dynamics of the phosphorylation domain of the Ca-ATPase upon calcium activation. Huang, S., Squier, T.C. Biochemistry (1998) [Pubmed]
  10. Phenylalanine residues in the active site of tyrosine hydroxylase: mutagenesis of Phe300 and Phe309 to alanine and metal ion-catalyzed hydroxylation of Phe300. Ellis, H.R., Daubner, S.C., McCulloch, R.I., Fitzpatrick, P.F. Biochemistry (1999) [Pubmed]
  11. Phosphatidylinositol 3-kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding. Daniele, N., Rajas, F., Payrastre, B., Mauco, G., Zitoun, C., Mithieux, G. J. Biol. Chem. (1999) [Pubmed]
  12. Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain. Twigg, S.M., Kiefer, M.C., Zapf, J., Baxter, R.C. J. Biol. Chem. (1998) [Pubmed]
  13. Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation. Golser, R., Gorren, A.C., Leber, A., Andrew, P., Habisch, H.J., Werner, E.R., Schmidt, K., Venema, R.C., Mayer, B. J. Biol. Chem. (2000) [Pubmed]
  14. Physiological non-equivalence of the two isoforms of angiotensin-converting enzyme. Kessler, S.P., Rowe, T.M., Gomos, J.B., Kessler, P.M., Sen, G.C. J. Biol. Chem. (2000) [Pubmed]
  15. cDNA cloning, purification, and characterization of mouse liver selenocysteine lyase. Candidate for selenium delivery protein in selenoprotein synthesis. Mihara, H., Kurihara, T., Watanabe, T., Yoshimura, T., Esaki, N. J. Biol. Chem. (2000) [Pubmed]
  16. Topological stability and self-association of a completely hydrophobic model transmembrane helix in lipid bilayers. Yano, Y., Takemoto, T., Kobayashi, S., Yasui, H., Sakurai, H., Ohashi, W., Niwa, M., Futaki, S., Sugiura, Y., Matsuzaki, K. Biochemistry (2002) [Pubmed]
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