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Chemical Compound Review

QYIMSPSDBYKPPY-LJAQVGFWSA-N     (3S)-2,2-dimethyl-3- (3,7,12,16,20...

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High impact information on C01054


Biological context of C01054

  • The ability of some azasqualene derivatives to inhibit yeast cell growth was compared with their inhibition activity on squalene-2,3-oxide cyclase (EC both in living cells and in microsome preparations [6].

Anatomical context of C01054


  1. Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. Shibata, N., Arita, M., Misaki, Y., Dohmae, N., Takio, K., Ono, T., Inoue, K., Arai, H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae. Shi, Z., Buntel, C.J., Griffin, J.H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Topographic heterogeneity in cholesterol biosynthesis. Lange, Y., Muraski, M.F. J. Biol. Chem. (1988) [Pubmed]
  4. Effects of a supernatant protein activator on microsomal squalene-2,3-oxide-lanosterol cyclase. Caras, I.W., Bloch, K. J. Biol. Chem. (1979) [Pubmed]
  5. Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA contents in human hepatoma cell line Hep G2 by distinct classes of mevalonate-derived metabolites. Cohen, L.H., Griffioen, M. Biochem. J. (1988) [Pubmed]
  6. Inhibition of sterol biosynthesis in Saccharomyces cerevisiae by N,N-diethylazasqualene and derivatives. Balliano, G., Viola, F., Ceruti, M., Cattel, L. Biochim. Biophys. Acta (1988) [Pubmed]
  7. An alternative mechanism for the inhibition of cholesterol biosynthesis in HepG2 cells by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol (MDL 28,815). Van Sickle, W.A., Wilson, P.K., Wannamaker, M.W., Cooper, J.R., Flanagan, M.A., McCarthy, J.R., Bey, P., Jackson, R.L. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
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