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Chemical Compound Review:

Diclonia 1-(4-butoxyphenyl)-3-(1- piperidyl)propan-1...

Synonyms: Dyclonin, Diclonina, Tanaclone, dyclonine, Dyclocaine, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of dyclonine

Therefore, combined treatment with lidocaine and salbutamol can be recommended for awake intubation while the use of dyclonine, despite its excellent and longer lasting topical anesthesia, may be contraindicated in patients with bronchial hyperreactivity [1].
Both patients mistakenly believed that the eruption was expanding herpes simplex labialis, which resulted in their more frequent application of the dyclonine hydrochloride and a delay in diagnosis [2].
Dermatologists should recognize that 1% dyclonine hydrochloride gel can cause allergic contact dermatitis that can masquerade as widespread herpes simplex labialis [2].

Psychiatry related information on dyclonine

In this study we investigated mucosal application of dyclonine on urge to defecate and pain threshold in volunteers and IBS patients (n = 10) [3].

High impact information on dyclonine

CONCLUSION: In asthmatics, awake fiberoptic intubation evokes a more than 50% decrease in FEV1 following dyclonine inhalation [1].
Furthermore, in contrast to saline and lidocaine, inhalation of both ropivacaine and dyclonine significantly decreased forced expiratory volume in 1 s from baseline (P = 0.0016 and 0.0018, respectively) [4].
In contrast, dyclonine, despite its longer lasting and more intense local anesthesia, does not alter histamine-evoked bronchoconstriction and irritates the airways [4].
RESULTS: 5% EMLA cream significantly reduced the pain threshold level followed by 1% dyclonine and 10% benzocaine [5].
Anesthetization of the oropharyngeal membranes and suppression of the gag reflex was accomplished primarily by gargling with dyclonine (1%) and dyclonine (.5%) administered through this adapted atomizer [6].

Chemical compound and disease context of dyclonine

METHODS: In 15 volunteers with bronchial hyperreactivity, a methacholine challenge was performed following the inhalation of lidocaine, dyclonine (which does not attenuate bronchial reactivity) or saline on three different days in a randomized, double-blind fashion [7].

Associations of dyclonine with other chemical compounds

The longest lasting and most intense anesthesia developed after dyclonine inhalation (48 +/- 13 vs. 28 +/- 8 [lidocaine] and 25 +/- 4 min [ropivacaine]) [4].
Nonprescription drug screening. Dyclonine hydrochloride [8].

References

Both local anesthetics and salbutamol pretreatment affect reflex bronchoconstriction in volunteers with asthma undergoing awake fiberoptic intubation. Groeben, H., Schlicht, M., Stieglitz, S., Pavlakovic, G., Peters, J. Anesthesiology (2002) [Pubmed]
Allergic contact dermatitis to dyclonine hydrochloride simulating extensive herpes simplex labialis. Purcell, S.M., Dixon, S.L. J. Am. Acad. Dermatol. (1985) [Pubmed]
Irritable bowel syndrome: a study to investigate the mechanism(s) of visceral hypersensitivity. Greenwood, B., Rodriguez, S., Decktor, D., Maton, P.N., Robinson, M. The Journal of the Oklahoma State Medical Association. (1996) [Pubmed]
Airway anesthesia alone does not explain attenuation of histamine-induced bronchospasm by local anesthetics: a comparison of lidocaine, ropivacaine, and dyclonine. Groeben, H., Grosswendt, T., Silvanus, M.T., Pavlakovic, G., Peters, J. Anesthesiology (2001) [Pubmed]
Evaluating the efficacy of commonly used topical anesthetics. Roghani, S., Duperon, D.F., Barcohana, N. Pediatric dentistry. (1999) [Pubmed]
Adaptation of the de Vilbiss atomizer for the delivery of topical anesthesia. Clark, G.D., Pond, C. Nurse anesthesia. (1992) [Pubmed]
Lidocaine exerts its effect on induced bronchospasm by mitigating reflexes, rather than by attenuation of smooth muscle contraction. Groeben, H., Peters, J. Acta anaesthesiologica Scandinavica (2007) [Pubmed]
Nonprescription drug screening. Dyclonine hydrochloride. Nelson, L.A. American pharmacy. (1987) [Pubmed]

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