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MeSH Review


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Disease relevance of Ephedra


High impact information on Ephedra


Chemical compound and disease context of Ephedra


Biological context of Ephedra


Anatomical context of Ephedra


Associations of Ephedra with chemical compounds


Gene context of Ephedra

  • We report here on 6 cases of dilated cardiomyopathy associated with ephedra use [20].
  • Pharmacognostical studies of Ephedra plants Part I - The comparative histological studies on Ephedra rhizomes from Pakistan and Afghanistan and Chinese crude drugs "Ma-Hung-Gen" [21].
  • Analysis with an objective causality assessment scale revealed a probable adverse drug reaction between the patient's use of anabolic steroids, ephedra, and gamma-hydroxybutyrate and the development of his cardiomyopathy and acute liver injury [3].
  • 5.8 S rRNA from the gymnosperm Ephedra kokanica Regl [22].

Analytical, diagnostic and therapeutic context of Ephedra


  1. Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis. Shekelle, P.G., Hardy, M.L., Morton, S.C., Maglione, M., Mojica, W.A., Suttorp, M.J., Rhodes, S.L., Jungvig, L., Gagné, J. JAMA (2003) [Pubmed]
  2. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Boozer, C.N., Daly, P.A., Homel, P., Solomon, J.L., Blanchard, D., Nasser, J.A., Strauss, R., Meredith, T. Int. J. Obes. Relat. Metab. Disord. (2002) [Pubmed]
  3. Dilated cardiomyopathy and acute liver injury associated with combined use of ephedra, gamma-hydroxybutyrate, and anabolic steroids. Clark, B.M., Schofield, R.S. Pharmacotherapy (2005) [Pubmed]
  4. Hypersensitivity myocarditis associated with ephedra use. Zaacks, S.M., Klein, L., Tan, C.D., Rodriguez, E.R., Leikin, J.B. J. Toxicol. Clin. Toxicol. (1999) [Pubmed]
  5. JAMA patient page. Ephedra and ephedrine. Torpy, J.M., Lynm, C., Glass, R.M. JAMA (2003) [Pubmed]
  6. Use of nonprescription weight loss products: results from a multistate survey. Blanck, H.M., Khan, L.K., Serdula, M.K. JAMA (2001) [Pubmed]
  7. Safety and efficacy of citrus aurantium for weight loss. Bent, S., Padula, A., Neuhaus, J. Am. J. Cardiol. (2004) [Pubmed]
  8. Anti-arthritic effects of Ephedra sinica STAPF herb-acupuncture: inhibition of lipopolysaccharide-induced inflammation and adjuvant-induced polyarthritis. Yeom, M.J., Lee, H.C., Kim, G.H., Lee, H.J., Shim, I., Oh, S.K., Kang, S.K., Hahm, D.H. J. Pharmacol. Sci. (2006) [Pubmed]
  9. Effect of a dietary herbal supplement containing caffeine and ephedra on weight, metabolic rate, and body composition. Greenway, F.L., De Jonge, L., Blanchard, D., Frisard, M., Smith, S.R. Obes. Res. (2004) [Pubmed]
  10. Ephedrine pharmacokinetics after the ingestion of nutritional supplements containing Ephedra sinica (ma huang). Gurley, B.J., Gardner, S.F., White, L.M., Wang, P.L. Therapeutic drug monitoring. (1998) [Pubmed]
  11. l-Ephedrine is a major constituent of Mao-Bushi-Saishin-To, one of the formulas of Chinese medicine, which shows immediate inhibition after oral administration of passive cutaneous anaphylaxis in rats. Shibata, H., Nabe, T., Yamamura, H., Kohno, S. Inflamm. Res. (2000) [Pubmed]
  12. Caffeine-herbal ephedra combination increases resting energy expenditure, heart rate and blood pressure. Vukovich, M.D., Schoorman, R., Heilman, C., Jacob, P., Benowitz, N.L. Clin. Exp. Pharmacol. Physiol. (2005) [Pubmed]
  13. Nitrosation products from the plant Ephedra altissima and their potential endogenous formation. Tricker, A.R., Wacker, C.D., Preussmann, R. Cancer Lett. (1987) [Pubmed]
  14. Seizure activity and unresponsiveness after hydroxycut ingestion. Kockler, D.R., McCarthy, M.W., Lawson, C.L. Pharmacotherapy (2001) [Pubmed]
  15. Mechanisms of neurotransmitter release by amphetamines: a review. Sulzer, D., Sonders, M.S., Poulsen, N.W., Galli, A. Prog. Neurobiol. (2005) [Pubmed]
  16. Dietary supplements for body-weight reduction: a systematic review. Pittler, M.H., Ernst, E. Am. J. Clin. Nutr. (2004) [Pubmed]
  17. Antioxidant-independent ascorbate enhancement of catecholamine-induced contractions of vascular smooth muscle. Dillon, P.F., Root-Bernstein, R.S., Lieder, C.M. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  18. Pharmacological actions of analogues of feruloylhistamine, an imidazole alkaloid of Ephedra roots. Hikino, H., Kiso, Y., Ogata, M., Konno, C., Aisaka, K., Kubota, H., Hirose, N., Ishihara, T. Planta Med. (1984) [Pubmed]
  19. Hypotensive actions of ephedradines, macrocyclic spermine alkaloids of Ephedra roots. Hikino, H., Ogata, K., Konno, C., Sato, S. Planta Med. (1983) [Pubmed]
  20. Is there an association between ephedra and heart failure? a case series. Peters, C.M., O'Neill, J.O., Young, J.B., Bott-Silverman, C. J. Card. Fail. (2005) [Pubmed]
  21. Pharmacognostical studies of Ephedra plants Part I - The comparative histological studies on Ephedra rhizomes from Pakistan and Afghanistan and Chinese crude drugs "Ma-Hung-Gen". Namba, T., Kubo, M., Kanai, Y., Namba, K., Nishimura, H., Qazilbash, N.A. Planta Med. (1976) [Pubmed]
  22. Comparative analysis of 5.8 S rRNA from Ephedra kokanica Regl. (Gymnospermae) and other plant species. Melekhovets YuF, n.u.l.l., Troitsky, A.V. Biochim. Biophys. Acta (1990) [Pubmed]
  23. Ephedrine-type alkaloid content of nutritional supplements containing Ephedra sinica (Ma-huang) as determined by high performance liquid chromatography. Gurley, B.J., Wang, P., Gardner, S.F. Journal of pharmaceutical sciences. (1998) [Pubmed]
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