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Chemical Compound Review:

Cridanimod 2-(9-oxoacridin-10-yl)ethanoic acid

Synonyms: Cycloferon, Cyclopheron, TPC-I167, AG-A-06460, AG-H-11428, ...

Storch, E. et al., Zarubaev, V.V. et al., Storch, E. et al., Taylor, J.L. et al., Storch, E. et al., et al.

Zarubaev, Slita, Krivitskaya, Sirotkin, Kovalenko, Chatterjee,

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Disease relevance of Cridanimod

A low-molecular-weight chemical inducer of interferon, 10-carboxymethyl-9-acridanone (CMA), effectively prevented death caused by Japanese encephalitis virus (JEV) injected peripherally into weanling mice and baby hamsters [1].
Direct antiviral effect of cycloferon (10-carboxymethyl-9-acridanone) against adenovirus type 6 in vitro [2].
Mice were given single intraperitoneal (i.p.) injections of Corynebacterium parvum, followed, after different time intervals, by i.p. injections of the interferon inducers polyinosinic-polycytidylic acid (poly-I:poly-C), 10-carboxymethyl-9-acridanone (CMA) or herpes simplex virus [3].
Besides the established T-cell property of producing gamma interferon (IFN-gamma), murine T cells additionally possess the ability to produce IFN-alpha and IFN-beta when appropriate inducers such as 10-carboxymethyl-9-acridanone (CMA) or Newcastle disease virus (NDV) are used [4].

High impact information on Cridanimod

Induction of interferon in murine bone marrow-derived macrophage cultures by 10-carboxymethyl-9-acridanone [5].
10-Carboxymethyl-9-acridanone (CMA) induced high titers of interferon (IFN) in murine leukocyte cultures [5].
10-Carboxymethyl-9-acridanone (CMA) was shown to be a very potent interferon inducer in young and old Swiss albino as well as congenitally asplenic mice [6].
Induction of macrophages with the synthetic inducer 10-carboxymethyl-9-acridanone resulted in small amounts of IFN alpha 2, alpha 4, and alpha 6 mRNAs and the IFN beta mRNA level was about 100-fold higher [7].
Non-steroidal anti-inflammatory drugs such as carprofen or indomethacin enhanced interferon (IFN) production induced by suboptimal concentrations of 10-carboxymethyl-9-acridanone (CMA) in murine cell cultures [8].

Anatomical context of Cridanimod

Production of interferon-beta by murine T-cell lines induced by 10-carboxymethyl-9-acridanone [4].

Associations of Cridanimod with other chemical compounds

9-oxo-10-acridineacetic acid bearing the common name of 10-carboxymethyl-9-acridanone or CMA (6) was found to be a very potent interferon (IFN) inducer in adult Balb/c mice [9].
Cyclic AMP metabolism and interferon induction in mice after treatment with 10-carboxymethyl-9-acridanone [10].

Gene context of Cridanimod

We demonstrated direct (non IFN-mediated) antiviral activity of cycloferon (10-carboxymethyl-9-acridanone, CMA), a potent interferon inducer, against adenovirus type 6 (Ad6) in Hep-2 cells [2].

References

Protection against Japanese encephalitis virus in mice and hamsters by treatment with carboxymethylacridanone, a potent interferon inducer. Taylor, J.L., Schoenherr, C., Grossberg, S.E. J. Infect. Dis. (1980) [Pubmed]
Direct antiviral effect of cycloferon (10-carboxymethyl-9-acridanone) against adenovirus type 6 in vitro. Zarubaev, V.V., Slita, A.V., Krivitskaya, V.Z., Sirotkin, A.K., Kovalenko, A.L., Chatterjee, N.K. Antiviral Res. (2003) [Pubmed]
Interferon inducibility in mice treated with Corynebacterium parvum. Storch, E., Kirchner, H. Antiviral Res. (1985) [Pubmed]
Production of interferon-beta by murine T-cell lines induced by 10-carboxymethyl-9-acridanone. Storch, E., Kirchner, H., Brehm, G., Hüller, K., Marcucci, F. Scand. J. Immunol. (1986) [Pubmed]
Induction of interferon in murine bone marrow-derived macrophage cultures by 10-carboxymethyl-9-acridanone. Storch, E., Kirchner, H. Eur. J. Immunol. (1982) [Pubmed]
High-yield interferon induction by 10-carboxymethyl-9-acridanone in mice and hamsters. Taylor, J.L., Schoenherr, C.K., Grossberg, S.E. Antimicrob. Agents Chemother. (1980) [Pubmed]
Cell type specific expression and regulation of murine interferon alpha and beta genes. Hoss-Homfeld, A., Zwarthoff, E.C., Zawatzky, R. Virology (1989) [Pubmed]
Enhancement by carprofen or indomethacin of interferon induction by 10-carboxymethyl-9-acridanone in murine cell cultures. Storch, E., Kirchner, H., Hüller, K., Martinotti, M.G., Gemsa, D. J. Gen. Virol. (1986) [Pubmed]
Induction of interferon in mice by sodium salt of 9-oxo-10-acridineacetic acid: specific enhancement by analogs. Inglot, A.D., Młochowski, J., Szulc, Z., Inglot, O., Albin, M. Arch. Immunol. Ther. Exp. (Warsz.) (1985) [Pubmed]
Cyclic AMP metabolism and interferon induction in mice after treatment with 10-carboxymethyl-9-acridanone. Römer, W., Tonew, E., Schulze, W. Acta Virol. (1986) [Pubmed]

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