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Disease relevance of Micromonosporaceae


High impact information on Micromonosporaceae


Chemical compound and disease context of Micromonosporaceae

  • Fully active enzymes with chymotrypsic activity were demonstrated in moldy hay samples where Micropolyspora faeni was found as the predominant saprophyte by using polyacrylamide gel electrophoresis [11].
  • The isolation and the characterization of one of the enzymes of Micropolyspora faeni that hydrolyzes the substrate N-benzoyl-DL-phenylalanine-beta-naphthyl ester and that seems to be of medical importance are described [12].
  • The chemotaxonomic data, except for the lack of arabinose in the whole-cell sugars, indicate that this strain belongs to the family Micromonosporaceae [13].
  • The purification, characterization, cloning and sequencing of the gene for a halostable and thermostable leucine dehydrogenase from Thermoactinomyces intermedius [14].
  • Alphan alpha-amylase (TVA II) from Thermoactinomyces vulgaris R-47 efficiently hydrolyzes alpha-1,4-glucosidic linkages of pullulan to produce panose in addition to hydrolyzing starch [15].

Biological context of Micromonosporaceae


Anatomical context of Micromonosporaceae


Gene context of Micromonosporaceae

  • To characterize interactions that occur in vitro that result in cells able to transfer EHP, we added either antibody to IFN-gamma, antibody to IL-2, or 30 or 300 micrograms/ml IFN-gamma at the onset of 72-hour culture of C3H/HeJ spleen cells from either M. faeni or ovalbumin (control) sensitized donors with 30 micrograms/ml Micropolyspora faeni [23].
  • Verrucosispora gifhornensis gen. nov., sp. nov., a new member of the actinobacterial family Micromonosporaceae [24].
  • As found previously with other Bacillus species, spores of B. stearothermophilus and "Thermoactinomyces thalpophilus" contained significant levels of small, acid-soluble spore proteins (SASP) which were rapidly degraded during spore germination and which reacted with antibodies raised against B. megaterium SASP [25].
  • Potent immunogenicity of certain extracellular 'chymotrypsin-like' enzymes of Micropolyspora faeni are demonstrated [26].
  • Specificity of a neutral Zn-dependent proteinase from Thermoactinomyces sacchari toward the oxidized insulin B chain [27].

