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Chemical Compound Review

Canaline     (2S)-2-amino-4-aminooxy- butanoic acid

Synonyms: L-Canaline, AG-F-66393, CHEMBL1231652, CHEBI:41401, HMDB12251, ...
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Disease relevance of C08270


High impact information on C08270


Chemical compound and disease context of C08270

  • The capacity of these compounds to overcome the cytotoxic effects of L-canavanine or L-canaline was assessed in order to provide insight into the biochemical mechanisms that may underlie the toxicity of these two novel anticancer agents [6].

Anatomical context of C08270


Gene context of C08270


  1. A mechanism of L-canaline toxicity. Rosenthal, G.A. Eur. J. Biochem. (1981) [Pubmed]
  2. Physiological cyclic stretch directs L-arginine transport and metabolism to collagen synthesis in vascular smooth muscle. Durante, W., Liao, L., Reyna, S.V., Peyton, K.J., Schafer, A.I. FASEB J. (2000) [Pubmed]
  3. Interaction of L-canaline with ornithine aminotransferase of the tobacco hornworm, Manduca sexta (Sphingidae). Rosenthal, G.A., Dahlman, D.L. J. Biol. Chem. (1990) [Pubmed]
  4. Glutamate in the inferior colliculus plays a critical role in audiogenic seizure initiation. Faingold, C.L., Naritoku, D.K., Copley, C.A., Randall, M.E., Riaz, A., Anderson, C.A., Arnerić, S.P. Epilepsy Res. (1992) [Pubmed]
  5. Electrical stimulation-evoked release of endogenous aspartate from rat medulla oblongata slices. Effects of inhibitors of aspartate aminotransferase and GABA transaminase. Kubo, T., Kihara, M., Misu, Y. Naunyn Schmiedebergs Arch. Pharmacol. (1990) [Pubmed]
  6. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Bence, A.K., Worthen, D.R., Adams, V.R., Crooks, P.A. Anticancer Drugs (2002) [Pubmed]
  7. Accumulation of ornithine by chick retinal pigment epithelium cells in culture. Baich, A., Nekola, M. Biochim. Biophys. Acta (1988) [Pubmed]
  8. Ornithine as a precursor of neurotransmitter glutamate: effect of canaline on ornithine aminotransferase activity and glutamate content in the septum of rat brain. Wroblewski, J.T., Blaker, W.D., Meek, J.L. Brain Res. (1985) [Pubmed]
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