Gene Review:
Ifnb1 - interferon beta 1, fibroblast
Mus musculus
Synonyms:
IFN-beta, IFNB, Ifb, Ifnb, Interferon beta
Mizel,
Honko,
Moors,
Smith,
West,
Dikopoulos,
Bertoletti,
Kröger,
Hauser,
Schirmbeck,
Reimann,
Freudenberg,
Merlin,
Kalis,
Chvatchko,
Stübig,
Galanos,
Utaisincharoen,
Anuntagool,
Arjcharoen,
Limposuwan,
Chaisuriya,
Sirisinha,
- RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Takayanagi, H., Kim, S., Matsuo, K., Suzuki, H., Suzuki, T., Sato, K., Yokochi, T., Oda, H., Nakamura, K., Ida, N., Wagner, E.F., Taniguchi, T. Nature (2002)
- Interferon beta, a cofactor in the interferon gamma production induced by gram-negative bacteria in mice. Yaegashi, Y., Nielsen, P., Sing, A., Galanos, C., Freudenberg, M.A. J. Exp. Med. (1995)
- In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors. Duguay, D., Mercier, F., Stagg, J., Martineau, D., Bramson, J., Servant, M., Lin, R., Galipeau, J., Hiscott, J. Cancer Res. (2002)
- IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis. Teige, I., Treschow, A., Teige, A., Mattsson, R., Navikas, V., Leanderson, T., Holmdahl, R., Issazadeh-Navikas, S. J. Immunol. (2003)
- Human interferon-alpha induces immobility in the mouse forced swimming test: involvement of the opioid system. Makino, M., Kitano, Y., Komiyama, C., Hirohashi, M., Kohno, M., Moriyama, M., Takasuna, K. Brain Res. (2000)
- Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., Taniguchi, T. Cell (1988)
- Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Roman, M., Martin-Orozco, E., Goodman, J.S., Nguyen, M.D., Sato, Y., Ronaghy, A., Kornbluth, R.S., Richman, D.D., Carson, D.A., Raz, E. Nat. Med. (1997)
- Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1. Fujita, T., Kimura, Y., Miyamoto, M., Barsoumian, E.L., Taniguchi, T. Nature (1989)
- Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity. Ronco, L.V., Karpova, A.Y., Vidal, M., Howley, P.M. Genes Dev. (1998)
- Binding of Legionella pneumophila to macrophages increases cellular cytokine mRNA. Yamamoto, Y., Okubo, S., Klein, T.W., Onozaki, K., Saito, T., Friedman, H. Infect. Immun. (1994)
- Production of interferon-beta by murine T-cell lines induced by 10-carboxymethyl-9-acridanone. Storch, E., Kirchner, H., Brehm, G., Hüller, K., Marcucci, F. Scand. J. Immunol. (1986)
- TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Toshchakov, V., Jones, B.W., Perera, P.Y., Thomas, K., Cody, M.J., Zhang, S., Williams, B.R., Major, J., Hamilton, T.A., Fenton, M.J., Vogel, S.N. Nat. Immunol. (2002)
- Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids. Wieland, S.F., Eustaquio, A., Whitten-Bauer, C., Boyd, B., Chisari, F.V. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection. Austin, B.A., James, C., Silverman, R.H., Carr, D.J. J. Immunol. (2005)
- The high mobility group protein HMG I(Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms. Du, W., Maniatis, T. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages. Schilling, D., Thomas, K., Nixdorff, K., Vogel, S.N., Fenton, M.J. J. Immunol. (2002)
- TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. Jung, D.Y., Lee, H., Jung, B.Y., Ock, J., Lee, M.S., Lee, W.H., Suk, K. J. Immunol. (2005)
- Species-specific regulation of Toll-like receptor 3 genes in men and mice. Heinz, S., Haehnel, V., Karaghiosoff, M., Schwarzfischer, L., Müller, M., Krause, S.W., Rehli, M. J. Biol. Chem. (2003)
- Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Karaghiosoff, M., Steinborn, R., Kovarik, P., Kriegshäuser, G., Baccarini, M., Donabauer, B., Reichart, U., Kolbe, T., Bogdan, C., Leanderson, T., Levy, D., Decker, T., Müller, M. Nat. Immunol. (2003)
- Type I IFN negatively regulates CD8+ T cell responses through IL-10-producing CD4+ T regulatory 1 cells. Dikopoulos, N., Bertoletti, A., Kröger, A., Hauser, H., Schirmbeck, R., Reimann, J. J. Immunol. (2005)
- Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production. Handa, K., Suzuki, R., Matsui, H., Shimizu, Y., Kumagai, K. J. Immunol. (1983)
- IFN-gamma and IFN-beta independently stimulate the expression of lipopolysaccharide-inducible genes in murine peritoneal macrophages. Hamilton, T.A., Bredon, N., Ohmori, Y., Tannenbaum, C.S. J. Immunol. (1989)
- Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. Ding, A.H., Nathan, C.F., Stuehr, D.J. J. Immunol. (1988)
- Inhibitory activity of constitutive nitric oxide on the expression of alpha/beta interferon genes in murine peritoneal macrophages. Guillemard, E., Varano, B., Belardelli, F., Quero, A.M., Gessani, S. J. Virol. (1999)
- TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression. Park, C., Lee, S., Cho, I.H., Lee, H.K., Kim, D., Choi, S.Y., Oh, S.B., Park, K., Kim, J.S., Lee, S.J. Glia (2006)
- Regulation of interferon responses in medulloblastoma cells by interferon regulatory factor-1 and -2. Park, K.C., Shimizu, K., Hayakawa, T., Tanaka, N. Br. J. Cancer (1998)
- Transcription factor YY1 binds to the murine beta interferon promoter and regulates its transcriptional capacity with a dual activator/repressor role. Weill, L., Shestakova, E., Bonnefoy, E. J. Virol. (2003)
- Induction of iNOS expression and antimicrobial activity by interferon (IFN)-beta is distinct from IFN-gamma in Burkholderia pseudomallei-infected mouse macrophages. Utaisincharoen, P., Anuntagool, N., Arjcharoen, S., Limposuwan, K., Chaisuriya, P., Sirisinha, S. Clin. Exp. Immunol. (2004)
- Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells. Nakamura, K., Deyama, Y., Yoshimura, Y., Suzuki, K., Morita, M. Int. J. Mol. Med. (2007)
- Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. Gamero, A.M., Potla, R., Wegrzyn, J., Szelag, M., Edling, A.E., Shimoda, K., Link, D.C., Dulak, J., Baker, D.P., Tanabe, Y., Grayson, J.M., Larner, A.C. J. Biol. Chem. (2006)
- Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling. Freudenberg, M.A., Merlin, T., Kalis, C., Chvatchko, Y., Stübig, H., Galanos, C. J. Immunol. (2002)
- Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. Mizel, S.B., Honko, A.N., Moors, M.A., Smith, P.S., West, A.P. J. Immunol. (2003)
- Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. Gingras, S., Parganas, E., de Pauw, A., Ihle, J.N., Murray, P.J. J. Biol. Chem. (2004)
- Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide production by the cytokine-inducible pathway. Ma, Y., Seiler, K.P., Tai, K.F., Yang, L., Woods, M., Weis, J.J. Infect. Immun. (1994)
- Mx1 and IP-10: Biomarkers to Measure IFN-beta Activity in Mice Following Gene-Based Delivery. Petry, H., Cashion, L., Szymanski, P., Ast, O., Orme, A., Gross, C., Bauzon, M., Brooks, A., Schaefer, C., Gibson, H., Qian, H., Rubanyi, G.M., Harkins, R.N. J. Interferon Cytokine Res. (2006)
- Exogenous interferon-gamma induces endogenous synthesis of interferon-alpha and -beta by murine macrophages for induction of nitric oxide synthase. Zhou, A., Chen, Z., Rummage, J.A., Jiang, H., Kolosov, M., Kolosova, I., Stewart, C.A., Leu, R.W. J. Interferon Cytokine Res. (1995)