Analytical, diagnostic and therapeutic context of Micromonosporaceae


  1. Malate dehydrogenases from actinomycetes: structural comparison of Thermoactinomyces enzyme with other actinomycete and Bacillus enzymes. Smith, K., Sundaram, T.K., Kernick, M. J. Bacteriol. (1984) [Pubmed]
  2. Circulating immune complexes and rheumatoid factors in patients with farmer's lung. Terho, E.O., Lindström, P., Mäntyjärvi, R., Tukiainen, H., Wager, O. Allergy (1983) [Pubmed]
  3. Effects of allergen challenge on plasma concentrations of prostaglandins, thromboxane B2, and histamine in calves infected with bovine respiratory syncytial virus. Gershwin, L.J., Giri, S.N. Am. J. Vet. Res. (1992) [Pubmed]
  4. Effect of inhalation of organic dust-derived microbial agents on the pulmonary phagocytic oxidative metabolism of guinea pigs. Milanowski, J. J. Toxicol. Environ. Health Part A (1998) [Pubmed]
  5. Granulomatous lung disease by Thermoactinomyces vulgaris antigen in C5 deficient and sufficient mice. Nogami, M., Takizawa, H., Ohta, K., Suko, M., Okudaira, H., Itoh, K., Miyamoto, T., Shiga, J. J. Exp. Pathol. (1987) [Pubmed]
  6. Complex structures of Thermoactinomyces vulgaris R-47 alpha-amylase 2 with acarbose and cyclodextrins demonstrate the multiple substrate recognition mechanism. Ohtaki, A., Mizuno, M., Tonozuka, T., Sakano, Y., Kamitori, S. J. Biol. Chem. (2004) [Pubmed]
  7. The locus of tumor necrosis factor-alpha action in lung inflammation. Smith, S., Skerrett, S.J., Chi, E.Y., Jonas, M., Mohler, K., Wilson, C.B. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
  8. A serine proteinase of an archaebacterium, Halobacterium mediterranei. A homologue of eubacterial subtilisins. Stepanov, V.M., Rudenskaya, G.N., Revina, L.P., Gryaznova, Y.B., Lysogorskaya, E.N., Filippova IYu, n.u.l.l., Ivanova, I.I. Biochem. J. (1992) [Pubmed]
  9. Characterization of allergen extracts by two-dimensional electrophoretic techniques: Micropolyspora faeni antigens. Vesterberg, O., Holmberg, K. Clin. Chem. (1982) [Pubmed]
  10. Crossed immunoelectrophoretic analysis of two antigen extracts of Thermoactinomyces candidus. Hollick, G.E., Larsh, H.W. Infect. Immun. (1979) [Pubmed]
  11. Extracellular enzymes of Micropolyspora faeni found in moldy hay. Nicolet, J., Bannerman, E.N. Infect. Immun. (1975) [Pubmed]
  12. Isolation and characterization of an enzyme with esterase activity from Micropolyspora faeni. Bannerman, E.N., Nicolet, J. Appl. Environ. Microbiol. (1976) [Pubmed]
  13. A new genus of the order Actinomycetales, Spirilliplanes gen. nov., with description of Spirilliplanes yamanashiensis sp. nov. Tamura, T., Hayakawa, M., Hatano, K. Int. J. Syst. Bacteriol. (1997) [Pubmed]
  14. The purification, characterization, cloning and sequencing of the gene for a halostable and thermostable leucine dehydrogenase from Thermoactinomyces intermedius. Ohshima, T., Nishida, N., Bakthavatsalam, S., Kataoka, K., Takada, H., Yoshimura, T., Esaki, N., Soda, K. Eur. J. Biochem. (1994) [Pubmed]
  15. The crystal structure of Thermoactinomyces vulgaris R-47 alpha-amylase II (TVA II) complexed with transglycosylated product. Mizuno, M., Tonozuka, T., Uechi, A., Ohtaki, A., Ichikawa, K., Kamitori, S., Nishikawa, A., Sakano, Y. Eur. J. Biochem. (2004) [Pubmed]
  16. Proposal of the genus Thermoactinomyces sensu stricto and three new genera, Laceyella, Thermoflavimicrobium and Seinonella, on the basis of phenotypic, phylogenetic and chemotaxonomic analyses. Yoon, J.H., Kim, I.G., Shin, Y.K., Park, Y.H. Int. J. Syst. Evol. Microbiol. (2005) [Pubmed]
  17. Purification and properties of the highly thermostable alkaline protease from an alkaliphilic and thermophilic Bacillus sp. Fujiwara, N., Masui, A., Imanaka, T. J. Biotechnol. (1993) [Pubmed]
  18. Thermostable phenylalanine dehydrogenase of Thermoactinomyces intermedius: cloning, expression, and sequencing of its gene. Takada, H., Yoshimura, T., Ohshima, T., Esaki, N., Soda, K. J. Biochem. (1991) [Pubmed]
  19. Identification of active site lysyl residues of phenylalanine dehydrogenase by chemical modification with methyl acetyl phosphate combined with site-directed mutagenesis. Kataoka, K., Tanizawa, K., Fukui, T., Ueno, H., Yoshimura, T., Esaki, N., Soda, K. J. Biochem. (1994) [Pubmed]
  20. Investigations on the substrate specificity of thermitase, a thermostable serine-protease from Thermoactinomyces vulgaris. Rothe, U., Brömme, D., Könnecke, A., Kleine, R. Acta Biol. Med. Ger. (1982) [Pubmed]
  21. Macrophage responses to mouldy hay dust, Micropolyspora faeni and zymosan, activators of complement by the alternative pathway. Schorlemmer, H.U., Edwards, J.H., Davies, P., Allison, A.C. Clin. Exp. Immunol. (1977) [Pubmed]
  22. Ca2+ dependence and inhibitory effects of trifluoperazine on plasma membrane ATPase of Thermoactinomyces vulgaris. Bhatnagar, K., Singh, V.P. Curr. Microbiol. (2004) [Pubmed]
  23. Experimental hypersensitivity pneumonitis: in vitro effects of interleukin-2 and interferon-gamma. Fei, R., Gott, K., Edwards, B., Schuyler, M. J. Lab. Clin. Med. (1995) [Pubmed]
  24. Verrucosispora gifhornensis gen. nov., sp. nov., a new member of the actinobacterial family Micromonosporaceae. Rheims, H., Schumann, P., Rohde, M., Stackebrandt, E. Int. J. Syst. Bacteriol. (1998) [Pubmed]
  25. Cloning and nucleotide sequencing of genes for small, acid-soluble spore proteins of Bacillus cereus, Bacillus stearothermophilus, and "Thermoactinomyces thalpophilus". Loshon, C.A., Fliss, E.R., Setlow, B., Foerster, H.F., Setlow, P. J. Bacteriol. (1986) [Pubmed]
  26. Farmer's lung: immunological response to a group of extracellular enzymes of Micropolyspora faeni. An experimental and field study. Nicolet, J., Bannerman, E.N., De Haller, R., Wanner, M. Clin. Exp. Immunol. (1977) [Pubmed]
  27. Specificity of a neutral Zn-dependent proteinase from Thermoactinomyces sacchari toward the oxidized insulin B chain. Georgieva, D.N., Stoeva, S., Ivanova, V., Gusterova, A., Voelter, W. Curr. Microbiol. (2000) [Pubmed]
  28. Crystallization and preliminary X-ray analysis of substrate complexes of leucine dehydrogenase from Thermoactinomyces intermedius. Muranova, T.A., Ruzheinikov, S.N., Sedelnikova, S.E., Baker, P.J., Pasquo, A., Galkin, A., Esaki, N., Ohshima, T., Soda, K., Rice, D.W. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
  29. Site-directed mutagenesis of a hexapeptide segment involved in substrate recognition of phenylalanine dehydrogenase from Thermoactinomyces intermedius. Kataoka, K., Takada, H., Yoshimura, T., Furuyoshi, S., Esaki, N., Ohshima, T., Soda, K. J. Biochem. (1993) [Pubmed]
  30. Antibody responses in patients with farmer's lung disease to antigens from Thermoactinomyces vulgaris. Hollingdale, M.R. The Journal of hygiene. (1975) [Pubmed]
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