Disease relevance of L 3428

• It was concluded that while the experimental form would be of interest, the risk of severe hypotension after i.v. Cordarone can be largely avoided by using a slower rate of infusion, especially in patients with hypovolemic status [1].
• However, the standard formulation (Cordarone IV) frequently causes hypotension [2].
• Amiodarone (Cordarone) is an iodinated compound widely used in the treatment of cardiac arrhythmias for more than a decade [3].
• Amiodarone (Cordarone) has been proven to be useful in the management of atrial fibrillation [4].
• Electrophysiologic studies were performed in nine patients with reentrant paroxysmal supraventricular tachycardia (PSVT) during a control period and following 5 mg/kg body weight of intravenous amiodarone (Cordarone, Labaz) administered as a slow continuous infusion over 15 to 20 minutes [5].

High impact information on L 3428

• This is a significant advantage over the standard amiodarone formulation, because Cordarone cannot be administered by rapid bolus owing to excipient-related hypotension [6].
• Amiodarone hydrochloride (Cordarone) is an effective antiarrhythmic drug which can cause a potentially fatal pneumonitis [7].
• BACKGROUND: Amiodarone (Cordarone; Wyeth, Ayerst, New York) is a potassium channel blocking antiarrythmal medication indicated for recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia [8].
• The study on arterial blood pressure showed that Cordarone caused a significant decrease in blood pressure at each of the 3, 5, 10, and 20 mg/kg doses (P < 0.05 to P < 0.001) while Amio-Aqueous did not [9].
• The acute toxicology study showed that both LD50 and LD100 were 30% greater for Amio-Aqueous than for Cordarone [9].

Chemical compound and disease context of L 3428

• In conclusion, Cordarone IV was more toxic and caused significant hypotension and negative inotropy while Amio-Aqueous lacked the hypotensive and cardiotoxic properties of Cordarone [9].
• The concentrations of amiodarone (Cordarone) and desethylamiodarone in plasma after single oral and intravenous and long-term oral dosing were determined in seven normal subjects and 106 patients with various cardiac arrhythmias, respectively, using a high-performance liquid chromatographic method [10].

Biological context of L 3428

• We guess that this effect of Cordarone is caused by its influence on the heart rate, which is slowing down, by its antiarrhythmic effect and by its efficiency to improve the perfusion of myocardium by its power to decrease the resistance of coronary vessels [11].

Anatomical context of L 3428

• The effect of cordarone on isoproterenol-induced damage to the myocardium in rats [11].

References