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Chemical Compound Review

AC1L972T     (2R,3R,4S,5S)-2- [(2R,3S,4R,5R)-4,5,6...

Synonyms:
 
 
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Disease relevance of Panose

 

High impact information on Panose

  • Inhibition tests with various sugars show that the combining site of myeloma protein CAL20 TEPC1035 is most complementary to panose, a trisaccharide DGlc alpha(1 leads to 6)DGlc alpha(1 leads to 4)DGlc [5].
  • However, it could also attack and degrade pullulan and beta-cyclodextrin, which are resistant to alpha-amylase, to primarily produce panose and maltoheptaose, respectively [6].
  • In this study, we continuously monitored, second-by-second, concentration changes of two different carbohydrates (maltose and panose) by using monoclonal antibodies in an optical immunosensor based on total internal reflection fluorescence [7].
  • In earlier studies we have demonstrated that the three monoclonal antibodies 39.4 (IgG2b), 39.5 (IgG2b) and 61.1(IgG3) bind weakly to the glycosidic alpha(1-4) bond present in e.g. maltose and panose [8].
  • It rapidly converted maltose to panose (Glc alpha-->6 Glc alpha l-->4 Glc) with a Vmax value of 5.8 mmol l-1 min-1 at 50 degrees C in 0.05 mol l-1 sodium acetate buffer (pH 4.4) [9].
 

Biological context of Panose

  • The substrate specificity on pullulan and panose, specific activity, optimum pH, pH stability, and susceptibility to certain chemical reagents were similar between IPU F1 and IPU F2 [10].
 

Associations of Panose with other chemical compounds

  • The caries inhibitory activity of GOS-sugar (panose- and maltose-rich sugar mixture) was examined and compared with that of sucrose, maltose, or glucose in in vitro and in vivo experiments [11].
  • Insoluble, light-sensitive polymers linked to maltose, maltotriose, a glycogen-branch point trisaccharide, and panose were synthesized and served in a comparative study as acceptors in the glycogen synthase (UDP-D-glucose:glycogen 4-alpha-D-glucosyltransferase, EC 2.4.1.11) reaction [12].

References

  1. Three-dimensional structure and substrate binding of Bacillus stearothermophilus neopullulanase. Hondoh, H., Kuriki, T., Matsuura, Y. J. Mol. Biol. (2003) [Pubmed]
  2. The crystal structure of Thermoactinomyces vulgaris R-47 alpha-amylase II (TVA II) complexed with transglycosylated product. Mizuno, M., Tonozuka, T., Uechi, A., Ohtaki, A., Ichikawa, K., Kamitori, S., Nishikawa, A., Sakano, Y. Eur. J. Biochem. (2004) [Pubmed]
  3. Effects of panose on glucan synthesis and cellular adherence by Streptococcus mutans. Koga, T., Horikoshi, T., Fujiwara, T., Hamada, S. Microbiol. Immunol. (1988) [Pubmed]
  4. Control of the synthesis of dextran and acceptor-products by Leuconostoc mesenteroides B-512FM dextransucrase. Su, D., Robyt, J.F. Carbohydr. Res. (1993) [Pubmed]
  5. Immunochemical specificity of the combining site of murine myeloma protein CAL20 TEPC1035 reactive with dextrans. Sugii, S., Kabat, E.A., Shapiro, M., Potter, M. J. Exp. Med. (1981) [Pubmed]
  6. Enzymatic analysis of an amylolytic enzyme from the hyperthermophilic archaeon Pyrococcus furiosus reveals its novel catalytic properties as both an alpha-amylase and a cyclodextrin-hydrolyzing enzyme. Yang, S.J., Lee, H.S., Park, C.S., Kim, Y.R., Moon, T.W., Park, K.H. Appl. Environ. Microbiol. (2004) [Pubmed]
  7. A label-free continuous total-internal-reflection-fluorescence-based immunosensor. Engström, H.A., Andersson, P.O., Ohlson, S. Anal. Biochem. (2006) [Pubmed]
  8. Analysis of the specificity and thermodynamics of the interaction between low affinity antibodies and carbohydrate antigens using fluorescence spectroscopy. Engström, H.A., Andersson, P.O., Ohlson, S. J. Immunol. Methods (2005) [Pubmed]
  9. Glucosyltransferase activity of commercial juice-processing enzyme preparations. Hang, Y.D., Woodams, E.E. Lett. Appl. Microbiol. (1997) [Pubmed]
  10. Two components of cell-bound isopullulanase from Aspergillus niger ATCC 9642--their purification and enzymatic properties. Aoki, H., Yopi, n.u.l.l., Padmajanti, A., Sakano, Y. Biosci. Biotechnol. Biochem. (1996) [Pubmed]
  11. The caries inhibitory effects of GOS-sugar in vitro and in rat experiments. Ooshima, T., Fujiwara, T., Takei, T., Izumitani, A., Sobue, S., Hamada, S. Microbiol. Immunol. (1988) [Pubmed]
  12. Polymers having (1----4)- and (1----6)-linked alpha-D-glucopyranosyl groups as acceptors in the glycogen synthase reaction. Zehavi, U., Herchman, M., Köpper, S. Carbohydr. Res. (1992) [Pubmed]
 
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