Chemical Compound Review:
AG-F-00121 2-(2-diethylaminoethoxy)- 10,13-dimethyl-1...
Synonyms:
AC1L2BLI, CTK8G3682, LS-186692
This record was replaced with 18225.
- The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. Neufeld, E.B., Stonik, J.A., Demosky, S.J., Knapper, C.L., Combs, C.A., Cooney, A., Comly, M., Dwyer, N., Blanchette-Mackie, J., Remaley, A.T., Santamarina-Fojo, S., Brewer, H.B. J. Biol. Chem. (2004)
- Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor. Cenedella, R.J., Jacob, R., Borchman, D., Tang, D., Neely, A.R., Samadi, A., Mason, R.P., Sexton, P. J. Lipid Res. (2004)
- DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis. Di Stasi, D., Vallacchi, V., Campi, V., Ranzani, T., Daniotti, M., Chiodini, E., Fiorentini, S., Greeve, I., Prinetti, A., Rivoltini, L., Pierotti, M.A., Rodolfo, M. Int. J. Cancer (2005)
- Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. Jeng, I., Klemm, N., Samson, L. Biochem. Pharmacol. (1985)
- Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: Bridging Niemann-Pick disease type C and Alzheimer's disease. Koh, C.H., Cheung, N.S. Cell. Signal. (2006)
- Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease. Patel, S.C., Suresh, S., Kumar, U., Hu, C.Y., Cooney, A., Blanchette-Mackie, E.J., Neufeld, E.B., Patel, R.C., Brady, R.O., Patel, Y.C., Pentchev, P.G., Ong, W.Y. Proc. Natl. Acad. Sci. U.S.A. (1999)
- The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein. Harada, M., Kawaguchi, T., Kumemura, H., Terada, K., Ninomiya, H., Taniguchi, E., Hanada, S., Baba, S., Maeyama, M., Koga, H., Ueno, T., Furuta, K., Suganuma, T., Sugiyama, T., Sata, M. Am. J. Pathol. (2005)
- Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)). Kametaka, S., Shibata, M., Moroe, K., Kanamori, S., Ohsawa, Y., Waguri, S., Sims, P.J., Emoto, K., Umeda, M., Uchiyama, Y. J. Biol. Chem. (2003)
- Unsaturated fatty acid-mediated decreases in sterol regulatory element-mediated gene transcription are linked to cellular sphingolipid metabolism. Worgall, T.S., Johnson, R.A., Seo, T., Gierens, H., Deckelbaum, R.J. J. Biol. Chem. (2002)
- Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes. Mani, K., Cheng, F., Fransson, L.A. Glycobiology (2006)
- Source of cholesterol for the ocular lens, studied with U18666A: a cataract-producing inhibitor of lipid metabolism. Cenedella, R.J. Exp. Eye Res. (1983)
- Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons. Cheung, N.S., Koh, C.H., Bay, B.H., Qi, R.Z., Choy, M.S., Li, Q.T., Wong, K.P., Whiteman, M. Biochem. Biophys. Res. Commun. (2004)
- The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one. Liscum, L., Faust, J.R. J. Biol. Chem. (1989)
- Characterization of Chinese hamster ovary cells that are resistant to 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one inhibition of low density lipoprotein-derived cholesterol metabolism. Liscum, L., Collins, G.J. J. Biol. Chem. (1991)
- Neuronal apoptosis mediated by inhibition of intracellular cholesterol transport: Microarray and proteomics analyses in cultured murine cortical neurons. Koh, C.H., Peng, Z.F., Ou, K., Melendez, A., Manikandan, J., Qi, R.Z., Cheung, N.S. J. Cell. Physiol. (2007)
- Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons. Koh, C.H., Whiteman, M., Li, Q.X., Halliwell, B., Jenner, A.M., Wong, B.S., Laughton, K.M., Wenk, M., Masters, C.L., Beart, P.M., Bernard, O., Cheung, N.S. J. Neurochem. (2006)
- ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity. Feng, B., Tabas, I. J. Biol. Chem. (2002)
- Cholesterol modulates the membrane binding and intracellular distribution of annexin 6. de Diego, I., Schwartz, F., Siegfried, H., Dauterstedt, P., Heeren, J., Beisiegel, U., Enrich, C., Grewal, T. J. Biol. Chem. (2002)
- The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells. Kobayashi, T., Vischer, U.M., Rosnoblet, C., Lebrand, C., Lindsay, M., Parton, R.G., Kruithof, E.K., Gruenberg, J. Mol. Biol. Cell (2000)
- Pharmacological sequestration of intracellular cholesterol in late endosomes disrupts ruffled border formation in osteoclasts. Zhao, H., Väänänen, H.K. J. Bone Miner. Res. (2006)
- Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol. Warner, G.J., Stoudt, G., Bamberger, M., Johnson, W.J., Rothblat, G.H. J. Biol. Chem. (1995)
- Interrelationships of ubiquinone and sterol syntheses in cultured cells of neural origin. Volpe, J.J., Obert, K.A. J. Neurochem. (1982)
- Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols. Panini, S.R., Sexton, R.C., Gupta, A.K., Parish, E.J., Chitrakorn, S., Rudney, H. J. Lipid Res. (1986)
- Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions. Bae, S., Seong, J., Paik, Y. Biochem. J. (2001)
- Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells. Davis, W., Boyd, J.T., Ile, K.E., Tew, K.D. Biochim. Biophys. Acta (2004)
- Differential effects of sphingomyelin hydrolysis and cholesterol transport on oxysterol-binding protein phosphorylation and Golgi localization. Ridgway, N.D., Lagace, T.A., Cook, H.W., Byers, D.M. J. Biol. Chem. (1998)
- Accumulation of tyrosinase in the endolysosomal compartment is induced by U18666A. Hall, A.M., Krishnamoorthy, L., Orlow, S.J. Pigment Cell Res. (2003)
- Formation of multivesicular endosomes in Dictyostelium. Marchetti, A., Mercanti, V., Cornillon, S., Alibaud, L., Charette, S.J., Cosson, P. J. Cell. Sci. (2004)
- Abnormal benzodiazepine and zinc modulation of GABAA receptors in an acquired absence epilepsy model. Wu, J., Ellsworth, K., Ellsworth, M., Schroeder, K.M., Smith, K., Fisher, R.S. Brain Res. (2004)
- Calcium activated proteolysis and protein modification in the U18666A cataract. Chandrasekher, G., Cenedella, R.J. Exp. Eye Res. (1993)