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MeSH Review

Sphincter of Oddi

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Disease relevance of Sphincter of Oddi


Psychiatry related information on Sphincter of Oddi


High impact information on Sphincter of Oddi


Chemical compound and disease context of Sphincter of Oddi


Biological context of Sphincter of Oddi


Anatomical context of Sphincter of Oddi


Associations of Sphincter of Oddi with chemical compounds


Gene context of Sphincter of Oddi

  • CCK and caerulein (as previously found), and also bombesin, OP-CCK and gastrin increased the spikes activity of the sphincter of Oddi [25].
  • NPY at the 500 ng/kg/min dose significantly increased sphincter of Oddi phasic wave frequency, amplitude, and motility index (MI = F X A) [26].
  • The "abnormal" response to cholecystokinin found in group C indicates a motor dysfunction of the sphincter of Oddi, which may have been responsible for, or at least contributed to, the formation of recurrent bile duct stones in this group [27].
  • All of five patients with early cancer are still alive, whereas five with semi-advanced cancer invading the sphincter of Oddi but not the pancreatic parenchyma, and two with a PCNA-positive rate of over 40% died of recurrent cancer [28].
  • Glucagon at high doses of 500 and 1000 ng/kg . min depressed sphincter of Oddi and gastrointestinal spike burst activity, whereas lower doses of glucagon and secretin (3-12 CU/kg . h) had no effect [23].

