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Chemical Compound Review

CP-60     2-[(2-methoxy-3- octadecylsulfanyl-propoxy)...

Synonyms: CHEMBL441962, AC1L9QFK
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Disease relevance of 2-[hydroxy-(2-methoxy-3-octadecylthio-propoxy)phosphoryl]oxyethyl-trimethyl-ammonium


High impact information on 2-[hydroxy-(2-methoxy-3-octadecylthio-propoxy)phosphoryl]oxyethyl-trimethyl-ammonium


Anatomical context of 2-[hydroxy-(2-methoxy-3-octadecylthio-propoxy)phosphoryl]oxyethyl-trimethyl-ammonium

  • We describe an attempt to incorporate a metabolically inert phospholipid analog into animal membranes, especially myelin, in vivo, with the view of eventual long-term membrane modification or membrane engineering [8].

Associations of 2-[hydroxy-(2-methoxy-3-octadecylthio-propoxy)phosphoryl]oxyethyl-trimethyl-ammonium with other chemical compounds

  • The fluorescent phospholipid analog N-(lissamine rhodamine B sulfonyl)phosphatidylethanolamine (N-Rh-PE) was inserted into the plasma membrane of Baby hamster kidney cells at low temperature (2 degrees C) [9].
  • A phospholipid analog 1-palmitoyl-2-6(pyren-1-yl)hexanoyl-sn-glycero-3-phospho-N- (trinitrophenyl)aminoethanol (PPHTE) in which pyrene fluorescence is intramolecularly quenched by the trinitrophenyl group was used as a substrate for pancreatic phospholipase A2 [10].
  • Sequence-specific resonance assignments of the peptide have been made in the presence of micelles of a phospholipid analog, perdeuterated dodecylphosphocholine (DPC), with the aid of such techniques as HOHAHA, DQF-COSY, and NOESY [11].

Gene context of 2-[hydroxy-(2-methoxy-3-octadecylthio-propoxy)phosphoryl]oxyethyl-trimethyl-ammonium


Analytical, diagnostic and therapeutic context of 2-[hydroxy-(2-methoxy-3-octadecylthio-propoxy)phosphoryl]oxyethyl-trimethyl-ammonium


  1. Reconstitution and partial characterization of phospholipid flippase activity from detergent extracts of the Bacillus subtilis cell membrane. Hrafnsdóttir, S., Menon, A.K. J. Bacteriol. (2000) [Pubmed]
  2. Effects of miltefosine on membrane permeability and accumulation of [99mTc]-hexakis-2-methoxyisobutyl isonitrile, 2-[18F]fluoro-2-deoxy-D-glucose, daunorubucin and rhodamine123 in multidrug-resistant and sensitive cells. Márián, T., Balkay, L., Trón, L., Krasznai, Z.T., Szabó-Péli, J., Krasznai, Z. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2005) [Pubmed]
  3. Capping of a phospholipid analog in the plasma membrane of lymphocytes. Schroit, A.J., Pagano, R.E. Cell (1981) [Pubmed]
  4. Lateral diffusion in nuclear membranes. Schindler, M., Holland, J.F., Hogan, M. J. Cell Biol. (1985) [Pubmed]
  5. Transient confinement of a glycosylphosphatidylinositol-anchored protein in the plasma membrane. Sheets, E.D., Lee, G.M., Simson, R., Jacobson, K. Biochemistry (1997) [Pubmed]
  6. Interdigitation does not affect translational diffusion of lipids in liquid crystalline bilayers. Schram, V., Thompson, T.E. Biophys. J. (1995) [Pubmed]
  7. Polar head group decarboxylation and methylation of phospholipids: an alternate route for phosphatidylcholine formation in cultured neuronal cells. Yavin, E. J. Neurochem. (1985) [Pubmed]
  8. Retention of a dialkylphosphatidylcholine in myelin and other membranes. Brockerhoff, H., Wisniewski, H.M., Lipton, L.C., Deshmukh, D.S. Neurochem. Res. (1980) [Pubmed]
  9. A non-exchangeable fluorescent phospholipid analog as a membrane traffic marker of the endocytic pathway. Willem, J., ter Beest, M., Scherphof, G., Hoekstra, D. Eur. J. Cell Biol. (1990) [Pubmed]
  10. Phospholipase A2 assay using an intramolecularly quenched pyrene-labeled phospholipid analog as a substrate. Thuren, T., Virtanen, J.A., Somerharju, P.J., Kinnunen, P.K. Anal. Biochem. (1988) [Pubmed]
  11. N-terminal half of a mitochondrial presequence peptide takes a helical conformation when bound to dodecylphosphocholine micelles: a proton nuclear magnetic resonance study. Endo, T., Shimada, I., Roise, D., Inagaki, F. J. Biochem. (1989) [Pubmed]
  12. Very-low-density lipoprotein of uremic patients is a poor substrate for bovine lipoprotein lipase in vitro. Arnadottir, M., Dallongeville, J., Fruchart, J.C., Nilsson-Ehle, P. Metab. Clin. Exp. (1996) [Pubmed]
  13. Characterization of the non-specific lipid transfer protein EP2 from carrot (Daucus carota L.). Meijer, E.A., de Vries, S.C., Sterk, P., Gadella, D.W., Wirtz, K.W., Hendriks, T. Mol. Cell. Biochem. (1993) [Pubmed]
  14. Effect of eicosatetraenyl (3-aminopropyl) phosphonate (URI-73A) on platelet aggregation and arachidonic acid metabolism. Mower, R.L., Landolfi, R., Steiner, M., Welch, D.K., Turcotte, J.G. Prostaglandins, leukotrienes, and medicine. (1983) [Pubmed]
  15. Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels. Possani, L.D., Martin, B.M., Yatani, A., Mochca-Morales, J., Zamudio, F.Z., Gurrola, G.B., Brown, A.M. Toxicon (1992) [Pubmed]
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