Analytical, diagnostic and therapeutic context of Sphincter of Oddi


  1. Octreotide-induced pancreatitis: an effect of increased contractility of Oddi sphincter. Bodemar, G., Hjortswang, H. Lancet (1996) [Pubmed]
  2. Ceruletide analgesia in biliary colic. Pardo, A., Celotti, F., De Paolis, C. Clin. Pharmacol. Ther. (1984) [Pubmed]
  3. Biliary dyskinesia: role of the sphincter of Oddi, gallbladder and cholecystokinin. Krishnamurthy, S., Krishnamurthy, G.T. J. Nucl. Med. (1997) [Pubmed]
  4. Nifedipine for suspected type II sphincter of Oddi dyskinesia. Sand, J., Nordback, I., Koskinen, M., Matikainen, M., Lindholm, T.S. Am. J. Gastroenterol. (1993) [Pubmed]
  5. Motility of the sphincter of Oddi and pancreatic main ductal pressure in patients with alcoholic, gallstone-associated, and idiopathic chronic pancreatitis. Okazaki, K., Yamamoto, Y., Nishimori, I., Nishioka, T., Kagiyama, S., Tamura, S., Sakamoto, Y., Nakazawa, Y., Morita, M., Yamamoto, Y. Am. J. Gastroenterol. (1988) [Pubmed]
  6. Neural control of the sphincter of Oddi. A physiological role of 5-hydroxytryptamine in the regulation of basal sphincter of Oddi motor activity in the cat. Behar, J., Biancani, P. J. Clin. Invest. (1983) [Pubmed]
  7. Inhibition of sphincter of Oddi function by the nitric oxide carrier S-nitroso-N-acetylcysteine in rabbits and humans. Slivka, A., Chuttani, R., Carr-Locke, D.L., Kobzik, L., Bredt, D.S., Loscalzo, J., Stamler, J.S. J. Clin. Invest. (1994) [Pubmed]
  8. Vasoactive intestinal polypeptide mediates cholecystokinin-induced relaxation of the sphincter of Oddi. Wiley, J.W., O'Dorisio, T.M., Owyang, C. J. Clin. Invest. (1988) [Pubmed]
  9. Projections of nerve cells from the duodenum to the sphincter of Oddi and gallbladder of the Australian possum. Padbury, R.T., Furness, J.B., Baker, R.A., Toouli, J., Messenger, J.P. Gastroenterology (1993) [Pubmed]
  10. The arginine/nitric oxide pathway modulates sphincter of Oddi motor activity in guinea pigs and rabbits. Mourelle, M., Guarner, F., Moncada, S., Malagelada, J.R. Gastroenterology (1993) [Pubmed]
  11. Nitric oxide inhibits resting sphincter of Oddi activity. Kaufman, H.S., Shermak, M.A., May, C.A., Pitt, H.A., Lillemoe, K.D. Am. J. Surg. (1993) [Pubmed]
  12. Effect of glyceryl trinitrate on the sphincter of Oddi spasm evoked by prostigmine-morphine administration. Velosy, B., Madácsy, L., Lonovics, J., Csernay, L. European journal of gastroenterology & hepatology. (1997) [Pubmed]
  13. Ethanol inhibits sphincter of Oddi motility. Tierney, S., Qian, Z., Lipsett, P.A., Pitt, H.A., Lillemoe, K.D. J. Gastrointest. Surg. (1998) [Pubmed]
  14. Estrogen inhibits sphincter of Oddi motility. Tierney, S., Qian, Z., Burrow, C., Lipsett, P.A., Pitt, H.A., Lillemoe, K.D. J. Surg. Res. (1994) [Pubmed]
  15. Effects of gabexate mesilate, a protease inhibitor, on human sphincter of Oddi motility. Di Francesco, V., Mariani, A., Angelini, G., Masci, E., Frulloni, L., Talamini, G., Passaretti, S., Testoni, P., Cavallini, G. Dig. Dis. Sci. (2002) [Pubmed]
  16. Effect of analgesic drugs on the electromyographic activity of the gastrointestinal tract and sphincter of Oddi and on biliary pressure. Coelho, J.C., Senninger, N., Runkel, N., Herfarth, C., Messmer, K. Ann. Surg. (1986) [Pubmed]
  17. Cholecystokinin-stimulated intracellular signal transduction pathways. Louie, D.S. J. Nutr. (1994) [Pubmed]
  18. Pharmacologic characterization of excitatory and inhibitory cholecystokinin receptors of the cat gallbladder and sphincter of Oddi. Behar, J., Biancani, P. Gastroenterology (1987) [Pubmed]
  19. Endoscopic removal of common bile duct stones through the intact papilla after medical sphincter dilation. Staritz, M., Poralla, T., Dormeyer, H.H., Meyer zum Büschenfelde, K.H. Gastroenterology (1985) [Pubmed]
  20. Naloxone reverses pattern of obstruction of the distal common bile duct induced by analgesic narcotics in hepatobiliary imaging. Patch, G.G., Morton, K.A., Arias, J.M., Datz, F.L. J. Nucl. Med. (1991) [Pubmed]
  21. The effect of ethanol on the pancreatic duct sphincter of Oddi. Goff, J.S. Am. J. Gastroenterol. (1993) [Pubmed]
  22. Nitroglycerine dilatation of sphincter of Oddi for endoscopic removal of bileduct stones. Staritz, M., Poralla, T., Dormeyer, H.H., Ewe, K., Meyer zum Büschenfelde, K.H. Lancet (1984) [Pubmed]
  23. Effect of enteric hormones on sphincter of Oddi and gastrointestinal myoelectric activity in fasted conscious opossums. Honda, R., Toouli, J., Dodds, W.J., Geenen, J.E., Hogan, W.J., Itoh, Z. Gastroenterology (1983) [Pubmed]
  24. Neural control of the sphincter of Oddi. Physiologic role of enkephalins on the regulation of basal sphincter of Oddi motor activity in the cat. Behar, J., Biancani, P. Gastroenterology (1984) [Pubmed]
  25. Action of gastrointestinal hormones on the myoelectric activity of the sphincter of Oddi in living rabbit. Sarles, J.C., Delecourt, P., Castello, H., Gaeta, L., Nacchiero, M., Amoros, J.P., Devaux, M.A., Awad, R. Regul. Pept. (1981) [Pubmed]
  26. Neuropeptide Y: a candidate neurotransmitter for biliary motility. Lillemoe, K.D., Webb, T.H., Pitt, H.A. J. Surg. Res. (1988) [Pubmed]
  27. Bile duct pressure, hormonal influence and recurrent bile duct stones. Linder, S., von Rosen, A., Wiechel, K.L. Hepatogastroenterology (1993) [Pubmed]
  28. The significance of proliferating cell nuclear antigen (PCNA) expression in cancer of the ampulla of vater in terms of prognosis. Isozaki, H., Okajima, K., Ichinona, T., Tanimura, M., Morita, S., Takada, Y., Ishibashi, T., Hara, H. Surgery today. (1994) [Pubmed]
  29. Effects of ethanol on the sphincter of Oddi: an endoscopic manometric study. Viceconte, G. Gut (1983) [Pubmed]
  30. Review article: the relative effectiveness of somatostatin and octreotide therapy in pancreatic disease. Jenkins, S.A., Berein, A. Aliment. Pharmacol. Ther. (1995) [Pubmed]
  31. The pathophysiology, evaluation and management of motility disorders of the biliary tract. Summers, R.W., Johlin, F.C. Gastroenterol. Clin. North Am. (1989) [Pubmed]
  32. The use of intravenous nitroglycerin in a case of spasm of the sphincter of Oddi during laparoscopic cholecystectomy. Toyoyama, H., Kariya, N., Hase, I., Toyoda, Y. Anesthesiology (2001) [Pubmed]
  33. Exocrine hyperstimulation but not pancreatic duct obstruction increases the susceptibility to alcohol-related pancreatic injury. Foitzik, T., Lewandrowski, K.B., Fernández-del Castillo, C., Rattner, D.W., Klar, E., Warshaw, A.L. Archives of surgery (Chicago, Ill. : 1960) (1994) [Pubmed]
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